Chirurgie subkutaner Mastzelltumoren beim Hund: Prognosefaktoren und Outcome

2021 ◽  
Vol 49 (03) ◽  
pp. 228-228
Author(s):  
Daniela Simon Betz
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostische Faktoren ◽  
Microvascular Density ◽  
Nuclear Antigen ◽  
Prognostic Indicators ◽  
Ki 67 ◽  
Mast Cell Tumors ◽  
Proliferating Cell

Gill V, Leibman N, Monette S et al. Prognostic Indicators and Clinical Outcome in Dogs with Subcutaneous Mast Cell Tumors. J Am Anim Hosp Assoc 2020; 56 (4): 215–225 Mastzelltumoren (MZT) sind häufige kutane Neoplasien beim Hund, für die verschiedene prognostische Faktoren beschrieben wurden. Zu diesen zählen der histologische Grad nach Patnaik (3 Grade) oder Kiupel (2 Grade) sowie einige Marker zellulärer Differenzierung wie AgNORs (agyrophylic nuclear organizer regions), Ki-67 oder PCNA (proliferating cell nuclear antigen). Weitere prognostisch aussagekräftige Parameter sind der c-Kit-Mutationsstatus, die mikrovaskuläre Dichte (microvascular density, MVD) und der mitotische Index (MI). Ziel der Studie war, den klinischen Verlauf nach operativer Entfernung subkutaner MZT beim Hund auszuwerten und die Wertigkeit der verschiedenen Prognosefaktoren zu validieren.

Prognostic Indicators and Clinical Outcome in Dogs with Subcutaneous Mast Cell Tumors Treated with Surgery Alone: 43 Cases

2020 ◽  
Vol 56 (4) ◽  
pp. 215-225 ◽  
Author(s):  
Virginia Gill ◽  
Nicole Leibman ◽  
Sebastien Monette ◽  
Diane M. Craft ◽  
Philip J. Bergman
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Grading System ◽  
Nucleolar Organizer Regions ◽  
Low Grade ◽  
Mast Cell Tumors ◽  
Proliferating Cell

ABSTRACT The purpose of this study was to determine if clinical findings, histologic grade, or other histologic features were associated with clinical outcome in dogs with subcutaneous mast cell tumors (MCTs). Medical records of 43 client-owned dogs were retrospectively reviewed, and follow-up information was gathered via phone or follow-up examination. Progression-free survival (PFS), disease-free interval (DFI), and overall survival were calculated. Forty-two and twenty-two dogs, respectively, had grade 2 (Patnaik grading system) or low-grade tumors (two-tier grading system). Median PFS was 1474 days. Median DFI was not reached at >1968 days. Overall median survival time was not reached at >1968 days. In univariate analysis, argyrophilic nucleolar organizer regions (AgNORs), proliferating cell nuclear antigen, and mitotic index were negatively prognostic for PFS whereas Ki-67, proliferating cell nuclear antigen, and microvessel density were negatively prognostic for DFI. In multivariate analysis, AgNORs remained negatively prognostic for PFS. Results suggest that proliferation indices, especially AgNORs, may be useful in predicting the rare poor outcomes in dogs with subcutaneous MCTs. The vast majority of subcutaneous MCTs appear to be low or intermediate grade with excellent outcomes from good local tumor control.

Comparison of immunostainings for proliferating cell nuclear antigen and Ki-67 in human extraocular lesions

1997 ◽  
Vol 235 (12) ◽  
pp. 767-772 ◽  
Author(s):  
Tatsuo Kodama ◽  
Katsue Kawamoto ◽  
Tatsuro Kono ◽  
Yuzo Shibuya ◽  
Tomoichi Setogawa
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Ki 67 ◽  
Proliferating Cell

Clinical relevance of p53 index and expression of proliferating cell nuclear antigen and Ki-67 in gastric cancer

1998 ◽  
Vol 124 (9) ◽  
pp. 497-502 ◽  
Author(s):  
Leena Setälä ◽  
Veli-Matti Kosma ◽  
Pertti Lipponen ◽  
Anita Naukkarinen ◽  
Stig Nordling ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Proliferating Cell Nuclear Antigen ◽  
Clinical Relevance ◽  
Nuclear Antigen ◽  
Ki 67 ◽  
Proliferating Cell

Proliferating cell nuclear antigen in prostatic adenocarcinoma: Correlation with established prognostic indicators

Urology ◽  
1994 ◽  
Vol 43 (5) ◽  
pp. 660-666 ◽  
Author(s):  
Susan E. Spires ◽  
C. Darrell Jennings ◽  
Evelyn R. Banks ◽  
David P. Wood ◽  
Diane D. Davey ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Prostatic Adenocarcinoma ◽  
Nuclear Antigen ◽  
Prognostic Indicators ◽  
Proliferating Cell
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