Thyroid Function in Gestational Trophoblastic Tumors

1986 ◽  
Vol 72 (2) ◽  
pp. 205-209
Author(s):  
Franca Vergadoro ◽  
Laura Tabacchi ◽  
Pietro Barbacini ◽  
Laura Vassena ◽  
Flavia Zanaboni ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Free T4 ◽  
Free T3 ◽  
Normal Limits ◽  
Trophoblastic Tumors

Thyroid function was assessed in a total of 15 cases, 7 of whom had choriocarcinoma and 8 hydatidiform mole, by measuring free T3, free T4, thyroxin-binding globulin (TBG), basal thyroid-stimulating hormone (TSH) and after the thyrotropin-releasing hormone test (ΔTSH). Free T3, free T4 and TBG were investigated in the same number of healthy women within the first three months of pregnancy. Only 13.4% of the cases presented elevated levels of free T3 and T4 and TBG; TSH and ΔTSH were within normal limits. Both thyroid hormones and TBG returned to within normal limits when β-human chorionic gonadotropin became undetectable. One patient was found to be hypothyroid. Comparison with the control group showed no significant differences except in TBG levels, which were higher in controls. A significant, direct correlation was found between levels of free T3 and T4 and TBG and the pattern of human chorionic gonadotropin.

scholarly journals Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
René Rodríguez-Gutiérrez ◽  
Jesús Zacarías Villarreal-Pérez ◽  
Felipe Arturo Morales-Martinez ◽  
René Rodríguez-Guajardo ◽  
Gloria González-Saldivar ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Strong Correlation ◽  
Hydatidiform Mole ◽  
Free Testosterone ◽  
Dehydroepiandrosterone Sulfate ◽  
Controlled Study ◽  
Control Group ◽  
The Difference ◽  
Prospective Longitudinal

Background. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered.Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM).Results. All participants completed the study. Before HM evacuation mean hCG was markedly higher in the cases than in the control group (P≤0.001). Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 ± 1.24 pg/mL and 231.50 ± 127.20 μ/dL) when compared to the control group (1.50 ± 0.75 pg/mL and 133.59 ± 60.69 μ/dL) (P=0.0001and 0.001), respectively. There was a strong correlation between hCG and free T/total T/DHEA-S concentrations (r=0.78;P≤0.001,r=0.74;  P≤0.001, andr=0.71;  P≤0.001), respectively. In the cases group 48 hours after HM evacuation, hCG levels were found to be significantly lower when compared to initial levels (P=0.001) and free T and DHEA-S declined significantly (P=0.0002and 0.009).Conclusion. Before uterus evacuation, hCG, free T, and DHEA-S levels were significantly higher when compared with controls finding a strong correlation between hCG and free T/DHEA-S levels. Forty-eight hours after HM treatment hCG levels declined and the difference was lost. A novel finding of our study is that in cases, besides free T, DHEA-S was also found to be significantly higher and both the ovaries and adrenal glands appear to be the sites of this androgen overproduction.

Analysis of 309 Cases after Hydatidiform Mole: Different Follow-Up Program According to Biologic Behavior

1988 ◽  
Vol 74 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Giorgio Bolis ◽  
Carlo Belloni ◽  
Cristina Bonazzi ◽  
Giorgia Mangili ◽  
Mauro Presti ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Selection Criteria ◽  
Hydatidiform Mole ◽  
Spontaneous Remission ◽  
Obstetrics And Gynecology ◽  
Surveillance Program ◽  
Beta Human Chorionic Gonadotropin ◽  
Trophoblastic Tumors

Between 1976 and 1985, at the Obstetrics and Gynecology Department of Milan University, a total of 309 cases of hydatidiform mole, 223 complete moles and 86 partial moles, were monitored with the assay of beta-human chorionic gonadotropin, following a postmolar biochemical surveillance program. Spontaneous remission of the disease occurred in 287 (92.9%) patients. Marker levels were undetectable in 80.4 % of cases within 60 days after evacuation of the mole and in 19.6% between 61 and 140 days. There were 22 (7.1%) patients diagnosed as having gestational trophoblastic tumors (GTT) and treated with chemotherapy: 20 were complete moles and 2 partial moles. Considering these data, the authors suggest different follow-up times for partial and complete moles and confirm the necessity of selection criteria in a diagnosis of GTT.

Human Chorionic Gonadotropin and Thyroid Function in Patients with Hydatidiform Mole

1985 ◽  
Vol 40 (8) ◽  
pp. 524-525
Author(s):  
SYED M. AMIR ◽  
RAPIN OSATHANONDH ◽  
ROSS S. BERKOWITZ ◽  
DONALD P. GOLDSTEIN
Keyword(s):  
Thyroid Function ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole

Human chorionic gonadotropin and thyroid function in patients with hydatidiform mole

1984 ◽  
Vol 150 (6) ◽  
pp. 723-728 ◽  
Author(s):  
Syed M. Amir ◽  
Rapin Osathanondh ◽  
Ross S. Berkowitz ◽  
Donald P. Goldstein
Keyword(s):  
Thyroid Function ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole

Prevalence of thyroid dysfunction and effect of contrast medium on thyroid metabolism in cardiac patients undergoing coronary angiography

2013 ◽  
Vol 54 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Paolo Marraccini ◽  
Massimiliano Bianchi ◽  
Antonio Bottoni ◽  
Alessandro Mazzarisi ◽  
Michele Coceani ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Contrast Medium ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
Low T3 Syndrome ◽  
Free T4 ◽  
Free T3 ◽  
Iodinated Contrast ◽  
Low T3

Background Iodinated contrast media (CM) may influence thyroid function. Precautions are generally taken in patients with hyperthyroidism, even if subclinical, whereas the risks in patients with hypothyroidism or low triiodothyronine (T3) syndrome are not considered as appreciable. Purpose To assess the presence and type of thyroid dysfunction in patients admitted for coronary angiography (CA), to assess the concentration of free-iodide in five non-ionic CM, and to evaluate changes in thyroid function after CA in patients with low T3 syndrome. Material and Methods We measured free T3, free thyroxine (T4), and thyroid-stimulating hormone (TSH) in 1752 consecutive patients prior to CA and free-iodide in five non-ionic CM. Urinary free-iodide before and 24 h after CA, and thyroid hormone profile 48 h after CA were also made in 17 patients with low T3 syndrome. Patients were followed up for an average duration of 63.5 months. Results The patients were divided into four groups: euthyroidism (60%), low T3 syndrome (28%), hypothyroidism (10%), and hyperthyroidism (2%). The free-iodide resulted far below the recommended limit of 50 μg/mL in all tested CM. In low T3 syndrome, 24-h free-iodide increased after CA from 99.9± 63 ug to 12276±9285 ug (P< 0.0001). A reduction in TSH (4.97±1.1 vs. 4.17±1.1 mUI/mL, P < 0.01) and free T3 (1.44±0.2 vs. 1.25±0.3 pg/mL, P < 0.01), with an increase in free T4 (11.3±2.9 vs. 12.5±3.4 pg/dL, P < 0.001), was found. Patients with functional thyroid disease in the follow-up had a significant lower rate survival compared to euthyroid patients (90.7 vs. 82.2%, P < 0.00001). Conclusion Thyroid dysfunction is frequent in patients who perform a CA, and low T3 syndrome is the predominant feature. The administration of contrast medium may further compromise the thyroid function.

scholarly journals Human chorionic gonadotropin (hCG) beta-core fragment is produced by degradation of hCG or free hCG beta in gestational trophoblastic tumors: a possible marker for early detection of persistent postmolar gestational trophoblastic disease

2001 ◽  
Vol 171 (3) ◽  
pp. 435-443 ◽  
Author(s):  
T Okamoto ◽  
K Matsuo ◽  
R Niu ◽  
M Osawa ◽  
H Suzuki
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Culture Media ◽  
Hydatidiform Mole ◽  
Subsequent Development ◽  
Gestational Trophoblastic Disease ◽  
Gel Chromatography ◽  
Trophoblastic Disease ◽  
Core Fragment ◽  
Trophoblastic Tumors

The present study was undertaken to investigate whether human chorionic gonadotropin (hCG) beta-core fragment (hCG beta cf) was directly produced by gestational trophoblastic tumors. Immunoreactivity of hCG beta cf was demonstrated in the extracts as well as in the culture media of hydatidiform mole tissues. It was also present in the extracts of choriocarcinoma tissues, and its molar concentration exceeded that of intact hCG. The presence of hCG beta cf was then confirmed by gel chromatography and Western blot analysis. Immunohistochemistry showed localization of hCG beta cf immunoreactivity to the syncytiotrophoblasts and scattered cells in the stroma of mole tissue, and to syncytiotrophoblastic cells in choriocarcinoma. Immunoreactivity of hCG beta cf was also detected in the sera of the patients with gestational trophoblastic disease, although the hCG beta cf/hCG ratio was less than one hundredth of that in the tissue extracts. Serial measurement of serum hCG beta cf levels after mole evacuation showed that they declined much more rapidly than those of hCG and became undetectable in the patients with subsequent spontaneous resolution, while hCG beta cf remained or became detectable before the rise of hCG was observed in the patients with subsequent persistent trophoblastic disease. Taken together, these results suggest that hCG beta cf is directly produced by gestational trophoblastic tumors, and monitoring of hCG beta cf in the serum after mole evacuation may be useful for early prediction of subsequent development of postmolar persistent trophoblastic disease.

A case of a hydatidiform mole in a 56-year-old woman

2005 ◽  
Vol 15 (1) ◽  
pp. 163-166
Author(s):  
C. A. R. Lok ◽  
A. F. ZüRCHER ◽  
J. Van Der Velden
Keyword(s):  
Risk Factors ◽  
Older Women ◽  
Thyroid Function ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Older Patients ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Trophoblastic Disease ◽  
Proper Diagnosis

A case of a 56-year-old woman with a mole pregnancy and a human chorionic gonadotropin (HCG)-induced thyreotoxicosis is presented. A proper diagnosis was only made after a period of patient and doctor's delay. After performing a hysterectomy, the HCG quickly normalized. Thyroid function normalized with thiamazol treatment. It is well known that older women have a higher risk to develop gestational trophoblastic disease (GTD). Furthermore, the chance of persistent trophoblastic disease is increased in this population. The literature on risk factors for developing persistent GTD and the possibilities for treatment in older patients is reviewed.

Thyroid Function Tests in Uremic Patients on Maintenance Dialysis: A Comparison of CAPD and Hemodialysis

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 27-29 ◽  
Author(s):  
Chaim Chary Tan ◽  
Benjamin Thysen ◽  
Michael Gatz ◽  
Ruth Freeman ◽  
Bertram E. Alpert
Keyword(s):  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Maintenance Hemodialysis ◽  
Thyroid Function Tests ◽  
Free T4 ◽  
Reverse T3 ◽  
Antibody Technique ◽  
Normal Limits ◽  
Function Tests

Thyroid function tests were performed in nine clinically euthyroid, chronic-renal-failure (CRF) patients on continuous ambulatory peritoneal dialysis (CAPD), and the results were compared with similar tests performed on normal controls and eight patients on maintenance hemodialysis (HD). As reported earlier in untreated patients with CRF and those maintained on HD, our patients on CAPD had markedly reduced total tri-iodothyronine (T3) concentration. Levels of serum thyroxine (T4), and serum free T4 estimated by the microencapsulated antibody technique were reduced in both groups of patients but were in the hypothyroid range only in the HD group. However, in keeping with the clinically euthyroid status of these patients, thyroid stimulating hormone levels were within normal limits. Finally, both groups of patients had low normal reverse T3 levels. These data confirm the presence of abnormalities in in vivo thyroid function tests in patients with CRF maintained by different modes of dialysis. The significance and mechanism of these abnormalities remains speculative.

Abnormalities in thyroid function associated with chronic therapy with methadone.

1988 ◽  
Vol 34 (11) ◽  
pp. 2202-2204 ◽  
Author(s):  
T N English ◽  
D Ruxton ◽  
C J Eastman
Keyword(s):  
Thyroid Function ◽  
Methadone Maintenance ◽  
Methadone Maintenance Therapy ◽  
Control Group ◽  
Thyroid Function Tests ◽  
Free T4 ◽  
Normal Limits ◽  
Chronic Therapy ◽  
Total Triiodothyronine ◽  
The Mean

Abstract We studied 145 clinically euthyroid patients on maintenance methadone therapy for narcotic withdrawal, to characterize abnormalities in thyroid-function tests induced by methadone. About a third had increased total thyroxin (T4) and total triiodothyronine (T3) concentrations in serum. The mean concentrations of T3, T4, and thyroxin-binding globulin (TBG) in serum were significantly greater (P less than 0.001 each) in these patients than in a euthyroid control group. There was a corresponding decrease in the T3 uptake (T3U) test, but the free thyroxin index (FTI) failed to correct for the increased TBG concentration in 15.9% of the patients. Individual and mean concentrations of free T3 (FT3) and free T4 (FT4) in serum and results of an "ultrasensitive" test for thyrotropin (TSH-IRMA) were within normal limits and confirmed the euthyroid state. We conclude that prolonged therapy with methadone causes increases in TBG, T3, and T4 in serum. FT3, FT4, and TSH-IRMA estimations are recommended as the diagnostic thyroid tests to use for patients on methadone maintenance therapy.

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