Carbon ion radiotherapy with complete tumor regression for primary malignant melanoma of female urethra orifice: a case report

Primary malignant melanoma of the female urethra (PMMFU) is extremely rare, accounting for 0.2% of all melanomas, and fewer than 200 cases have been reported worldwide. Because of the small number of clinical cases and unclear biological characteristics, there is no uniform and standard treatment protocol. We herein describe the treatment of PMMFU using carbon ion radiotherapy. The radiotherapy was delivered at 60.8 Gy (RBE) in 16 fractions, once daily, five times per week. The patient achieved complete tumor disappearance within 1 year after carbon ion radiotherapy and remained disease-free thereafter. She developed acute grade 1 radiation dermatitis and urethritis, which resolved quickly; no other toxic effects were observed. At the time of this writing, her survival duration was 33 months. This case demonstrates that carbon ion radiotherapy may be a good option for primary genitourinary mucosal malignancies.

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Carbon ion radiotherapy for recurrent calf myxoid liposarcoma: a case report

Journal of International Medical Research ◽

10.1177/03000605211009701 ◽

2021 ◽

Vol 49 (4) ◽

pp. 030006052110097

Author(s):

Xiaojun Li ◽

Yanshan Zhang ◽

Yancheng Ye ◽

Ying Qi ◽

Chunlan Feng ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcomas ◽

Myxoid Liposarcoma ◽

Ion Beams ◽

Carbon Ion Radiotherapy ◽

Irradiation Damage ◽

Radiation Dermatitis ◽

Complete Disappearance ◽

Carbon Ion ◽

The Right

Liposarcoma (LPS) is the most common soft tissue sarcoma. Myxoid LPS (MLPS) is the second most common subtype of LPS and accounts for 25% to 50% of all LPSs. Like most other soft tissue sarcomas, the mainstay of treatment for LPS is inevitably surgery. Multidisciplinary approaches, including surgery, chemotherapy, and radiotherapy, have been successful in the treatment of LPS during the last three decades. Even so, recurrence of LPS remains challenging. Carbon ion beams produce increased energy deposition at the end of their range to form a Bragg peak while minimizing irradiation damage to surrounding tissues, which facilitates more precise dosage and localization than that achieved with photon beams. Furthermore, carbon ion beams have high relative biologic effectiveness. We herein describe a patient who developed recurrent MLPS in the right calf after two surgeries and underwent carbon ion radiotherapy (CIRT), achieving complete disappearance of the tumor. The patient developed Grade 1 radiation dermatitis 30 days after CIRT, but no other acute toxicities were observed. The tumor had completely disappeared by 120 days after CIRT, and the patient remained disease-free for 27 months after CIRT. The CARE guidelines were followed in the reporting of this case.

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Primary Malignant Melanoma of the Female Urethra: A Case Report with Immunohistochemical Findings

Urologia Internationalis ◽

10.1159/000281317 ◽

1988 ◽

Vol 43 (2) ◽

pp. 110-112 ◽

Cited By ~ 3

Author(s):

G. Barbagli ◽

A. Natali ◽

C. Urso ◽

G. Barbanti ◽

I. Menchi ◽

...

Keyword(s):

Case Report ◽

Malignant Melanoma ◽

Primary Malignant Melanoma ◽

Female Urethra

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Primary malignant melanoma of the female urethra: a rare case of cytological observation

Pathology Discovery ◽

10.7243/2052-7896-2-5 ◽

2014 ◽

Vol 2 (1) ◽

pp. 5 ◽

Cited By ~ 1

Author(s):

Naomi Kawaguchi ◽

Kyoko Nambu ◽

Asuka Sekiya ◽

Toshimasa Sakakima ◽

Masashi Matsuyama ◽

...

Keyword(s):

Malignant Melanoma ◽

Rare Case ◽

Primary Malignant Melanoma ◽

Cytological Observation ◽

Female Urethra

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Primary Malignant Melanoma of the Female Urethra: A Case Report

Japanese Journal of Clinical Oncology ◽

10.1093/oxfordjournals.jjco.a039612 ◽

1993 ◽

Keyword(s):

Case Report ◽

Malignant Melanoma ◽

Primary Malignant Melanoma ◽

Female Urethra

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Primary malignant melanoma of the female urethra: 10-year survival

Medical Oncology ◽

10.1007/s12032-011-0055-1 ◽

2011 ◽

Vol 29 (3) ◽

pp. 2016-2017 ◽

Cited By ~ 3

Author(s):

Silvio Altarac ◽

Dino Papeš

Keyword(s):

Malignant Melanoma ◽

Primary Malignant Melanoma ◽

Female Urethra

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Primary malignant melanoma of the female urethra: Report of a rare neoplasm of the urinary tract

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2017.11.001 ◽

2017 ◽

Vol 41 ◽

pp. 319-322 ◽

Cited By ~ 5

Author(s):

Namita Bhutani ◽

Pradeep Kajal ◽

Devendra Pawar

Keyword(s):

Urinary Tract ◽

Malignant Melanoma ◽

Primary Malignant Melanoma ◽

Female Urethra ◽

Rare Neoplasm

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Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck

Diagnostics ◽

10.3390/diagnostics10020082 ◽

2020 ◽

Vol 10 (2) ◽

pp. 82

Author(s):

Hidenori Suzuki ◽

Eiichi Sasaki ◽

Risa Motai ◽

Seiya Goto ◽

Daisuke Nishikawa ◽

...

Keyword(s):

Malignant Melanoma ◽

Head And Neck ◽

Neck Dissection ◽

Initial Treatment ◽

Concurrent Chemotherapy ◽

Carbon Ion Radiotherapy ◽

Safety And Efficacy ◽

Carbon Ion ◽

Mucosal Malignant Melanoma ◽

Salvage Neck Dissection

Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon–ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.

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