scholarly journals Prognosis of Canine Mast Cell Tumors: A Comparison of Three Methods

1994 ◽  
Vol 31 (6) ◽  
pp. 637-647 ◽  
Author(s):  
J. P. C. Simoes ◽  
P. Schoning ◽  
M. Butine
Keyword(s):  
Mast Cell ◽  
Prognostic Factors ◽  
Prognostic Index ◽  
Nucleolar Organizer ◽  
Nuclear Antigen ◽  
Nucleolar Organizer Regions ◽  
Histologic Grading ◽  
Mast Cell Tumors ◽  
Time Period ◽  
Grade 3

In this study, age, sex, recurrence, metastasis, death rate, and histologic patterns were in agreement with those of previous reports on canine mast cell tumors. Histologic grading, mitotic index, chromosome nucleolar organizer regions stained with silver (AgNORs), and anti-proliferating cell nuclear antigen (PCNA) were evaluated as indicators of prognosis. Histologic grading, AgNORs estimated in 100 cells, and PCNA-labeled fraction estimated in five high power fields (HPFs) were significantly different between recurring and nonrecurring tumors. Those prognostic factors were also significantly different between tumors that metastasized and those that did not. The survival time was lower in dogs with mast cell tumors with histologic grade 3 (Patnaik's), AgNOR counts higher than 2.25, and PCNA count in five HPFs higher than 261. The significance of these factors as markers for prognosis determined by logistic regression analysis differed with the time period considered. By combining the three most significant prognostic factors in a prognostic index, three models were obtained to determine the probability of nonrecurrence at 3, 6, and 9 months after surgery. The models were accurate in the prediction of the outcome of up to 80% of mast cell tumors. The use of these models provides a less subjective means of prognosticating mast cell tumors than the use of any one component alone.

Prognostic Indicators and Clinical Outcome in Dogs with Subcutaneous Mast Cell Tumors Treated with Surgery Alone: 43 Cases

2020 ◽  
Vol 56 (4) ◽  
pp. 215-225 ◽  
Author(s):  
Virginia Gill ◽  
Nicole Leibman ◽  
Sebastien Monette ◽  
Diane M. Craft ◽  
Philip J. Bergman
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Grading System ◽  
Nucleolar Organizer Regions ◽  
Low Grade ◽  
Mast Cell Tumors ◽  
Proliferating Cell

ABSTRACT The purpose of this study was to determine if clinical findings, histologic grade, or other histologic features were associated with clinical outcome in dogs with subcutaneous mast cell tumors (MCTs). Medical records of 43 client-owned dogs were retrospectively reviewed, and follow-up information was gathered via phone or follow-up examination. Progression-free survival (PFS), disease-free interval (DFI), and overall survival were calculated. Forty-two and twenty-two dogs, respectively, had grade 2 (Patnaik grading system) or low-grade tumors (two-tier grading system). Median PFS was 1474 days. Median DFI was not reached at >1968 days. Overall median survival time was not reached at >1968 days. In univariate analysis, argyrophilic nucleolar organizer regions (AgNORs), proliferating cell nuclear antigen, and mitotic index were negatively prognostic for PFS whereas Ki-67, proliferating cell nuclear antigen, and microvessel density were negatively prognostic for DFI. In multivariate analysis, AgNORs remained negatively prognostic for PFS. Results suggest that proliferation indices, especially AgNORs, may be useful in predicting the rare poor outcomes in dogs with subcutaneous MCTs. The vast majority of subcutaneous MCTs appear to be low or intermediate grade with excellent outcomes from good local tumor control.

Correlation of histologic grading of canine mast cell tumors with Ki67/PCNA/AgNOR/c-Kit scores: 38 cases (2002-2003)

2004 ◽  
Vol 2 (2) ◽  
pp. 98-98 ◽  
Author(s):  
P. J. Bergman ◽  
D. M. Craft ◽  
S. J. Newman ◽  
K. Baer ◽  
M. A. Camps-Palau ◽  
...  
Keyword(s):  
Mast Cell ◽  
Histologic Grading ◽  
Mast Cell Tumors

Biologic Behavior and Prognostic Factors for Mast Cell Tumors of the Canine Muzzle: 24 Cases (1990-2001)

2003 ◽  
Vol 17 (5) ◽  
pp. 687 ◽  
Author(s):  
Tracy L. Gieger ◽  
Alain P. Théon ◽  
Jonathan A. Werner ◽  
Margaret C. McEntee ◽  
Kenneth M. Rassnick ◽  
...  
Keyword(s):  
Mast Cell ◽  
Prognostic Factors ◽  
Mast Cell Tumors

Chirurgie subkutaner Mastzelltumoren beim Hund: Prognosefaktoren und Outcome

2021 ◽  
Vol 49 (03) ◽  
pp. 228-228
Author(s):  
Daniela Simon Betz
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostische Faktoren ◽  
Microvascular Density ◽  
Nuclear Antigen ◽  
Prognostic Indicators ◽  
Ki 67 ◽  
Mast Cell Tumors ◽  
Proliferating Cell

Gill V, Leibman N, Monette S et al. Prognostic Indicators and Clinical Outcome in Dogs with Subcutaneous Mast Cell Tumors. J Am Anim Hosp Assoc 2020; 56 (4): 215–225 Mastzelltumoren (MZT) sind häufige kutane Neoplasien beim Hund, für die verschiedene prognostische Faktoren beschrieben wurden. Zu diesen zählen der histologische Grad nach Patnaik (3 Grade) oder Kiupel (2 Grade) sowie einige Marker zellulärer Differenzierung wie AgNORs (agyrophylic nuclear organizer regions), Ki-67 oder PCNA (proliferating cell nuclear antigen). Weitere prognostisch aussagekräftige Parameter sind der c-Kit-Mutationsstatus, die mikrovaskuläre Dichte (microvascular density, MVD) und der mitotische Index (MI). Ziel der Studie war, den klinischen Verlauf nach operativer Entfernung subkutaner MZT beim Hund auszuwerten und die Wertigkeit der verschiedenen Prognosefaktoren zu validieren.

Sign in / Sign up

Export Citation Format

Share Document