scholarly journals Refractory primary extramedullary plasmacytoma in kidney: a case report

2021 ◽  
Vol 49 (12) ◽  
pp. 030006052110637
Author(s):  
Wenjie Niu ◽  
Lili Zhang ◽  
Yuhai Wu ◽  
Kai Li ◽  
Lixia Sun ◽  
...  

Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm, with the majority (80–90% of cases) occurring in the upper aerodigestive tract. To our best knowledge, primary EMP from renal tissues is extremely rare. Herein, the diagnosis and treatment of a refractory primary EMP with renal involvement in a 53-year-old male patient is reported. The patient received radical nephrectomy followed by radiotherapy, and showed relapse 3 months after treatment. The cancer cells were sensitive to subsequent chemotherapy, however, the patient died of infection associated with the disease after almost 3.5 years following first presentation.

2021 ◽  
Vol 21 ◽  
pp. S437-S438
Author(s):  
Carine Ribeiro Franzon ◽  
Andressa Oliveira Martin Wagner ◽  
Annelise Correa Wengerkievicz Lopes ◽  
Douglas Gebauer Bona ◽  
Talita Bertazzo Schmitz

2021 ◽  
Vol 21 ◽  
pp. S257
Author(s):  
Carine Ribeiro Franzon ◽  
Andressa Oliveira Martin Wagner ◽  
Annelise Correa Wengerkievicz Lopes ◽  
Douglas Gebauer Bona ◽  
Talita Bertazzo Schmitz

2017 ◽  
Vol 9 (1) ◽  
pp. 35
Author(s):  
Isabelle Deli Lestadi ◽  
Nurjati Chaerani Siregar ◽  
Puspita Eka Wuyung

BACKGROUND: Plasma cell neoplasm (PCN) is a neoplastic plasma cell proliferation which includes solitary bone plasmacytoma (SBP), extramedullary plasmacytoma (EMP) and multiple myeloma (MM). Bartl classifies the degrees of PCN as low, intermediate and high. The aim of this study is to find the correlation between tumor suppressor gene p53 (TP53) expression and Ki-67 proliferation with Bartl malignancy degree of PCN. Therefore earlier PCN diagnostic method to prevent the development of PCN into MM can be found.METHODS: Thirty-two PCN cases were classified into three groups based on Bartl’s degrees of malignancy. TP53 and Ki-67 immunohistochemical staining were performed on samples and the percentage of positivity was evaluated.RESULTS: The Bartl’s low degree of malignancy was found in 10 MM cases (31.2%), intermediate degree in  5 SBP cases (15.6%) and high in 2 SBP and EMP cases (6.2%). TP53 expression was obtainable at 4% of low, 16% of intermediate and 10% of high degree. There was a significant difference between TP53 expression in low and intermediate degree (p=0.004). Mean proliferation index of Ki-67 was 57% in low, 44.6% in intermediate, and 32.6% in high degree. There was no significant difference of Ki-67 proliferation indexes among the group (p=0.339).CONCLUSION: Increasing expression TP53 was in accord with Bartl’s degrees of malignancy, especially in low and intermediate degree, but there was no significant difference between Ki-67 proliferation index and Bartl’s degrees of malignancy.KEYWORDS: plasmacytoma, myeloma, TP53, Ki-67, Bartl classification


2012 ◽  
Vol 65 (11) ◽  
pp. 1050-1052 ◽  
Author(s):  
Marco Pizzi ◽  
Elena Sabattini ◽  
Gaia Goteri ◽  
Paolo Pierani ◽  
Francesco Bacci ◽  
...  

Cureus ◽  
2019 ◽  
Author(s):  
Arslan Naeem ◽  
Surabhi Amar ◽  
Divyesh Mehta ◽  
Mustafa N Malik

2012 ◽  
Vol 2 (2) ◽  
pp. 80 ◽  
Author(s):  
Yusun Hwang ◽  
Wha Soon Chung ◽  
Ki-Sook Hong

eJHaem ◽  
2021 ◽  
Author(s):  
Muntadhar Al Moosawi ◽  
Julia L. Varghese ◽  
Hayley Merkeley ◽  
Mohammad Bahmanyar ◽  
Stephen Parkin

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