The Relationship between Inflammatory Markers, Leptin and Adiponectin in Chronic Hemodialysis Patients

2004 ◽  
Vol 27 (10) ◽  
pp. 835-841 ◽  
Author(s):  
C-T. Lee ◽  
C-H. Lee ◽  
Y. Su ◽  
Y-C. Chuang ◽  
T-L. Tsai ◽  
...  
2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Naoko Otani-Takei ◽  
Takahiro Masuda ◽  
Tetsu Akimoto ◽  
Sumiko Honma ◽  
Yuko Watanabe ◽  
...  

Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of theKlothogene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of6.7±5.4years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309–449). Patients with serum soluble Klotho levels below the lower quartile (<309 pg/mL) had significantly higher cardiovascular and all-cause mortality rates. Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29–13.48). We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality.


2008 ◽  
Vol 40 (3) ◽  
pp. 793-799 ◽  
Author(s):  
Seyhun Kursat ◽  
Hulya Bahadir Colak ◽  
Aysun Toraman ◽  
Cenk Ekmekci ◽  
Hikmet Tekce ◽  
...  

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Imane Failal ◽  
Sanae Ezzaki ◽  
Marouane Sayeh ◽  
Salma Elkhayat ◽  
Ghizlaine Medkouri ◽  
...  

Abstract Background and Aims Physical activity is often reduced in chronic hemodialysis patients. Studies having evaluated hemodialysis reveal a significant sedentary lifestyle. which is associated with excess mortality. Conversely, the benefits in terms of morbidity and mortality from physical activity are numerous. The fight against sedentary lifestyles in hemodialysis patients must be one of the objectives of healthcare teams. For this reason, our study aims to assess physical inactivity using a physical activity score from DIJON in chronic hemodialysis patients and to identify the factors linked to a decrease in physical activity in them and to propose programs aimed at to encourage PA as well as exercises adapted to the hemodialysis patient. Method This is a descriptive and analytical cross-sectional study conducted during the month of January 2020, in the nephrology and hemodialysis department of CHU IBN ROCHD. We used the Dijon questionnaire translated into Arabic to measure the PA taking into account daily, sports or leisure activities. The PA level benchmarks are 0–10 (low), 10–20 (medium), and 20–30 (high). Results Our study included 71 patients. The average age was 46.5 years with extremes ranging from 16 to 93 years, there is a slight male predominance with a sex ratio of 1.1. Initial nephropathy was undetermined nephropathy in 53.5%, glomerular in 29.5%, diabetic in 7% and hypertensive in 1.4%. The age of the periodic hemodialysis treatment in our patients varied from 1 month to 44 years, with an average duration of 17.3 years. 91.5% of patients had an arteriovenous fistula as a vascular approach, 8.4% of patients were dialyzed on a catheter. The overall level of physical activity was high only in 4.5% of patients, while it was low in 61.3% and moderate in 34% of patients. The study of the relationship between the decrease in physical activity and different demographic, clinical and paraclinical parameters had revealed that the decrease in physical activity was significantly correlated with seniority on hemodialysis, gender, l he advanced age, the different degrees of anemia, and the cardiovascular affections, on the other hand no significant correlation was found between the decrease in physical activity and hypocalcemia, hyperphosphatemia, and hyperparathyroidism. Conclusion Our results show that the level of physical activity is linked to many parameters, some of which can be modified. Prescribing an adapted and personalized program would improve the prognosis related to co-morbidities and the quality of life of our patients.


2010 ◽  
Vol 43 (4) ◽  
pp. 1179-1186 ◽  
Author(s):  
Diana Moldovan ◽  
Ioan Moldovan ◽  
Crina Rusu ◽  
Simona Racasan ◽  
Ioan M. Patiu ◽  
...  

1987 ◽  
Vol 20 (4) ◽  
pp. 323-327
Author(s):  
Shinichi Hosokawa ◽  
Hiroshi Nishitani ◽  
Tadao Tomoyoshi ◽  
Kenji Sawanishi ◽  
Osamu Yoshida

1999 ◽  
Vol 14 (5) ◽  
pp. 546 ◽  
Author(s):  
Ja Ryong Koo ◽  
Ky Yong Pak ◽  
Ken Ho Kim ◽  
Rho Won Chun ◽  
Hyung Jik Kim ◽  
...  

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