Oxypertine and Medazepam in Patients Suffering from Anxiety Neurosis. Report of a Double Blind Study

In two centres a total of 50 patients with anxiety neurosis was studied in a randomised, between patient, double blind comparison of the therapeutic efficacies of two new anxiolytic agents, oxypertine ( Integrin) and medazepam ( Nobrium). Treatment was continued for four weeks. Assessments were made using the Middlesex Hospital Questionnaire ( MHQ), the Hamilton Anxiety Scale and the Graphic Scale. On all three ratings both agents produced a significant improvement in the patients' condition. Significant differences between the two agents were recorded by the MHQ sub tests and total score. Phobic anxiety responded significantly better to medazepam ( p < 0·03). Depression responded significantly better to oxypertine ( p < 0·02) which was also associated with a greater improvement in three of the remaining four sub tests and a significantly greater reduction in score for overall neuroticism ( p < 0·05).

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COMPARISONS BETWEEN ANXIOUS INHIBITION RATING SCALE (AIRS) AND HAMILTON ANXIETY SCALE IN DOUBLE BLIND STUDY OF ALPIDEM VS BROMAZEPAM STUDY.

Clinical Neuropharmacology ◽

10.1097/00002826-199202001-01061 ◽

1992 ◽

Vol 15 ◽

pp. 544B

Author(s):

M. Ohayon ◽

M. Caulet

Keyword(s):

Rating Scale ◽

Anxiety Scale ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Hamilton Anxiety Scale ◽

Hamilton Anxiety

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Topical Treatment of Eczema with Triamcinolone Acetonide Benzoyl-β-Amino-Isobutyrate: A Double-Blind Comparison with Betamethasone Dipropionate

Journal of International Medical Research ◽

10.1177/030006057700500311 ◽

1977 ◽

Vol 5 (3) ◽

pp. 207-212

Author(s):

F E Roessei

Keyword(s):

Triamcinolone Acetonide ◽

Topical Treatment ◽

Betamethasone Dipropionate ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Blind Comparison

The results are reported of a double-blind study of the topical efficacy of triamcinolone acetonide benzoyl-β-amino-isobutyrate (TBI), in 21 patients with symmetrically paired lesions of acute eczema. The effects were compared with those of betamethasone dipropionate. On the indication chosen, the two corticosteroids were equally efficacious; tolerance, also, was the same for both substances.

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A Three-Month Double-Blind Study of Clobazam versus Diazepam in Out-Patients Suffering from Neurotic Disturbances

Journal of International Medical Research ◽

10.1177/030006057900700513 ◽

1979 ◽

Vol 7 (5) ◽

pp. 404-410 ◽

Cited By ~ 1

Author(s):

H P Schjønsby ◽

A E Gordon ◽

D Koeppen

Keyword(s):

Global Assessment ◽

Anxiety Scale ◽

Double Blind Study ◽

Efficacy And Safety ◽

Double Blind ◽

Significant Difference ◽

Hamilton Anxiety Scale ◽

Period Data ◽

The Individual ◽

Hamilton Anxiety

Efficacy and safety of the 1,5 benzodiazepine, clobazam, in comparison to the 1,4 benzodiazepine, diazepam, were controlled in sixty psychiatric out-patients over a period of three months. In the course of this long treatment period data were obtained confirming findings of shorter-lasting studies. Global assessment of the therapeutic efficacy and the total scores of the Hamilton Anxiety Scale revealed no significant difference between the compounds. Both groups showed a significant (p < 0.01) improvement in the total scores of the Hamilton Anxiety Scale after two weeks of treatment. Scores of the individual items indicated distinct spectra of action: Clobazam was more effective in diminishing anxious mood, whereas diazepam was better able to influence muscular symptoms of anxiety. The relevance of the findings for a more individualized therapy is pointed out.

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