scholarly journals A Histologic and Immunocytochemical Study of Choroid Plexus Tumors of the Dog

1989 ◽  
Vol 26 (1) ◽  
pp. 55-64 ◽  
Author(s):  
J. L. Ribas ◽  
H. Mena ◽  
K. G. Braund ◽  
I. A. Sesterhenn ◽  
M. Toivio-Kinnucan
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Brain Parenchyma ◽  
Nuclear Atypia ◽  
Cellular Density ◽  
Microscopic Field ◽  
Mitotic Figures ◽  
Immunohistochemical Studies ◽  
The Brain ◽  
Plexus Papilloma

Sixteen choroid plexus (CP) tumors in 12 male and four female adult dogs were analyzed microscopically. Tumors were in the lateral (six), third (six), and fourth (four) ventricles. The average age of the dogs was 6 years. Tumors were classified by the following criteria: 1) choroid plexus papilloma (CPP), which resembled normal choroid plexus and had low mitotic activity; 2) choroid plexus papilloma with atypical features (atypical CPP), which had increased cellular density, nuclear atypia, two to four mitoses per 40 × microscopic field, necrosis, and infiltration of the brain parenchyma and/or leptomeninges; and 3) choroid plexus carcinoma (CPC), which had marked nuclear atypia, poorly formed papillae, >four mitoses per 40 × microscopic field, abnormal mitotic figures, and/or extraneural metastasis. The 16 tumors were classified either as CPP or atypical CPP (none as CPC). Statistically significant associations between brain infiltration and necrosis and atypical CPP were identified. Immunohistochemical studies in 11 tumors demonstrated staining for keratin in three tumors, two of which also reacted with carcinoembryonic antigen (CEA). There was no immunoreactivity with glial fibrillary acidic protein or epithelial membrane antigen. Choroid plexus from one of three control dogs stained focally for cytokeratin only. It is concluded that normal choroid plexus and CP tumors in the dog express epithelial, but not glial differentiation.

scholarly journals Choroid plexus papilloma and Aicardi syndrome: case report

2002 ◽  
Vol 60 (4) ◽  
pp. 1008-1010 ◽  
Author(s):  
Geraldo Pianetti Filho ◽  
Luiz Fernando Fonseca ◽  
Márcia Cristina da Silva
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Imaging Studies ◽  
Baby Girl ◽  
The Third ◽  
Aicardi Syndrome ◽  
The Brain ◽  
Plexus Papilloma

A case of Aicardi syndrome associated with a choroid plexus papilloma of the third and both lateral ventricles in a 15 months old baby girl is repported. The tumor was completely removed via three craniotomies. Reports of the literature with the association of choroid plexus papilloma and Aicardi syndrome are rare. We suggest that children diagnosed with Aicardi syndrome should routinely undergo imaging studies of the brain, such as computed tomography or magnetic resonance.

scholarly journals Choroid plexus papilloma in an adult ewe – a case report

2013 ◽  
Vol 82 (1) ◽  
pp. 9-11
Author(s):  
Jose María González ◽  
Delia Lacasta ◽  
Santiago Sanz ◽  
María Climent ◽  
Alicia Uixera ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Small Ruminant ◽  
Choroid Plexus Papilloma ◽  
Postural Reactions ◽  
The Central Nervous System ◽  
Primary Neoplasms ◽  
The Right ◽  
Veterinary Faculty ◽  
The Brain ◽  
Plexus Papilloma

Primary neoplasms of the central nervous system have been rarely reported in sheep. A three-year-old Rasa Aragonesa ewe was admitted to the small ruminant external consultancy at the Veterinary Faculty of University of Zaragoza, Spain. Clinical, haematological and neurological examinations were performed. Neurological examination showed signs of ataxia, hyperextension of the right front limb and abnormal postural reactions. The animal was unable to stand and walk, even with help. Patellar and flexor reflexes were normal and superficial sensation was present but decreased. Humanitarian sacrifice was carried out one month later. Gross and histopathological findings revealed a choroid plexus papilloma located in the fourth ventricle of the brain. To the authors’ knowledge this is the first description of this neoplastic disorder in sheep.

scholarly journals Posterior interhemispheric approach for surgical removal of a choroid plexus papilloma in the ventricular atrium.

2020 ◽  
Vol 3 (1(January-April)) ◽  
pp. e632020
Author(s):  
Marcos Rodrigo Pereira Eismann ◽  
Antônio Cesar De Mello Mussi
Keyword(s):  
Choroid Plexus ◽  
Benign Tumor ◽  
Choroid Plexus Papilloma ◽  
Surgical Removal ◽  
Small Lesion ◽  
Resonance Imaging ◽  
Interhemispheric Approach ◽  
The Right ◽  
The Brain ◽  
Plexus Papilloma

A 12 year-old boy with headaches for 2 months. Magnetic resonance imaging of the brain found a small lesion in the atrium of the right lateral ventricle. We show a posterior interhemispheric approach to the ventricular atrium through a corticotomy in the pre-cuneus and the posterior cingulate gyrus. This approach has the advantage of avoiding lesion to the optic radiation. A complete resection of the lesion was performed without complications. Anatomopathological result showed choroid plexus papilloma. This benign tumor corresponds to less than 1% of brain tumors and typically presents with signs of intracranial hypertension with hydrocephalus.

MR Findings of Choroid Plexus Papilloma: Case Report

1994 ◽  
Vol 30 (4) ◽  
pp. 643
Author(s):  
Joo Hyeong Oh ◽  
Tae Hoon Kim ◽  
Woo Suk Choi
Keyword(s):  
Case Report ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Plexus Papilloma

Spinal deposits of a benign choroid plexus papilloma

2008 ◽  
Vol 15 (6) ◽  
pp. 708-712 ◽  
Author(s):  
H. Akil ◽  
N.J. Coupe ◽  
J. Singh
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Plexus Papilloma

Embolization of a giant hypervascularized choroid plexus papilloma with onyx by direct puncture: a case report

2015 ◽  
Vol 32 (4) ◽  
pp. 717-721 ◽  
Author(s):  
Gustavo S. Jung ◽  
Leonardo G. Ruschel ◽  
Andre G. Leal ◽  
Ricardo Ramina
Keyword(s):  
Case Report ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Direct Puncture ◽  
Plexus Papilloma

Choroid plexus papilloma of the third ventricle

Neurosurgery ◽  
1983 ◽  
Vol 12 (2) ◽  
pp. 217???20 ◽  
Author(s):  
W C Gradin ◽  
C Taylon ◽  
A H Fruin
Keyword(s):  
Choroid Plexus ◽  
Third Ventricle ◽  
Choroid Plexus Papilloma ◽  
The Third ◽  
Plexus Papilloma

IMMUNOHISTOCHEMICAL STUDIES OF BLOOD BRAIN BARRIER AFTER ADMINISTRATION OF ABHRAK BHASM IN WISTAR RATS

2021 ◽  
pp. 13-19
Author(s):  
Amita Singh ◽  
Raj Kumar ◽  
S. K. Kannaujia ◽  
Manikrishna Manikrishna ◽  
N. P. Singh
Keyword(s):  
Blood Brain Barrier ◽  
Wistar Rats ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Major Constituent ◽  
Control Group ◽  
Blood Brain ◽  
Biological Studies ◽  
Immunohistochemical Studies ◽  
The Brain

Abhrak bhasma (AB) is a type of bhasma prepared from repeated incineration of mineral mica with decoctions of about 72 herbs. The particle size of Abhrak bhasm has been shown to be in the range of 29-88 nanometers and Fe, Ca, Si, Mg and K are found to be as major constituent. Many drugs developed to treat Central Nervous System (CNS) disorders are unable to reach the brain parenchyma in therapeutically relevant concentrations. The blood brain barrier protects brain parenchyma from the uctuation of plasma composition, from pathogenic agents and maintains homeostasis of the brain parenchyma by restricting non-specic ux of ions, peptides, proteins and even cells into and out the brain. Immunohistochemistry is being widely employed as a tool for biological studies. This study is conducted to examine the change in the continuity of Blood brain barrier by using immunohistochemistry, once Abhrak bhasm drug is given in experimental animal and also to examine the histology of organs. In this study a total of 30 adult albino Wistar rats of approximately 4 months age (approx. 150-200 gms) of either sex selected randomly to see the effect of Abhrak bhasm, an ayurvedic drug on Wistar rats. The rats were weighed, marked and divided into 5 groups each consisting of six animals. In normal control group (Group E), no drug was administered and in rest of the four treated groups (Group-A,B,C,D), Abhrak bhasm @ 36 mg/kg B.wt. was administered orally once in each rat. Brain, liver, kidneys,spleen and blood samples were collected in 10% formalin solution after euthanizing the rats at 0.5,2,6 & 12 hours of Abhrak bhasma drug intervention. The alterations in any of the biochemical parameters are within the tolerable limits of liver and kidney since the dose of abhrak bhasm did not affect liver and kidneys. In the present study, the increase in ALP level may be the result of alterations in metabolisms that occurred without any signicant alteration in histology of liver. After applying the immunohistochemistry with the research markers GFAP, CD 34, S 100, GLUT-1 and RECA-1 on the rats in groups A,B,C and D, there was no change in the intensity of immunohistochemistry, with respect to control. While on applying the Occludin, the intensity of immunohistochemistry was reduced in all the treatment groups as compared to the control group. On the basis of ndings of present study it can be concluded that the therapeutic dose of Abhrak bhasma causes changes at the level of tight junctions present in blood brain barrier in rats which is shown by immunohistochemistry with occludin research marker. There is no toxic effect of drug on different organs of rats as no signicant changes in histology of organs are seen. More studies need to be done to check the permeability of blood brain barrier for Abhrak bhasma drug, like calculating its concentration in brain tissues and other vital organs of rat.

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