Nasopharyngeal Carcinoma with Extensive Nodular Skin Metastases: A Case Report

2006 ◽  
Vol 92 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Murat Caloglu ◽  
Kazim Uygun ◽  
Semsi Altaner ◽  
Cem Uzal ◽  
Zafer Kocak ◽  
...  
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Clinical Finding ◽  
Skin Metastasis ◽  
Skin Metastases ◽  
Skin Nodules ◽  
Undifferentiated Nasopharyngeal Carcinoma

Skin metastasis from nasopharyngeal carcinoma is a rare clinical finding. The most common form of appearance is a few solitary skin nodules. However, massive and extensive nodular dissemination or diffuse dermal lymphatic infiltration is extremely rare. We here present a case of a 40-year-old man with widespread nodular skin metastases from undifferentiated nasopharyngeal carcinoma.

scholarly journals Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Theresa M. Gille ◽  
Edward F. Miles ◽  
Allen O. Mitchell
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Local Excision ◽  
Wide Local Excision ◽  
Perineural Invasion ◽  
Chemoradiation Therapy ◽  
Regional Recurrence ◽  
Review Of The Literature ◽  
Positive Margins ◽  
Undifferentiated Nasopharyngeal Carcinoma

Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm microscopically similar to undifferentiated nasopharyngeal carcinoma. It is typically nonaggressive and is treated with wide local excision. However, we present a case of a patient with a regional recurrence and more aggressive LELCS with perineural invasion and positive margins for which he was treated with wide local excision followed by chemoradiation. We discuss the use of chemoradiation for this patient and review the literature, specifically pertaining to treatment of more aggressive cases of LELCS.

Painful ophthalmoplegia secondary to nasopharyngeal carcinoma: a case report

1990 ◽  
Vol 4 (2) ◽  
pp. 112
Author(s):  
Young Bae Roh ◽  
Jhoon Ho Kim ◽  
Joo Young Song ◽  
Boo Sup Oum
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Painful Ophthalmoplegia

Will Re-irradiation Alone Prevent Loco-regional Progression in Isolated Nodal Recurrence of Nasopharyngeal Carcinoma? - A Case Report

2017 ◽  
Vol 4 (5) ◽  
Author(s):  
Sasikala Prabaharan ◽  
Sasikala Prabaharan ◽  
Praveen Kumar Marimuthu ◽  
Sarath Chandra Reddy ◽  
Sarath Chandra Reddy ◽  
...  
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Nodal Recurrence

A Rare Case Report of Skin Metastasis in Gastric Cancer

2021 ◽  
Author(s):  
Mustafa Şahin ◽  
Ferhat Ekinci ◽  
Cumali Çelik ◽  
Peyker Temiz ◽  
Atike Pınar Erdoğan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Rare Case ◽  
Skin Metastasis ◽  
Rare Case Report

Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature

2020 ◽  
Vol 23 (6) ◽  
pp. 448-452
Author(s):  
Francesco Pontoriero ◽  
Ayaka M Silverman ◽  
Judy M Pascasio ◽  
Renu Bajaj
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Xenograft Model ◽  
Short Review ◽  
Undifferentiated Carcinoma ◽  
World Health ◽  
Surface Epithelium ◽  
Barr Virus ◽  
Cytogenetic Aberration ◽  
Health Organization

Carcinoma originating from the surface epithelium of the nasopharynx is classified by the World Health Organization (WHO) as nasopharyngeal carcinoma (NPC) and has 3 main types: keratinizing squamous cell carcinoma (WHO type 1) and nonkeratinizing carcinoma, differentiated (WHO type II), and undifferentiated (WHO type III). Nonkeratinizing NPC is strongly associated with prior Epstein–Barr virus (EBV) infection. These tumors may be divided into differentiated and undifferentiated carcinoma. Histologically, the tumor is characterized by syncytia of large malignant cells with vesicular nuclei, conspicuous nucleoli, and easily observed mitotic figures. We report a case of a 14-year-old boy diagnosed with EBV and human papillomavirus (HPV)-positive NPC (WHO type 3) with cytogenetics showing the presence of mosaic trisomy 2. This case report brings to light a rare cytogenetic aberration to our knowledge only reported once before in the literature in a xenograft model.

scholarly journals High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

Oncogene ◽  
2000 ◽  
Vol 19 (30) ◽  
pp. 3439-3444 ◽  
Author(s):  
Tim Crook ◽  
John M Nicholls ◽  
Louise Brooks ◽  
Jenny O'Nions ◽  
Martin J Allday
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
High Level Expression ◽  
High Level ◽  
Undifferentiated Nasopharyngeal Carcinoma

Carboplatin plus Taxol is an Effective Third-line Regimen in Recurrent Undifferentiated Nasopharyngeal Carcinoma

2002 ◽  
Vol 88 (4) ◽  
pp. 273-276 ◽  
Author(s):  
Mario Airoldi ◽  
Fulvia Pedani ◽  
Sara Marchionatti ◽  
Anna Maria Gabriele ◽  
Giovanni Succo ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Median Overall Survival ◽  
Low Dose ◽  
Recurrent Disease ◽  
Nasopharyngeal Cancer ◽  
First Line ◽  
Second Line Therapy ◽  
Previously Treated ◽  
Third Line ◽  
Undifferentiated Nasopharyngeal Carcinoma

Background Recurrent undifferentiated nasopharyngeal carcinoma is a chemosensitive disease. Few third-line treatments have been reported. Methods Twelve patients (9 males, 3 females; median age 50 years, range, 20-62) with recurrent undifferentiated nasopharyngeal carcinoma were treated with carboplatin AUC 5.5 + paclitaxel (175 mg/m2, 3-hr infusion) on day 1 every 3 weeks. All patients had been previously treated for recurrent disease with a first-line cisplatin-based chemotherapy and a second-line therapy with low-dose continous infusion 5-fluorouracil. Results Overall, 54 courses were given (median, 5; range, 2-6). Three patients (25%) obtained a partial response lasting 6, 10 and 26+ months, 1 (8.3%) a minimal response lasting 6 months, and 3 (25%) no change with a median duration of 5 months. The median survival time was 14 months for patients who had a partial or minimal response or no change, and 5 months for nonresponders. Median overall survival was 9.5 months (3-30+). The treatment was well tolerated, and toxicity was manageable. Conclusions The combination has a good pallitive role as third-line chemotherapy in recurrent undifferentiated nasopharyngeal cancer.

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