Correlation between Levels of Dehydroepiandrosterone-Sulphate and Prolactin in Human Breast Cyst Fluid

Concentration of dehydroepiandrosterone sulphate (DHAS), cortisol (F), aldosterone (A) and prolactin (PRL) were measured in 70 samples of breast cyst fluid (BCF) obtained by needle aspiration from patients having gross cystic disease of the breast. DHAS concentrations in our series of BCF were scattered over a broad range, up to values 200-fold higher than in plasma, with ample interindividual variability; Cortisol was present in BCF in very small amounts. Aldosterone and PRL values were in the same order of plasma levels; moreover, a significant correlation was found between DHAS and PRL concentrations in BCF.

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Relationship between cations and dehydroepiandrosterone sulphate in human breast cyst fluid

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(86)90793-4 ◽

1986 ◽

Vol 25 ◽

pp. 126

Author(s):

F. Orlandi ◽

L. Dogliotti ◽

M. Torta ◽

A. Angeli

Keyword(s):

Cyst Fluid ◽

Dehydroepiandrosterone Sulphate ◽

Human Breast ◽

Breast Cyst Fluid ◽

Breast Cyst

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Estroe-3-Sulfate in Human Breast Cyst Fluid

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1990.tb34335.x ◽

1990 ◽

Vol 595 (1 Steroid Forma) ◽

pp. 464-466 ◽

Cited By ~ 4

Author(s):

F. Orlandi ◽

P. Caraci ◽

B. Puligheddu ◽

M. Torta ◽

L. Dogliotti ◽

...

Keyword(s):

Cyst Fluid ◽

Human Breast ◽

Breast Cyst Fluid ◽

Breast Cyst

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Insulin-Like (IGF-I, IGF-II), Epidermal (EGF) and Alpha Transforming (TGF-α) Growth Factors in Human Breast Cyst Fluid (BCF)

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury ◽

10.1007/978-1-4615-3520-1_93 ◽

1993 ◽

pp. 471-474

Author(s):

D. Y. Wang ◽

W. H. Harris ◽

I. S. Fentiman ◽

H. Hamed ◽

W. R. Miller

Keyword(s):

Growth Factors ◽

Cyst Fluid ◽

Human Breast ◽

Breast Cyst Fluid ◽

Breast Cyst ◽

Igf I

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Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast

Cancer ◽

10.1002/1097-0142(19830401)51:7<1297::aid-cncr2820510720>3.0.co;2-z ◽

1983 ◽

Vol 51 (7) ◽

pp. 1297-1302 ◽

Cited By ~ 35

Author(s):

John S. Silva ◽

Gregory S. Georgiade ◽

William G. Dilley ◽

Kenneth S. McCarty ◽

Samuel A. Wells ◽

...

Keyword(s):

Menstrual Cycle ◽

Steroid Receptors ◽

Cyst Fluid ◽

Sex Steroid ◽

Human Breast ◽

Breast Cyst Fluid ◽

Breast Cyst ◽

Normal Human Breast ◽

Normal Human ◽

Cycle Dependent

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Human Glandular Kallikrein in Breast Milk, Amniotic Fluid, and Breast Cyst Fluid

Clinical Chemistry ◽

10.1093/clinchem/45.10.1774 ◽

1999 ◽

Vol 45 (10) ◽

pp. 1774-1780 ◽

Cited By ~ 24

Author(s):

Angeliki Magklara ◽

Andreas Scorilas ◽

Carlos López-Otín ◽

Francisco Vizoso ◽

Alvaro Ruibal ◽

...

Keyword(s):

Breast Cancer ◽

Amniotic Fluid ◽

Biological Fluids ◽

Cyst Fluid ◽

Cystic Disease ◽

Breast Cyst Fluid ◽

Breast Cyst ◽

Glandular Kallikrein ◽

Female Breast

Abstract Background: Human glandular kallikrein (hK2) belongs to the serine protease family of enzymes and has high sequence homology with prostate-specific antigen (PSA). The physiological role of hK2 has not as yet been determined, but there is evidence that it can regulate the proteolytic activity of PSA through processing and activating pro-PSA, an inactive precursor. Thus, it is conceivable that these two secreted proteins may coexist in biological fluids. Currently, hK2 is considered an androgen-regulated and prostate-specific protein. Recently, it has been demonstrated that hK2 is expressed in the breast cancer cell line T-47D after stimulation by steroid hormones, and we reported that hK2 can be detected in a subset of breast tumor extracts. These data suggest that hK2 may be expressed in tissues other than the prostate, such as those in which PSA has already been detected. Because hK2 is a secreted protein, it may be present in various biological fluids. Methods: We analyzed milk samples from lactating women, amniotic fluid from pregnant women, and breast cyst fluid from patients with gross breast cystic disease, using a highly sensitive and specific immunoassay for hK2. Results: hK2 was present in all three biological fluids. We suggest that the female breast may produce hK2 and provide evidence that hK2 may have value as an additional marker for the discrimination between type I and type II breast cysts. Conclusions: The female breast produces hK2 in addition to PSA. More studies are necessary to establish the role of this kallikrein in nondiseased breast, gross breast cystic disease, and breast cancer.

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