Status of First-Episode Psychosis Patients Presenting for Routine Care in a Defined Catchment Area

AbstractBackgroundDiscrepancies between population-based estimates of the incidence of psychotic disorder and the treated incidence reported by early psychosis intervention (EPI) programs suggest additional cases may be receiving services elsewhere in the health system. Our objective was to estimate the incidence of non-affective psychotic disorder in the catchment area of an EPI program, and compare this to EPI-treated incidence estimates.MethodsWe constructed a retrospective cohort (1997–2015) of incident cases of non-affective psychosis aged 16–50 years in an EPI program catchment using population-based linked health administrative data. Cases were identified by either one hospitalization or two outpatient physician billings within a 12-month period with a diagnosis of non-affective psychosis. We estimated the cumulative incidence and EPI-treated incidence of non-affective psychosis using denominator data from the census. We also estimated the incidence of first-episode psychosis (people who would meet the case definition for an EPI program) using a novel approach.ResultsOur case definition identified 3245 cases of incident non-affective psychosis over the 17-year period. We estimate that the incidence of first-episode non-affective psychosis in the program catchment area is 33.3 per 100 000 per year (95% CI 31.4–35.1), which is more than twice as high as the EPI-treated incidence of 18.8 per 100 000 per year (95% CI 17.4–20.3).ConclusionsCase ascertainment strategies limited to specialized psychiatric services may substantially underestimate the incidence of non-affective psychotic disorders, relative to population-based estimates. Accurate information on the epidemiology of first-episode psychosis will enable us to more effectively resource EPI services and evaluate their coverage.

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T131. INCIDENCE OF FIRST-EPISODE PSYCHOSIS IN THE CATCHMENT AREA OF RIBEIRÃO PRETO, BRAZIL

Schizophrenia Bulletin ◽

10.1093/schbul/sby016.407 ◽

2018 ◽

Vol 44 (suppl_1) ◽

pp. S166-S166

Author(s):

Cristina Del-Ben ◽

Shuhama Rosana ◽

Camila Loureiro ◽

Taciana Ragazzi ◽

Daniela Zanatta ◽

...

Keyword(s):

Catchment Area ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis

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The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

10.21203/rs.2.20997/v1 ◽

2020 ◽

Author(s):

Tiziano De Matteis ◽

Giuseppe D'Andrea ◽

Jatin Lal ◽

Domenico Berardi ◽

Ilaria Tarricone

Keyword(s):

Incidence Study ◽

Catchment Area ◽

Maternal Education ◽

Health Centre ◽

First Episode Psychosis ◽

First Episode ◽

Environment Interaction ◽

Episode Psychosis ◽

Study Results ◽

The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

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Early intervention in psychosis in emerging countries: Findings from a first‐episode psychosis programme in the Ribeirão Preto catchment area, southeastern Brazil

Early Intervention in Psychiatry ◽

10.1111/eip.13252 ◽

2021 ◽

Author(s):

Gabriel Elias Corrêa‐Oliveira ◽

Luis Felipe Scarabelot ◽

Jéssica Morais Araújo ◽

André Campiolo Boin ◽

Rebeca Mendes de Paula Pessoa ◽

...

Keyword(s):

Early Intervention ◽

Catchment Area ◽

First Episode Psychosis ◽

Emerging Countries ◽

Southeastern Brazil ◽

First Episode ◽

Episode Psychosis ◽

Early Intervention In Psychosis

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Initial treatment phase in early psychosis: can intensive home treatment prevent admission?

Psychiatric Bulletin ◽

10.1192/pb.30.7.243 ◽

2006 ◽

Vol 30 (7) ◽

pp. 243-246 ◽

Cited By ~ 5

Author(s):

Matthew Gould ◽

Kate Theodore ◽

Stephen Pilling ◽

Paul Bebbington ◽

Mark Hinton ◽

...

Keyword(s):

Initial Treatment ◽

Catchment Area ◽

Admission Rate ◽

Treatment Phase ◽

First Episode Psychosis ◽

First Episode ◽

Clinical Implications ◽

Crisis Resolution ◽

Crisis Resolution Teams ◽

Episode Psychosis

Aims and MethodThe aim of this study was to describe the early treatment phase in first-episode psychosis in an area with well-established crisis resolution teams. Socio-demographic characteristics and patterns of initial treatment were investigated for all individuals with first-episode psychosis identified prospectively over a 1-year period in two London boroughs.ResultsOver a year, 111 people presented with first-episode psychosis. Fifty-one people (46%) were initially managed in the community, with the remaining 60 (54%) admitted to in-patient units immediately. By 3 months after presentation, a total of 80 people (72%) had been admitted and 54 (49%) had been compulsorily detained under the Mental Health Act 1983. Thirty-three people were initially managed by the crisis resolution teams and 15 of these were eventually admitted.Clinical ImplicationsIn a catchment area in which alternatives to admission are well developed, the admission rate for first-episode psychosis was still high.

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Poster #T217 PRELIMINARY SAMPLE DESCRIPTION OF FIRST EPISODE PSYCHOSIS IN A BRAZILIAN LARGE CATCHMENT AREA

Schizophrenia Research ◽

10.1016/s0920-9964(14)71033-3 ◽

2014 ◽

Vol 153 ◽

pp. S366

Author(s):

Rosana Shuhama ◽

Silvia Tenan ◽

Juliana Souza ◽

Maristela S. Schaufelberger ◽

Paulo Louzada-Junior ◽

...

Keyword(s):

Catchment Area ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

Large Catchment

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Preventing antipsychotic-induced weight gain in first-episode psychosis: Transitioning dietitians into routine care

Nutrition & Dietetics ◽

10.1111/1747-0080.12211 ◽

2015 ◽

Vol 73 (3) ◽

pp. 303-304 ◽

Cited By ~ 2

Author(s):

Scott B. Teasdale ◽

Simon Rosenbaum ◽

Andrew Watkins ◽

Jackie Curtis ◽

Megan Kalucy ◽

...

Keyword(s):

Weight Gain ◽

Routine Care ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis

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The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

10.21203/rs.2.20997/v2 ◽

2020 ◽

Author(s):

Tiziano De Matteis ◽

Giuseppe D'Andrea ◽

Jatin Lal ◽

Domenico Berardi ◽

Ilaria Tarricone

Keyword(s):

Incidence Study ◽

Catchment Area ◽

Maternal Education ◽

Health Centre ◽

First Episode Psychosis ◽

First Episode ◽

Environment Interaction ◽

Episode Psychosis ◽

Study Results ◽

The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

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The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

10.21203/rs.2.20997/v3 ◽

2020 ◽

Author(s):

Tiziano De Matteis ◽

Giuseppe D'Andrea ◽

Jatin Lal ◽

Domenico Berardi ◽

Ilaria Tarricone

Keyword(s):

Incidence Study ◽

Catchment Area ◽

Maternal Education ◽

Health Centre ◽

First Episode Psychosis ◽

First Episode ◽

Environment Interaction ◽

Episode Psychosis ◽

Study Results ◽

The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

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