Carbon Ion Radiotherapy for Malignant Melanoma of Female Genital Organs

e16548 Background: Malignant melanoma of the female genital organs is a very rare tumor and resistant to conventional photon radiotherapy. We report six cases of female genital malignant melanoma those were well controlled locally by carbon ion radiotherapy (CIRT). Methods: Between November 2004 and October 2008, six patients with unresectable female genital malignant melanoma were treated with CIRT. Age of the patients ranged from 55 to 80 years (median; 69 years). Four patients had previously untreated locally invasive tumors and other two had locally recurrent tumors after surgery and adjuvant chemotherapy. The tumor located in the vagina (4 patients), both the cervix and the vagina (1 patient), or both the vagina and the vulva (1 patient). Two patients had inguinal lymph node metastasis and two had distant metastases at CIRT. All patients received a total dose of 57.6 gray equivalent (GyE) in 16 fractions over 4 weeks of CIRT. Three patients received chemotherapy using dacarbazine, ACNU, and vincristine after CIRT. Results: The follow-up durations after CIRT were from 9 to 20 months (median; 13 months). No patient developed severe acute toxicity during CIRT. No late toxicity of greater Grade 2 was experienced, while Grade 1 proctitis was observed in a patient. All tumors completely responded to CIRT. No patient developed in-field recurrence. The four patients without distant metastasis were alive with no evidence of disease for 9–20 months after CIRT. The two patients with distant metastases died from metastatic disease 13 and 18 months after CIRT, respectively. Conclusions: CIRT achieved favorable local tumor control without developing severe acute and late toxicity in the treatment of unresectable malignant melanoma of the female genital organs. No significant financial relationships to disclose.

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Carbon ion radiotherapy with complete tumor regression for primary malignant melanoma of female urethra orifice: a case report

Journal of International Medical Research ◽

10.1177/03000605211072795 ◽

2022 ◽

Vol 50 (1) ◽

pp. 030006052110727

Author(s):

Xiaojun Li ◽

Yihe Zhang ◽

Yanshan Zhang ◽

Yancheng Ye ◽

Ying Qi ◽

...

Keyword(s):

Malignant Melanoma ◽

Tumor Regression ◽

Treatment Protocol ◽

Carbon Ion Radiotherapy ◽

Primary Malignant Melanoma ◽

Radiation Dermatitis ◽

Survival Duration ◽

Female Urethra ◽

Carbon Ion ◽

Complete Tumor

Primary malignant melanoma of the female urethra (PMMFU) is extremely rare, accounting for 0.2% of all melanomas, and fewer than 200 cases have been reported worldwide. Because of the small number of clinical cases and unclear biological characteristics, there is no uniform and standard treatment protocol. We herein describe the treatment of PMMFU using carbon ion radiotherapy. The radiotherapy was delivered at 60.8 Gy (RBE) in 16 fractions, once daily, five times per week. The patient achieved complete tumor disappearance within 1 year after carbon ion radiotherapy and remained disease-free thereafter. She developed acute grade 1 radiation dermatitis and urethritis, which resolved quickly; no other toxic effects were observed. At the time of this writing, her survival duration was 33 months. This case demonstrates that carbon ion radiotherapy may be a good option for primary genitourinary mucosal malignancies.

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Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck

Diagnostics ◽

10.3390/diagnostics10020082 ◽

2020 ◽

Vol 10 (2) ◽

pp. 82

Author(s):

Hidenori Suzuki ◽

Eiichi Sasaki ◽

Risa Motai ◽

Seiya Goto ◽

Daisuke Nishikawa ◽

...

Keyword(s):

Malignant Melanoma ◽

Head And Neck ◽

Neck Dissection ◽

Initial Treatment ◽

Concurrent Chemotherapy ◽

Carbon Ion Radiotherapy ◽

Safety And Efficacy ◽

Carbon Ion ◽

Mucosal Malignant Melanoma ◽

Salvage Neck Dissection

Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon–ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.

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Long-term outcomes after carbon ion-radiotherapy for oral mucosal malignant melanoma

Japanese Journal of Oral & Maxillofacial Surgery ◽

10.5794/jjoms.64.237 ◽

2018 ◽

Vol 64 (4) ◽

pp. 237-242

Author(s):

Kensuke NAGANAWA ◽

Masashi KOTO ◽

Ryo TAKAGI ◽

Azusa HASEGAWA ◽

Hiroaki IKAWA ◽

...

Keyword(s):

Malignant Melanoma ◽

Carbon Ion Radiotherapy ◽

Long Term Outcomes ◽

Carbon Ion ◽

Mucosal Malignant Melanoma

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Efficacy and safety of carbon‐ion radiotherapy for the malignant melanoma: A systematic review

Cancer Medicine ◽

10.1002/cam4.3134 ◽

2020 ◽

Vol 9 (15) ◽

pp. 5293-5305

Author(s):

Chengcheng Li ◽

Qiuning Zhang ◽

Zheng Li ◽

Shuangwu Feng ◽

Hongtao Luo ◽

...

Keyword(s):

Systematic Review ◽

Malignant Melanoma ◽

Carbon Ion Radiotherapy ◽

Efficacy And Safety ◽

Carbon Ion

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Histological Study of Choroidal Malignant Melanoma Treated by Carbon Ion Radiotherapy

Japanese Journal of Ophthalmology ◽

10.1007/s10384-006-0404-3 ◽

2007 ◽

Vol 51 (2) ◽

pp. 127-130 ◽

Cited By ~ 2

Author(s):

Masatoshi Tsuji ◽

Katsuaki Kimura ◽

Hiroshi Tsuji ◽

Masamichi Goto ◽

Hiroshi Yoshikawa ◽

...

Keyword(s):

Malignant Melanoma ◽

Histological Study ◽

Carbon Ion Radiotherapy ◽

Carbon Ion ◽

Choroidal Malignant Melanoma

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Mucosal Malignant Melanoma of the Head and Neck Treated by Carbon Ion Radiotherapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2008.07.056 ◽

2009 ◽

Vol 74 (1) ◽

pp. 15-20 ◽

Cited By ~ 90

Author(s):

Takeshi Yanagi ◽

Jun-etsu Mizoe ◽

Azusa Hasegawa ◽

Ryo Takagi ◽

Hiroki Bessho ◽

...

Keyword(s):

Malignant Melanoma ◽

Head And Neck ◽

Carbon Ion Radiotherapy ◽

Carbon Ion ◽

Mucosal Malignant Melanoma

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Carbon Ion Radiotherapy for Mucosal Malignant Melanoma of the Head and Neck

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2005.07.609 ◽

2005 ◽

Vol 63 ◽

pp. S356 ◽

Cited By ~ 3

Author(s):

K. Kagawa ◽

H. Mayahara ◽

Y. Oda ◽

A. Kawaguchi ◽

M. Murakami ◽

...

Keyword(s):

Malignant Melanoma ◽

Head And Neck ◽

Carbon Ion Radiotherapy ◽

Carbon Ion ◽

Mucosal Malignant Melanoma

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Long-term outcomes after carbon-ion radiotherapy for oral mucosal malignant melanoma

Journal of Radiation Research ◽

10.1093/jrr/rrw117 ◽

2016 ◽

Vol 58 (4) ◽

pp. 517-522 ◽

Cited By ~ 8

Author(s):

Kensuke Naganawa ◽

Masashi Koto ◽

Ryo Takagi ◽

Azusa Hasegawa ◽

Hiroaki Ikawa ◽

...

Keyword(s):

Overall Survival ◽

Malignant Melanoma ◽

Local Control ◽

Significant Risk ◽

Carbon Ion Radiotherapy ◽

Significant Prognostic Factor ◽

Effective Treatment Option ◽

Carbon Ion ◽

Mucosal Malignant Melanoma

Abstract Oral mucosal malignant melanoma (OMM) is extremely rare and has a poor prognosis. Owing to its rarity, it has not yet been possible to establish an optimal treatment modality. The objective of this study was to evaluate the long-term efficacy of carbon-ion radiotherapy (C-ion RT) for OMM. Between 1997 and 2013, 19 patients with OMM were treated with C-ion RT alone. Patient ages ranged from 44 to 84 years (median, 69 years). Nine men and 10 women were included. OMMs were restaged in accordance with the seventh edition of the tumour/node/metastasis (TNM) Staging System of the International Union Against Cancer. Before treatment, 14 patients had T3 disease and 5 had T4a disease. Three patients were classified as having N1 disease. All patients were classified as having M0. The hard palate was the most frequently involved oral subsite. All patients were treated with 57.6 Gy (relative biological effectiveness) in 16 fractions. The median follow-up period was 61 months (range, 8–190 months). The 5-year local control, overall survival and progression-free survival rates were 89.5%, 57.4% and 51.6%, respectively. For local control and overall survival, T classification was found to be a significant prognostic factor. Grade 2 and 3 osteoradionecrosis was observed in three and four patients, respectively. The presence of teeth within the planning target volume was a significant risk factor for developing osteoradionecrosis. C-ion RT was an effective treatment option with acceptable toxicity for OMM.

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