A Double-Blind Comparative Clinical Trial of Floctafenine and Four Other Analgesics Conducted in General Practice

1976 ◽  
Vol 4 (3) ◽  
pp. 179-182 ◽  
Author(s):  
D M Lomas ◽  
J Gay ◽  
R N Midha ◽  
D L Postlethwaite
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Analgesic Effect ◽  
Rank Order ◽  
Controlled Trial ◽  
The Other ◽  
Double Blind ◽  
Comparative Clinical Trial

Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics—floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine—were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.

A Comparative Clinical Trial of Org GB 94 and Imipramine in the Treatment of Depression in General Practice

1975 ◽  
Vol 3 (4) ◽  
pp. 251-260 ◽  
Author(s):  
J E Murphy
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Treatment Period ◽  
Therapeutic Effect ◽  
Double Blind ◽  
Comparative Clinical Trial ◽  
Two Agents ◽  
Treatment Of Depression

A double-blind controlled comparative clinical trial of Org GB 94 and imipramine was conducted in general practice. Fifty-five patients were treated with Org GB 94 (60 mg daily) and fifty-four with imipramine (150 mg daily). In the doses employed both agents were equally effective in relieving depression over a four week treatment period. Tolerance of the two agents was similar. Although no statistically significant differences emerged, with regard to both therapeutic effect and some side-effects a trend in favour of Org GB 94 was apparent.

A Comparative Clinical Trial of Mianserin (Norval®) and Amitriptyline in the Treatment of Depression in General Practice

1978 ◽  
Vol 6 (3) ◽  
pp. 199-206 ◽  
Author(s):  
J Eric Murphy ◽  
K M Bridgman
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Comparative Trial ◽  
Double Blind ◽  
Comparative Clinical Trial ◽  
Treatment Of Depression

A double-blind controlled comparative trial of mianserin (Norval®) and amitriptyline was conducted in general practice. Fifty-one patients were treated with amitriptyline and fifty-five with mianserin. The dosage for the first week was 25 mg t.d.s. for amitriptyline and 10 mg t.d.s. for mianserin, increasing to 50 mg t.d.s. and 20 mg t.d.s. respectively for the subsequent three weeks. Both drugs proved equally effective in relieving the symptoms of primary depression but mianserin showed a reduced incidence of side-effects which was statistically significant.

A Comparative Trial of Opipramol and Chlordiazepoxide in the Treatment of Anxiety

1973 ◽  
Vol 1 (3) ◽  
pp. 145-150 ◽  
Author(s):  
K Jepson ◽  
G Beaumont
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Rating Scale ◽  
Comparative Trial ◽  
Anxiety Score ◽  
Double Blind ◽  
Somatic Anxiety ◽  
Daily Dose ◽  
The Difference

A daily dose of 200 mg of opipramol (Insidon, Geigy) and 30 mg of chlordiazepoxide (Librium, Roche) were compared in a clinical trial in general practice. The trial was double blind and a stratified randomisation technique was employed. Twenty four patients received opipramol and twenty six chlordiazepoxide for four weeks. A total anxiety score and separate ‘psychic’ anxiety and ‘somatic’ anxiety scores were recorded, using a rating scale initially and after two and four weeks treatment. No overall difference in efficacy was found between the two drugs—opipramol producing a 76% improvement and chlordiazepoxide 64% by the end of the study. There was no difference in the relief of psychic anxiety. Although opipramol appeared to give more relief of somatic anxiety, the difference was not statistically significant. Again although opipramol relieved more individual symptoms than chlordiazepoxide, none of the differences were significant. 70% of patients on opipramol and 74% of those on chlordiazepoxide were classified ‘better’ globally by both doctor and patient by the end of the trial. The total number of side effects recorded was similar on both drugs although drowsiness occurred twice as frequently on chlordiazepoxide as it did on opipramol.

A Comparative Clinical Trial of Benorylate and Indomethacin in the Treatment of Active Rheumatoid Arthritis in General Practice

1974 ◽  
Vol 2 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Alastair Malcolm
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
General Practice ◽  
Active Rheumatoid Arthritis ◽  
Double Blind ◽  
Comparative Clinical Trial

Benorylate was compared with indomethacin in a double-blind cross-over trial in patients with rheumatoid arthritis. Twelve patients completed treatment. All measurements showed a trend towards benorylate giving greater improvement, although the differences were not statistically significant. Nine patients out of the twelve preferred benorylate.

Can post-tonsillectomy pain be reduced by topical bupivacaine? Double blind controlled trial

1989 ◽  
Vol 103 (6) ◽  
pp. 592-593 ◽  
Author(s):  
N.S. Violaris ◽  
J.R. Tuffin
Keyword(s):  
Normal Saline ◽  
Analgesic Effect ◽  
Controlled Trial ◽  
Prospective Trial ◽  
The Other ◽  
Cent Solution ◽  
Double Blind ◽  
Tonsillar Fossa ◽  
Significant Difference ◽  
Adult Tonsillectomy

AbstractA double blind controlled prospective trial investigated the analgesic effect of topical Bupivacaine in 15 adult patients undergoing bilateral tonsillectomy. Each patient had one tonsillar fossa exposed to Bupivacaine 0.5 per cent solution and the other to normal saline. When visited four to six hours post-operatively, 12 out of 15 patients (80 per cent) stated that the Bupivacaine exposed side to be more uncomfortable than the saline exposed side. On the first post-operative mornning 9 out of 15 patients (60 per cent) confirmed the same. The remaining patients were unable to detect a significant difference and no patient found the Bupivacaine side to be more comfortable.These results suggest that topical Bupivacaine 0.5 per cent solution has no place in providing post-operative analgesia in adult tonsillectomy.

Treatment of Arthritis in General Practice A Comparison between Benorylate and Indomethacin

1973 ◽  
Vol 1 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Gabriel Jaffé
Keyword(s):  
General Practice ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind

In a double-blind controlled trial two groups of 40 patients with rheumatoid or osteo-arthritis were treated for two weeks with indomethacin or benorylate. Benorylate was as effective as indomethacin in relieving symptoms but side effects were substantially less.

A Clinical Trial of the Efficacy and Acceptability of d-Fenfluramine in the Treatment of Neuroleptic-induced Obesity

1988 ◽  
Vol 153 (2) ◽  
pp. 208-213 ◽  
Author(s):  
E. Goodall ◽  
Christine Oxtoby ◽  
Ray Richards ◽  
Gill Watkinson ◽  
David Brown ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Side Effects ◽  
Mental State ◽  
Controlled Trial ◽  
Dietary Advice ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Schizophrenic Patients ◽  
Depot Neuroleptic

Twenty-nine overweight schizophrenic patients maintained on depot neuroleptic injections who wished to lose weight took part in a double-blind, placebo-controlled trial of 30 mg d-fenfluramine. All subjects received dietary advice. Sixteen patients completed the 12-week trial. Rate of weight loss was significantly greater in those taking d-fenfluramine. Side-effects were reported, but no deterioration in mental state was noted.

A Double-Blind Controlled Trial of ‘Vivalan’ (Viloxazine Hydrochloride) and Imipramine Hydrochloride in the Treatment of Depression in General Practice

1974 ◽  
Vol 2 (4) ◽  
pp. 260-264 ◽  
Author(s):  
P F C Bayliss ◽  
A R Dewsbury ◽  
J F Donald ◽  
J W Harcup ◽  
M Mayer ◽  
...  
Keyword(s):  
General Practice ◽  
Side Effects ◽  
General Practitioners ◽  
Side Effect ◽  
Controlled Trial ◽  
Depressive Illness ◽  
Double Blind ◽  
Patient Study ◽  
Treatment Of Depression ◽  
Imipramine Hydrochloride

One hundred and twenty-three patients with mild to moderate depressive illness were entered into a double-blind between-patient study of viloxazine hydrochloride (150 mg/day, expressed as base) and imipramine hydrochloride (75 mg/day, expressed as salt) by nine general practitioners. Sixty-two took viloxazine and sixty-one took imipramine. Both drugs produced a statistically highly significant improvement in both the depressive and anxiety symptoms over the period of the study, an effect being seen as early as the seventh day of treatment. Viloxazine produced fewer side-effects than imipramine, in particular significantly less drowsiness and dry mouth. The only side-effect seen with viloxazine was an upper gastro-intestinal disturbance with nausea and occasional vomiting, but this was transient. It is concluded that viloxazine hydrochloride is an effective anti-depressant in mild to moderate cases of depression in general practice and has the advantage of fewer side-effects than imipramine. The absence of sedation with viloxazine is of particular value in the treatment of ambulant patients.

A Clinical Trial of Hydroxyethylrutosides in the Treatment of Haemorrhoids of Pregnancy

1992 ◽  
Vol 20 (1) ◽  
pp. 54-60 ◽  
Author(s):  
H Wijayanegara ◽  
JC Mose ◽  
L Achmad ◽  
R Sobarna ◽  
W Permadi
Keyword(s):  
Clinical Trial ◽  
Treatment Group ◽  
Side Effects ◽  
Active Treatment ◽  
Controlled Trial ◽  
Active Treatment Group ◽  
Subjective Symptoms ◽  
Drug Related Problems ◽  
Double Blind ◽  
Safety And Efficacy

The safety and efficacy of 500 mg O-( β-hydroxyethyl)rutosides given orally twice daily in the treatment of 97 patients with first-, second-, or third-degree haemorrhoids were investigated in a double-blind, randomized placebo-controlled trial. The rutosides produced a significant ( P < 0.001) improvement in patient-assessed subjective symptoms (pain, bleeding, exudation and pruritus) compared with placebo. There was also a significant ( P < 0.0001) improvement in clinician-assessed subjective and objective signs (bleeding, inflammation and dilatation of the haemorrhoidal plexus) after 2 and 4 weeks' treatment compared with placebo. There were three mild, transient side-effects reported in the active treatment group and no drug-related problems in the pregnancy or delivery were observed. The results suggest that O-( β-hydroxyethyl)rutosides provide a safe and effective treatment for women with haemorrhoids of pregnancy.

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled
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