A Comparative Clinical Trial of Mianserin (Norval®) and Amitriptyline in the Treatment of Depression in General Practice

1978 ◽  
Vol 6 (3) ◽  
pp. 199-206 ◽  
Author(s):  
J Eric Murphy ◽  
K M Bridgman
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Comparative Trial ◽  
Double Blind ◽  
Comparative Clinical Trial ◽  
Treatment Of Depression

A double-blind controlled comparative trial of mianserin (Norval®) and amitriptyline was conducted in general practice. Fifty-one patients were treated with amitriptyline and fifty-five with mianserin. The dosage for the first week was 25 mg t.d.s. for amitriptyline and 10 mg t.d.s. for mianserin, increasing to 50 mg t.d.s. and 20 mg t.d.s. respectively for the subsequent three weeks. Both drugs proved equally effective in relieving the symptoms of primary depression but mianserin showed a reduced incidence of side-effects which was statistically significant.

A Comparative Clinical Trial of Org GB 94 and Imipramine in the Treatment of Depression in General Practice

1975 ◽  
Vol 3 (4) ◽  
pp. 251-260 ◽  
Author(s):  
J E Murphy
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Treatment Period ◽  
Therapeutic Effect ◽  
Double Blind ◽  
Comparative Clinical Trial ◽  
Two Agents ◽  
Treatment Of Depression

A double-blind controlled comparative clinical trial of Org GB 94 and imipramine was conducted in general practice. Fifty-five patients were treated with Org GB 94 (60 mg daily) and fifty-four with imipramine (150 mg daily). In the doses employed both agents were equally effective in relieving depression over a four week treatment period. Tolerance of the two agents was similar. Although no statistically significant differences emerged, with regard to both therapeutic effect and some side-effects a trend in favour of Org GB 94 was apparent.

A Double-Blind Comparative Clinical Trial of Floctafenine and Four Other Analgesics Conducted in General Practice

1976 ◽  
Vol 4 (3) ◽  
pp. 179-182 ◽  
Author(s):  
D M Lomas ◽  
J Gay ◽  
R N Midha ◽  
D L Postlethwaite
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Analgesic Effect ◽  
Rank Order ◽  
Controlled Trial ◽  
The Other ◽  
Double Blind ◽  
Comparative Clinical Trial

Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics—floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine—were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.

A Comparative Trial of Opipramol and Chlordiazepoxide in the Treatment of Anxiety

1973 ◽  
Vol 1 (3) ◽  
pp. 145-150 ◽  
Author(s):  
K Jepson ◽  
G Beaumont
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Rating Scale ◽  
Comparative Trial ◽  
Anxiety Score ◽  
Double Blind ◽  
Somatic Anxiety ◽  
Daily Dose ◽  
The Difference

A daily dose of 200 mg of opipramol (Insidon, Geigy) and 30 mg of chlordiazepoxide (Librium, Roche) were compared in a clinical trial in general practice. The trial was double blind and a stratified randomisation technique was employed. Twenty four patients received opipramol and twenty six chlordiazepoxide for four weeks. A total anxiety score and separate ‘psychic’ anxiety and ‘somatic’ anxiety scores were recorded, using a rating scale initially and after two and four weeks treatment. No overall difference in efficacy was found between the two drugs—opipramol producing a 76% improvement and chlordiazepoxide 64% by the end of the study. There was no difference in the relief of psychic anxiety. Although opipramol appeared to give more relief of somatic anxiety, the difference was not statistically significant. Again although opipramol relieved more individual symptoms than chlordiazepoxide, none of the differences were significant. 70% of patients on opipramol and 74% of those on chlordiazepoxide were classified ‘better’ globally by both doctor and patient by the end of the trial. The total number of side effects recorded was similar on both drugs although drowsiness occurred twice as frequently on chlordiazepoxide as it did on opipramol.

Dibenzepin and Amitriptyline in the Treatment of Depression

1971 ◽  
Vol 118 (546) ◽  
pp. 523-524 ◽  
Author(s):  
M. Y. Ekdawi
Keyword(s):  
Side Effects ◽  
Antidepressant Drug ◽  
Comparative Trial ◽  
Tricyclic Antidepressant ◽  
Pharmacological Properties ◽  
Double Blind ◽  
Depressed Patients ◽  
Treatment Of Depression ◽  
Significant Difference

Dibenzepin hydrochloride is a new tricyclic antidepressant drug with pharmacological properties midway between those of imipramine and amitriptyline. In a double-blind comparative trial, J. M. Fielding (Med. J. Australia, 1969, 1, 614) found no significant difference in the speed of the effect of the two drugs in depressed patients. He reported that side-effects rated subjectively by patients were maximal before starting on the drugs and tended to decrease with time. The following trial was accordingly staged.

A Comparative Clinical Trial of Benorylate and Indomethacin in the Treatment of Active Rheumatoid Arthritis in General Practice

1974 ◽  
Vol 2 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Alastair Malcolm
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
General Practice ◽  
Active Rheumatoid Arthritis ◽  
Double Blind ◽  
Comparative Clinical Trial

Benorylate was compared with indomethacin in a double-blind cross-over trial in patients with rheumatoid arthritis. Twelve patients completed treatment. All measurements showed a trend towards benorylate giving greater improvement, although the differences were not statistically significant. Nine patients out of the twelve preferred benorylate.

A Comparative Trial of Minocin (Minocycline Hydrochloride) and Ampicillin in the Treatment of Acute Exacerbations of Chronic Bronchitis

1975 ◽  
Vol 3 (5) ◽  
pp. 304-308 ◽  
Author(s):  
G R F Burrow ◽  
A S Fox ◽  
R J E Daniel
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Chronic Bronchitis ◽  
Therapeutic Efficacy ◽  
Comparative Trial ◽  
Double Blind ◽  
Significant Difference ◽  
Acute Exacerbations ◽  
Minocycline Hydrochloride ◽  
Long Acting

One hundred and fifteen patients suffering from acute exacerbations of chronic bronchitis took part in a double-blind, multicentre, clinical trial designed to compare the therapeutic efficacy and tolerability of ampicillin and minocycline hydrochloride, a new, long-acting, semi-synthetic tetracycline. Both antibiotics were equally successful in treatment, there being no statistically significant difference between the two in any of the parameters studied. Side-effects were few and far between. Only one patient out of the 57 who took minocycline, complained of dizziness.

A Double-Blind Controlled Trial of ‘Vivalan’ (Viloxazine Hydrochloride) and Imipramine Hydrochloride in the Treatment of Depression in General Practice

1974 ◽  
Vol 2 (4) ◽  
pp. 260-264 ◽  
Author(s):  
P F C Bayliss ◽  
A R Dewsbury ◽  
J F Donald ◽  
J W Harcup ◽  
M Mayer ◽  
...  
Keyword(s):  
General Practice ◽  
Side Effects ◽  
General Practitioners ◽  
Side Effect ◽  
Controlled Trial ◽  
Depressive Illness ◽  
Double Blind ◽  
Patient Study ◽  
Treatment Of Depression ◽  
Imipramine Hydrochloride

One hundred and twenty-three patients with mild to moderate depressive illness were entered into a double-blind between-patient study of viloxazine hydrochloride (150 mg/day, expressed as base) and imipramine hydrochloride (75 mg/day, expressed as salt) by nine general practitioners. Sixty-two took viloxazine and sixty-one took imipramine. Both drugs produced a statistically highly significant improvement in both the depressive and anxiety symptoms over the period of the study, an effect being seen as early as the seventh day of treatment. Viloxazine produced fewer side-effects than imipramine, in particular significantly less drowsiness and dry mouth. The only side-effect seen with viloxazine was an upper gastro-intestinal disturbance with nausea and occasional vomiting, but this was transient. It is concluded that viloxazine hydrochloride is an effective anti-depressant in mild to moderate cases of depression in general practice and has the advantage of fewer side-effects than imipramine. The absence of sedation with viloxazine is of particular value in the treatment of ambulant patients.

A Comparative Trial of Desipramine and Nortriptyline in Depression

1968 ◽  
Vol 114 (509) ◽  
pp. 469-471 ◽  
Author(s):  
J. A. Stewart ◽  
P. H. Mitchell
Keyword(s):  
Clinical Trial ◽  
Great Britain ◽  
Side Effects ◽  
Comparative Trial ◽  
Endogenous Depression ◽  
Treatment Of Depression ◽  
Significant Difference

Seven drugs of the imino-dibenzyl group are now generally available in Great Britain (imipramine, amitriptyline, desipramine, nortriptyline, protriptyline, trimipramine and opipramol). All are similar in their actions and side-effects. Imipramine, the first to appear, has been shown to be more effective than placebo in the treatment of depression, though with much better results in men than in women (M.R.C. Clinical Trial, 1965). Desipramine, a metabolite of impramine, was introduced with the claim that its action was quicker than that of imipramine, though this has never been clearly demonstrated. Trials of desipramine against imipramine (Waldron and Bates, 1965; Rose and Westhead, 1964) showed no significant difference between these drugs. Comparison of amitriptyline and imipramine (Burt, Gordon, Holt and Hordern, 1962), showed amitriptyline to be at least as effective as imipramine and significantly superior in the treatment of endogenous depression. Comparisons of nortriptyline and amitriptyline (Forrest, Affleck, Gibb and Priest, 1964; Rose, Leahy, Martin and Westhead, 1965) showed no significant difference between these drugs.

A Comparative Trial of Opipramol with Phenelzine and Chlordiazepoxide in the Treatment of Depression

1974 ◽  
Vol 2 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Norman Capstick ◽  
Kenneth C Rooke
Keyword(s):  
General Practice ◽  
Comparative Trial ◽  
Double Blind Trial ◽  
Trial Period ◽  
Double Blind ◽  
Blind Trial ◽  
Treatment Of Depression ◽  
Significant Difference ◽  
Depressive States

A double-blind trial comparing the action of opipramol against a combination of phenelzine and chlordiazepoxide in the treatment of depressive states was carried out jointly in a psychiatric out-patient clinic and in a general practice. While both preparations were effective there was no statistically significant difference favouring one agent at the end of the six weeks trial period. Certain advantages occurred with each preparation at different times during the trial period, and these are described in the text.

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