Granular Cell Basal Cell Carcinoma of the Skin. Report of a Case with Immunocytochemical Positivity for Lysozyme

1997 ◽  
Vol 83 (3) ◽  
pp. 712-714 ◽  
Author(s):  
Amedeo Boscaino ◽  
Luigi Tornillo ◽  
Pasquale Orabona ◽  
Stefania Staibano ◽  
Raffaella Gentile ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Rare Variant ◽  
Basal Cell ◽  
Granular Cell ◽  
The Body ◽  
First Time

Granular cell tumors have been described in many sites throughout the body. To our knowledge, few cases have been described in the literature. We report here the sixth case, in which positivity for lysozyme was also observed for the first time. The problems of the histogenesis and differential diagnosis of this rare variant of basal cell carcinoma are also discussed.

Basosquamous or Basal Cell Carcinoma? The Importance of the Differential Diagnosis

2015 ◽  
Vol 26 (6) ◽  
pp. 2026-2027 ◽  
Author(s):  
Valentina Terenzi ◽  
Andrea Cassoni ◽  
Marco M Della ◽  
Daniela Musio ◽  
Francesca De Felice ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell

CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma

2018 ◽  
Vol 27 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Cem Leblebici ◽  
Buket Bambul Sığırcı ◽  
Canan Kelten Talu ◽  
Sevim Baykal Koca ◽  
Gülben Erdem Huq
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
The Other ◽  
Cytokeratin 20 ◽  
Nestin Expression ◽  
The Difference ◽  
Nevus Sebaceous ◽  
Sensitive Marker

Background. Trichoblastoma (TB) and basal cell carcinoma (BCC) are 2 different neoplasms composed of basaloid cells and have overlapping histopathological features. We compared the immunoexpression of CD10, T-cell death-associated gene 51 (TDAG51), cytokeratin 20 (CK20), androgen receptor (AR), insulinoma-associated protein 1 (INSM1), and nestin for the differential diagnosis of these tumors. Materials and Methods. We assessed a total of 27 BCC and 27 TB cases, including 4 TB lesions in nevus sebaceous and 3 malignant TB lesions for CD10, TDAG51, CK20, AR, INSM1, and nestin expression. Results. Staining for CK20, TDAG51, INSM1, and stromal CD10 was significantly more common in TB cases than in BCC cases ( P < .001). Epithelial CD10 and AR staining was significantly more common in BCC cases than in TB cases ( P < .001). The difference between the groups for nestin staining was not significant ( P > .05). Stromal CD10 staining was the most sensitive marker (96.3%) and INSM1 the least sensitive (55.6%) marker for TB. TDAG51 showed 100% specificity for TB. A larger number of CK20 positive cells was found in the cases associated with nevus sebaceous than in the other TBs. Conclusion. All the selected markers except nestin were useful for the differential diagnosis between TB and BCC. CD10 and TDAG51 were more useful than the other markers. The use of CK20 could be preferred in nevus sebaceous lesions. INSM1 was less effective in highlighting Merkel cells within the lesion than CK20.

Bcl-2 and CD10 expression in the differential diagnosis of trichoblastoma, basal cell carcinoma, and basal cell carcinoma with follicular differentiation

2009 ◽  
Vol 48 (7) ◽  
pp. 713-717 ◽  
Author(s):  
Alicia Córdoba ◽  
David Guerrero ◽  
Begoña Larrinaga ◽  
Maria Eugenia Iglesias ◽  
Maria Asunción Arrechea ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cd10 Expression

scholarly journals Differences in age and topographic distribution of the different histological subtypes of basal cell carcinoma, Taubaté (SP), Brazil

2013 ◽  
Vol 88 (5) ◽  
pp. 726-730 ◽  
Author(s):  
Flavia Regina Ferreira ◽  
Bruna da Costa Pevide ◽  
Rafaela Fabri Rodrigues ◽  
Luiz Fernando Costa Nascimento ◽  
Marcia Lanzoni de Alvarenga Lira
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Color ◽  
Age Of Onset ◽  
The Body ◽  
University Hospital ◽  
Histological Subtype ◽  
Histological Subtypes ◽  
The Mean

BACKGROUND: Basal cell carcinoma is the most common form of cancer in humans. OBJECTIVES: To identify the epidemiology of basal cell carcinoma in Taubaté-SP and verify a possible association between topography and the different histological subtypes of this tumor. METHODS: This was a cross-sectional study conducted at The University Hospital of Taubaté between 01/01/08 and 12/31/09. The study included patients with a confirmed diagnosis of basal cell carcinoma, of both genders, without age restrictions. The variables studied were incidence of basal cell carcinoma, topography, histological subtype, skin color, age and gender. We employed the chi-square test to identify the association between histological subtype and topography, and the student's t test to compare the mean age of onset for the different histological subtypes. RESULTS: The study included 239 individuals. The mean age of the sample was 68.0 years. Male subjects (57.7%) and whites (87.1%) predominated in the study. The predominant histological subtype was nodular (34.7%), followed by the superficial subtype. The most frequent sites of involvement were the head and neck (areas exposed to light), with predominance of the nasal region. The superficial subtype was an exception, as it showed a strong association with unexposed areas like the trunk. The mean age of onset of superficial basal cell carcinoma also differed from that of the other histological subtypes, 63.0 and 69.0 years, respectively. CONCLUSION: The results of this study suggest an association of the superficial histological subtype with younger patients and unexposed areas of the body, linking this type of tumor with a pattern of intermittent sun exposure, more similar to the standard photocarcinogenesis of melanoma.

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