COMPARISONS BETWEEN ANXIOUS INHIBITION RATING SCALE (AIRS) AND HAMILTON ANXIETY SCALE IN DOUBLE BLIND STUDY OF ALPIDEM VS BROMAZEPAM STUDY.

Efficacy and safety of the 1,5 benzodiazepine, clobazam, in comparison to the 1,4 benzodiazepine, diazepam, were controlled in sixty psychiatric out-patients over a period of three months. In the course of this long treatment period data were obtained confirming findings of shorter-lasting studies. Global assessment of the therapeutic efficacy and the total scores of the Hamilton Anxiety Scale revealed no significant difference between the compounds. Both groups showed a significant (p < 0.01) improvement in the total scores of the Hamilton Anxiety Scale after two weeks of treatment. Scores of the individual items indicated distinct spectra of action: Clobazam was more effective in diminishing anxious mood, whereas diazepam was better able to influence muscular symptoms of anxiety. The relevance of the findings for a more individualized therapy is pointed out.

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Anxiolytic Efficacy of Alprazolam Compared to Diazepam and Placebo

Journal of International Medical Research ◽

10.1177/030006058000800207 ◽

1980 ◽

Vol 8 (2) ◽

pp. 139-143 ◽

Cited By ~ 19

Author(s):

Barry M Maletzky

Keyword(s):

Side Effects ◽

Rating Scale ◽

Blind Study ◽

Double Blind Study ◽

Symptom Scale ◽

Double Blind ◽

Self Rating ◽

Hamilton Anxiety Rating Scale ◽

Hamilton Anxiety

The anxiolytic effects of alpraxolam (0.5–3.0 mg), diazepam (5–60 mg) and placebo were evaluated in eighty-six out-patients suffering from moderate to severe psychoneurotic anxiety in this 28-day, double-blind study. Efficacy was evaluated using five rating instruments, three rated by the physician (Hamilton Anxiety Rating Scale, Physician's Global Impressions and Target Symptoms) and two by the patients (Self-Rating Symptom Scale and Patient's Global Impressions). Alprazolam was more effective than placebo on all five measures of efficacy and, on several parameters, more effective than diazepam as well. The incidence of side-effects was lowest in the alprazolam group and decreased steadily over the course of the study, whereas the incidence in the diazepam and placebo groups remained relatively unchanged.

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Oxypertine and Medazepam in Patients Suffering from Anxiety Neurosis. Report of a Double Blind Study

Journal of International Medical Research ◽

10.1177/030006057700500610 ◽

1977 ◽

Vol 5 (6) ◽

pp. 130-135

Author(s):

J F Donald ◽

W P McMillin

Keyword(s):

Anxiety Scale ◽

Blind Study ◽

Double Blind Study ◽

Anxiety Neurosis ◽

Double Blind ◽

Phobic Anxiety ◽

Two Agents ◽

Middlesex Hospital ◽

Hamilton Anxiety Scale ◽

Blind Comparison

In two centres a total of 50 patients with anxiety neurosis was studied in a randomised, between patient, double blind comparison of the therapeutic efficacies of two new anxiolytic agents, oxypertine ( Integrin) and medazepam ( Nobrium). Treatment was continued for four weeks. Assessments were made using the Middlesex Hospital Questionnaire ( MHQ), the Hamilton Anxiety Scale and the Graphic Scale. On all three ratings both agents produced a significant improvement in the patients' condition. Significant differences between the two agents were recorded by the MHQ sub tests and total score. Phobic anxiety responded significantly better to medazepam ( p < 0·03). Depression responded significantly better to oxypertine ( p < 0·02) which was also associated with a greater improvement in three of the remaining four sub tests and a significantly greater reduction in score for overall neuroticism ( p < 0·05).

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The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study

Medicina ◽

10.3390/medicina57010042 ◽

2021 ◽

Vol 57 (1) ◽

pp. 42

Author(s):

Ki Tae Jung ◽

Keum Young So ◽

Seung Un Kim ◽

Sang Hun Kim

Keyword(s):

Laparoscopic Cholecystectomy ◽

Infusion Rate ◽

Rating Scale ◽

Opioid Consumption ◽

Blind Study ◽

Double Blind Study ◽

Fixed Rate ◽

Double Blind ◽

Randomized Controlled ◽

Background Infusion

Background and objectives: The fixed-rate continuous background infusion mode with bolus dosing is a common modality for intravenous patient-controlled analgesia (PCA). However, some patients suffer from inadequate analgesia or opioid-related adverse effects due to the biphasic pattern of postoperative pain. Therefore, we investigated the postoperative analgesic efficacy of PCA using an optimizing background infusion mode (OBIM) where the background injection rate varies depending on the patient’s bolus demand. Materials and Methods: We prospectively enrolled 204 patients who underwent laparoscopic cholecystectomy in a randomized, controlled, double-blind study. Patients were allocated to either the optimizing (group OBIM) or the traditional background infusion group (group TBIM). The numeric rating scale (NRS) score for pain was evaluated at admission to and discharge from the recovery room, as well as at the 6th, 24th, and 48th postoperative hours. Data on bolus demand count, total infused volume, and background infusion rate were downloaded from the PCA device at 30-min intervals until the 48th postoperative hour. Results: The NRS score was not significantly different between groups throughout the postoperative period (p = 0.621), decreasing with time in both groups (p < 0.001). The bolus demand count was not significantly different between groups throughout (p = 0.756). The mean total cumulative infused PCA volume was lower in group OBIM (84.0 (95% confidence interval: 78.9−89.1) mL) than in group TBIM (102 (97.8−106.0) mL; p < 0.001). The total cumulative opioid dose in fentanyl equivalents, after converting sufentanil to fentanyl using an equipotential dose ratio, was lower in group OBIM (714.1 (647.4−780.9) μg) than in group TBIM (963.7 (870.5−1056.9) μg); p < 0.001). The background infusion rate was significantly different between groups throughout the study period (p < 0.001); it was higher in group OBIM than in group TBIM before the 12th postoperative hour and lower from the 18th to the 48th postoperative hour. Conclusions: The OBIM combined with bolus dosing reduces the cumulative PCA volume and opioid consumption compared to the TBIM combined with bolus dosing, while yielding comparable postoperative analgesia and bolus demand in patients undergoing laparoscopic cholecystectomy.

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Gambaran Tingkat Kecemasan Pasien Dewasa terhadaps Tindakan Pencabutan Gigi di Puskesmas Bahu Kecamatan Malalayang Kota Manado

e-GIGI ◽

10.35790/eg.1.2.2013.3115 ◽

2013 ◽

Vol 1 (2) ◽

Author(s):

Harfika Boky

Keyword(s):

Rating Scale ◽

Demographic Data ◽

Age Groups ◽

Anxiety Scale ◽

Patient Anxiety ◽

Anxiety Patient ◽

Hamilton Anxiety Scale ◽

Hamilton Anxiety Rating Scale ◽

Teeth Extraction ◽

Hamilton Anxiety

Kecemasan merupakan suatu keadaan yang normal dari manusia untuk menghadapi situasi tertentu, tetapi juga dapat berubah menjadi gangguan mental jika berlebihan dan tidak sebanding dengan situasi. Dalam bidang kedokteran gigi gejala kecemasan sering ditemukan pada pasien tindakan pencabutan gigi. Hal ini membuat peneliti tertarik untuk mengetahui "Gambaran tingkat kecemasan pasien terhadap tindakan pencabutan gigi di puskesmas Bahu Kecamatan Malalayang Kota Manado".Penelitian ini menggunakan metode penelitian crossectional studi dengan pengambilan data secara total sampling. Data penelitian dikumpulkan dengan mewawancarai responden dimana lembar skoring terdiri atas 2 bagian. Bagian pertama digunakan untuk mengidentifikasi data demografi.Bagian kedua digunakan untuk pengukuran tingkat kecemasan menggunakan skala HAM-A (Hamilton Anxiety Scale).Hasil penelitian menunjukan tingkat kecemasan pasien pencabutan gigi di puskesmas Bahu Kecamatan Malalayang Kota Manado berdasarkan penilaian Hamilton Anxiety Rating Scale yaitu sebanyak 27 orang (43,6%) dari total 62 subjek dinyatakan menderita kecemasan baik ringan maupun sedang. Pasien dengan jenis kelamin perempuan lebih banyak yang cemas dibandingkan dengan pasien dengan jenis kelamin laki-laki. Pasien usia 18-40 tahun lebih merasakan cemas dibandingkan kelompok usia yang lebih tua. Diharapkan operator lebih memperhatikan kecemasan pasien dan mengetahui bagaimana penangannya.Kata kunci : kecemasan, tindakan pencabutan gigiABSTRACTAnxiety is a normal condition of the human beeing to deal with certain situation, but it also can turn into mentally disorder, if excessive and not comparable. In dental, symptoms anxiety often found in teeth extraction patient. Anxiety experienced should have seriously attention because influence the performance of dentist. So researcher interested to know about "Description of the patient's level anxiety to teeth extraction at Puskesmas Bahu Kecamatan Malalayang Kota Manado".The reaserch use s a type of descriptive research, data is collected by interviewing the respondent where there are two sheets. The first sheet is used to identify the demographic data., the second part is used for the measurement of the level of anxiety HAM-A (Hamilton Anxiety Scale)Result show the leve of anxiety teeth extraction in Puskesmas Bahu Kecamatan Malalayang kota Manado based on assesment Hamilton anxiety rating scale is 27 patients (43,6%) from 62 total subject expressed suffer or moderate anxiety. Patient with gender women more anxious than men. Patient with ages 18-40 years are more anxious than older age groups. Sugest to spend more attention to anxiety patient and knowing the handling.Key word : Anxiety, teeth extraction

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Valproate (depakine-chrono) in the acute treatment of outpatients with generalized anxiety disorder without psychiatric comorbidity: Randomized, double-blind placebo-controlled study

European Psychiatry ◽

10.1016/j.eurpsy.2007.08.001 ◽

2008 ◽

Vol 23 (2) ◽

pp. 109-114 ◽

Cited By ~ 28

Author(s):

Nadir A. Aliyev ◽

Zafar N. Aliyev

Keyword(s):

Anxiety Disorder ◽

Anxiety Disorders ◽

Generalized Anxiety Disorder ◽

Anxiety Scale ◽

Generalized Anxiety ◽

Study Group ◽

Double Blind ◽

Double Blind Placebo ◽

Hamilton Anxiety Scale ◽

Hamilton Anxiety

AbstractObjectiveAnxiety disorders are highly prevalent in population of European countries. However, the effect of Valproate (depakine-chrono) on generalized anxiety disorder (GAD) has not been studied in a double-blind placebo-controlled design.MethodEighty patients (all men) were washout from the all medications. Each patient was randomized to receive either depakine-chrono (40 patients) for 6 weeks or matched placebo (40 patients) in a double-blind manner. Eligible participants, in addition to meeting the DSM-IV criteria for GAD and having a minimum score of 25 and more on the Hamilton Anxiety Scale, were required to be between 18 and 65 years. Response was defined as a 50% reduction in the Hamilton anxiety scale score. Response and side effects with depakine-chrono and placebo were compared by using analysis of variance (ANOVA) and chi-square tests. Six patients did not return for at least one subsequent assessment, leaving 74 patients (36 taking depakine-chrono and 38 taking placebo) in the valuables study group.ResultsTwenty six of the 36 depakine-chrono-treated participants responded by 6 weeks, versus six of the 38 placebo-treated participants (p < 0.001). The most common and problematic side effect in the depakine-chrono group was dizziness and nausea.ConclusionsThe authors believe this to be the first double-blind placebo-controlled randomization study to test the efficacy of a depakine-chrono in the management of anxiety disorders. They need to be replicated in a larger study group.

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Efficacy and Safety of PRC-063, Extended-Release Multilayer Methylphenidate in Adults with ADHD Including 6-Month Open-Label Extension

Journal of Attention Disorders ◽

10.1177/1087054719896853 ◽

2020 ◽

pp. 108705471989685

Author(s):

Margaret D. Weiss ◽

Ann C. Childress ◽

Graeme A.E. Donnelly

Keyword(s):

Adult Adhd ◽

Rating Scale ◽

Least Square ◽

Blind Study ◽

Double Blind Study ◽

Efficacy And Safety ◽

Open Label ◽

Double Blind ◽

Open Label Study ◽

Label Study

Objective: To evaluate the efficacy and safety of a 16-hr multilayer-release methylphenidate (PRC-063) in a community-based adult ADHD population. Method: In a double-blind study, 375 participants were randomized to one of four fixed doses of PRC-063 or placebo. The primary outcome was the ADHD-Rating Scale-5 (RS). The first 50% of double-blind completers were invited to participate in a 6-month dose-optimized open-label study to assess response and safety. Results: In total, 333 participants completed the double-blind trial; 184 entered the open-label study. PRC-063 produced greater symptom reduction in ADHD-RS-5 total score from baseline compared with placebo in the double-blind study (least-square [LS] mean = −4.7 [−7.7, −1.6], p = .003). The most frequent adverse events were headache, insomnia, and decreased appetite. No significant sleep quality impact was observed ( p = .123). Significant improvements in ADHD-RS-5 scores from baseline continued through the open-label study ( p < .0001), coincident with dose optimization. Conclusion: PRC-063 was well tolerated and significantly improved ADHD symptomatology in adults.

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A Double-Blind Study of Symmetrel (Amantadine Hydrochloride) in Parkinson's Disease

Journal of International Medical Research ◽

10.1177/030006057400200206 ◽

1974 ◽

Vol 2 (2) ◽

pp. 137-141 ◽

Cited By ~ 1

Author(s):

R T G Merry ◽

A W Galbraith

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Daily Living ◽

Rating Scale ◽

Controlled Trial ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Double Blind Placebo

A double-blind, placebo-controlled trial of Symmetrel for five months in Parkinson's Disease was performed. Using a daily living ability rating scale, a significant improvement amongst the less severely affected patients and a highly significant improvement of the severely affected patients receiving the drug was observed. The improvement of both groups was maintained for the duration of the study.

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A General Practitioner Study of Dothiepin and Amitriptyline

Journal of International Medical Research ◽

10.1177/030006057400200305 ◽

1974 ◽

Vol 2 (3) ◽

pp. 210-213 ◽

Cited By ~ 18

Author(s):

J Lambourn ◽

J A Rees

Keyword(s):

General Practitioner ◽

Side Effects ◽

Rating Scale ◽

Global Scale ◽

Blind Study ◽

Double Blind Study ◽

Depressant Effect ◽

Double Blind ◽

Significant Difference ◽

Unexpected Difference

Forty-one patients completed a four-week double-blind study comparing dothiepin and amitriptyline. The anti-depressant effect of the two drugs was measured by the Hamilton depression rating scale and a five-point global scale. Side-effects were recorded as mild, moderate or severe. Analysis of the results failed to demonstrate a statistically significant difference between the anti-depressant effect of the two drugs, but dothiepin was the favoured therapy in all assessments. Both drugs produced a significant improvement (p < 0·01) after only one week's therapy. The incidence and severity of side-effects were much less with dothiepin. An unexpected difference in the Hamilton scores at the end of the fourth week is to be investigated further.

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The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study

10.20944/preprints202012.0305.v1 ◽

2020 ◽

Author(s):

Ki Tae Jung ◽

Keum Young So ◽

Seung Un Kim ◽

Sang Hun Kim

Keyword(s):

Laparoscopic Cholecystectomy ◽

Infusion Rate ◽

Rating Scale ◽

Analgesic Efficacy ◽

Blind Study ◽

Double Blind Study ◽

Fixed Rate ◽

Double Blind ◽

Randomized Controlled ◽

Background Infusion

Background and objectives: Traditional intravenous, patient-controlled analgesia (PCA) uses a fixed-rate continuous background infusion mode. However, some patients suffer from inadequate analgesia or opioid-related adverse effects due to the biphasic pattern of postoperative pain. Therefore, we investigated the postoperative analgesic efficacy of PCA using an optimizing background infusion mode (OBIM), where the background injection rate varies depending on the patient's bolus demand. Materials and Methods: We prospectively enrolled 204 patients who underwent laparoscopic cholecystectomy in a randomized, controlled, double-blind study. Patients were allocated into either the optimizing (group OBIM) or the traditional background infusion group (group TBIM). The numeric rating scale (NRS) score for pain was evaluated at admission to and discharge from the recovery room, as well as at the 6th, 24th, and 48th postoperative hours. Data of bolus demand count, total infused volume, and background infusion rate was downloaded from the PCA device at 30-min intervals until the 48th postoperative hour. Results: The NRS score was not significantly different between groups throughout the postoperative period (P = 0.621), decreasing with time in both groups (P < 0.001). The bolus demand count was not significantly different between groups throughout (P = 0.756). The mean cumulative infused PCA volume was lower in group OBIM [84.0 (95% confidence interval: 78.9−89.1) mL) than in group TBIM [102 (97.8−106.0) mL] (P < 0.001). The background infusion rate was significantly different between groups throughout (P < 0.001); it was higher in group OBIM than in group TBIM before the 12th postoperative hour, and lower from the 18th to the 48th postoperative hours. Conclusions: The OBIM combined with bolus dosing is useful in that it reduces the cumulative PCA volume compared to the TBIM combined with bolus dosing, while yielding comparable postoperative analgesia and bolus demand in patients undergoing laparoscopic cholecystectomy.

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