scholarly journals Kawasaki disease manifesting as bilateral facial nerve palsy and meningitis: a case report and literature review

2019 ◽  
Vol 47 (8) ◽  
pp. 4014-4018 ◽  
Author(s):  
Bo Zhang ◽  
Yunpeng Hao ◽  
Yanfeng Zhang ◽  
Nuo Yang ◽  
Hang Li ◽  
...  

Background Kawasaki disease (KD) is an acute multisystem vasculitic syndrome that predominantly affects infants and young children. Neurological complications are rare in patients with KD and the diagnosis is challenging. We report a case of KD that manifested as bilateral facial nerve palsy and meningitis. Case report A 6-month-old boy presented with a 10-day history of fever. Four days before admission, the patient developed a rash, conjunctival injection, perioral and perianal excoriation, and bilateral facial nerve palsy. Brain magnetic resonance imaging was normal. Echocardiography showed dilated coronary arteries and coronary artery aneurysms. A cerebrospinal fluid examination showed an elevated leukocyte count. A diagnosis of KD was made, and the patient was treated with gamma globulin and aspirin. The patient’s fever subsided on the following day and the right-sided facial nerve palsy was relieved 1 month later. An 18-month follow-up showed that the left-sided facial nerve palsy persisted and the patient’s condition remained stable. Conclusion KD manifesting as bilateral facial nerve palsy and meningitis is extremely rare. Clinicians should be aware of this condition, and early diagnosis and appropriate treatment should be emphasized.

2019 ◽  
Vol 48 (3) ◽  
pp. 030006051986749
Author(s):  
Yu-Ming Liu ◽  
Yan-Li Chen ◽  
Yan-Hua Deng ◽  
Yan-Ling Liang ◽  
Wei Li ◽  
...  

Miller Fisher syndrome (MFS), a variant of Guillain–Barré syndrome, is characterized by ataxia, areflexia and ophthalmoplegia. This case report describes a 40-year old male that presented with a 3-day history of unsteady walking and numbness on both hands, and a 2-day history of seeing double images and unclear articulation. Lumbar puncture revealed an opening pressure of 260 mm H2O. Plasma serology was positive for anti-ganglioside M1-immunoglobulin M (anti-GM1-IgM) antibodies and negative for anti-ganglioside Q1b (anti-GQ1b) antibodies. The patient was diagnosed with MFS based on the clinical course and neurophysiological findings. On the 4th day of treatment with intravenous immunoglobulin (IVIG), his ataxia and unsteady walking improved, but his bilateral eyeballs were fixed, and over the next few days he developed bilateral peripheral facial paralysis. After 5 days of IVIG treatment, methylprednisolone treatment was offered and the patient's symptoms gradually improved. Early intracranial hypertension and delayed facial nerve palsy may be atypical presentations of MFS. Anti-GM1-IgM antibodies may be the causative antibodies for MFS. If the IVIG therapy does not stop the progression of the disease, the addition of corticosteroid therapy may be effective. However, the relationship between IgM type, anti-GM1 antibody and MFS remains unclear and requires further research.


2003 ◽  
Vol 26 (2) ◽  
pp. 207-209
Author(s):  
G. Aren

Mobius Syndrome is characterized by showing unilateral facial nerve palsy of the sixth and seventh nerves, lack of facial expression, inability to smile and to tightly close the right eyelids. In this report, a 7-year-old-boy with Mobius syndrome is presented. He had asymmetry of facial expression, anomalies of fingers and severe tooth decay. After dental treatment, the periodic re-care visits should be done according to the eruption pattern.


F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1734
Author(s):  
Richard Menzies-Wilson ◽  
Gentle Wong ◽  
Prodip Das

We present a rare case of a four-year-old boy with a botyroid embryonal rhabdomyosarcoma of the right middle ear. Rhabdomyosarcoma is a soft tissue malignancy which is thought to originate from embryonic mesenchymal cells of striated skeletal muscle.  It is a disease primarily of children and is exceptionally rare in parameningeal regions.  The diagnosis is often delayed and easily misdiagnosed as aural polyp. Therefore, advanced disease is common at the time of diagnosis.  A four-year-old boy presented with a four-month history of recurrent left ear blood and pus discharge, otalgia and fevers. He attended his GP three times and paediatric A&E 13 times where he received antibiotics for presumed otitis media and externa. He was eventually referred to the otolaryngology department and underwent an examination under anaesthesia of ear and excisional biopsy of a suspicious aural polyp.  Staging chest CT and PET scan showed no loco-regional spread or distal metastasis. Magnetic resonance imaging demonstrated absence of invasion into adjacent organs.  Histology confirmed embryonal rhabdomyosarcoma, botryoid subtype.  Subsequent to the initial excision of the polyp, he was started on an ifosfamine, vincristine and actinomycin (IVA) chemotherapy regime in three weekly cycles for nine cycles with concomitant radiotherapy. Two weeks subsequent to his first chemotherapy dose he presented with a House-Brackmann II-III facial nerve palsy but no other middle ear complications. He was started on intravenous antibiotics and dexamethasone. The facial nerve palsy incompletely resolved with treatment.


2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Jerome Okudo ◽  
Yemi Oluyide

Melkersson-Rosenthal Syndrome (MRS) is a rare otoneurologic condition, which is poorly understood and often underdiagnosed. Etiology and incidence are unclear, although infectious, inflammatory, and genetic causes have been implicated. Recurrent facial nerve palsy, facial swelling, and fissured tongue are the symptoms and signs of this condition. However, this triad is not typical in all patients as patients may present with one or more of the symptoms, which makes management of this condition difficult. Steroids may prove to be useful especially in patients who have facial nerve palsy. In this case report, we have described a 46 year-old Caucasian male who presented to the clinic for the evaluation of orofacial swelling and left facial deviation with a history of multiple treatments for recurrent lower motor neuron type facial nerve palsy.


2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alejandra Peña-Juárez ◽  
Miguel Angel Medina-Andrade ◽  
Itzel Estefani Ríos Olivares ◽  
José Luis Colín-Ortíz ◽  
Marco Antonio Yamazaki-Nakashimada ◽  
...  

2020 ◽  
Vol 30 (12) ◽  
pp. 1957-1959
Author(s):  
Ye Yuan ◽  
Na Lu

AbstractKawasaki disease is the leading cause of acquired heart disease in infants and young children. Kawasaki disease that manifests as facial nerve palsy is extremely rare, and the diagnosis is challenging. We report a 4-month-old girl with Kawasaki disease who presented with fever, redness and cracking in the lips and oral cavity, and a right facial nerve palsy. The infant received intravenous immunoglobulin, acetyl salicylic acid, and warfarin. The patient’s fever subsided on the following day, and the right-sided facial nerve palsy was relieved a month later.


2021 ◽  
Author(s):  
Julia Loureiro Gaudencio ◽  
Hilton Mariano Mariano da Silva Júnior ◽  
Pedro Neves Fortunato

Context: Ramsay Hunt syndrome is a condition caused by the Varicella-Zoster Virus in the geniculate ganglion and leads to peripheral facial nerve palsy and erythematous vesicular rash in the affected area. It is a rare disorder but is the second most common cause of peripheral facial nerve palsy without trauma. Cerebral venous thrombosis is a rare cerebrovascular disease and responsible for only 0.5% of all strokes. Among its causes are oral contraceptives, infection in the central nervous system, systemic inflammations, and thrombophilia. Case report: We report the case of a previously healthy 29 years old woman diagnosed with Ramsay Hunt syndrome followed by cerebral venous thrombosis two weeks later. Her first admission to the hospital was due to pain in the face and a pulsing type right hemicranial headache. It started in the cervical region and was irradiated to the right retroorbital and auricular area, with difficulty contracting the right eyelid, otalgia, and vertigo. She used oral contraceptives, had two cesarean deliveries, and quitted smoking at 20 years old. She had multidirectional and bilateral nystagmus with fast phase to the left, right peripheral face paralysis, and crusts in the right ear canal. The patient was treated with aciclovir and prednisone, with good recovery. Two weeks later, she returned because of two episodes of convulsion and headache. Brain CTA (computed tomography angiography) showed cerebral venous thrombosis. Conclusion: Cerebral venous thrombosis is a rare complication of Ramsay Hunt Syndrome. It is important to stay alert to the development of vascular complications in these patients.


2010 ◽  
Vol 1 ◽  
pp. IJCM.S4894
Author(s):  
Manpreet Singh Tiwana ◽  
Shrinivas Rathod ◽  
Tejpal Gupta ◽  
Jai Prakash Agarwal

We present the case of a 67-year-old man with a three month history of right sided facial nerve palsy reporting to our clinic for evaluation of a recently seen suspicious mass in the right lung. Subsequently he was diagnosed with advanced NSCLC right lung and started on palliative chemotherapy. Furthermore, temporal bone metastasis was discovered on radiological imaging while investigating symptoms of acute mastoiditis and persisting facial neuralgia, a symptom completely overlooked at first as Idiopathic Bell's palsy. This presentation is exceptionally unique, although temporal bone metastasis arising from established primary lung or other malignancies is itself rare, and predilect to a later onset in the natural history of the disease, as reported in the literature. None of the published literature report neither addresses the optimal management course nor its subsequent impact on quality of life of patients with temporal bone metastasis.


Author(s):  
Narges Karimia ◽  
◽  
Athena Sharifi-Razavi ◽  

New corona virus named as COVID-19 can presented not only by respiratory symptoms, but also with other organs involvement such as gastrointestinal, cardiac, renal and neurological symptoms. We reported a patient who presented with peripheral facial nerve palsy and evaluations revealed COVID-19 infection. We suggest from this case, that COVID-19 infection may be a potential cause of facial paralysis and during this terrible pandemic, neurologists will need to be vigilant for the any neurological manifestation or neurological complications of covid-19.


F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1734
Author(s):  
Richard Menzies-Wilson ◽  
Gentle Wong ◽  
Prodip Das

We present a rare case of a four-year-old boy with a botyroid embryonal rhabdomyosarcoma of the right middle ear. Rhabdomyosarcoma is a soft tissue malignancy which is thought to originate from embryonic mesenchymal cells of striated skeletal muscle.  It is a disease primarily of children and is exceptionally rare in parameningeal regions.  The diagnosis is often delayed and easily misdiagnosed as aural polyp. Therefore, advanced disease is common at the time of diagnosis.  A four-year-old boy presented with a four-month history of recurrent left ear blood and pus discharge, otalgia and fevers. He attended his GP three times and paediatric A&E 13 times where he received antibiotics for presumed otitis media and externa. He was eventually referred to the otolaryngology department and underwent an examination under anaesthesia of ear and excisional biopsy of a suspicious aural polyp.  Staging chest CT and PET scan showed no loco-regional spread or distal metastasis. Magnetic resonance imaging demonstrated absence of invasion into adjacent organs.  Histology confirmed embryonal rhabdomyosarcoma, botryoid subtype.  Subsequent to the initial excision of the polyp, he was started on an ifosfamine, vincristine and actinomycin (IVA) chemotherapy regime in three weekly cycles for nine cycles with concomitant radiotherapy. Two weeks subsequent to his first chemotherapy dose he presented with a House-Brackmann II-III facial nerve palsy but no other middle ear complications. He was started on intravenous antibiotics and dexamethasone. The facial nerve palsy incompletely resolved with treatment.


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