Developing Optimum Drug Regimens

1976 ◽  
Vol 4 (5) ◽  
pp. 277-280
Author(s):  
Michael S Carey ◽  
Robert W Noyes ◽  
Samuel A Pasquale ◽  
John J Frey ◽  
John S Lawson

In Clinical pharmacological trials the determination of the optimum regimen for a drug using the technique of response surface analysis is proposed as being more advantageous than traditional analyses of dose response relationships. Major considerations in favour of this technique are that the optimum regimen can be identified with a minimum of human experimentation, and unacceptable regimens are eliminated from the study early, at a substantial saving of time and money.

1988 ◽  
Vol 34 (5) ◽  
pp. 954-957 ◽  
Author(s):  
C Flandrois ◽  
C Lahet ◽  
D Feldmann ◽  
J M Gabastou ◽  
A Gonnon ◽  
...  

Abstract Optimization of determination of alanine aminopeptidase in urine by univariate study led to a method involving pretreatment of urine with Sephadex G50. Re-examination of the optimization by multivariate study led us to recommend higher optimal concentrations: 5.8 mmol/L for the substrate and 300 mmol/L for the Tris buffer. Under these new conditions, pretreatment of urine was no longer necessary and the assay could be completely automated.


Author(s):  
Turki Al-Khalifah ◽  
Abdul Aabid ◽  
Sher Afghan Khan ◽  
Muhammad Hanafi Bin Azami ◽  
Muneer Baig

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