scholarly journals The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

2020 ◽  
Author(s):  
Tiziano De Matteis ◽  
Giuseppe D'Andrea ◽  
Jatin Lal ◽  
Domenico Berardi ◽  
Ilaria Tarricone
Keyword(s):  
Incidence Study ◽  
Catchment Area ◽  
Maternal Education ◽  
Health Centre ◽  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Episode Psychosis ◽  
Study Results ◽  
The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

scholarly journals The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

2020 ◽  
Author(s):  
Tiziano De Matteis ◽  
Giuseppe D'Andrea ◽  
Jatin Lal ◽  
Domenico Berardi ◽  
Ilaria Tarricone
Keyword(s):  
Incidence Study ◽  
Catchment Area ◽  
Maternal Education ◽  
Health Centre ◽  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Episode Psychosis ◽  
Study Results ◽  
The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

scholarly journals The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

2020 ◽  
Author(s):  
Tiziano De Matteis ◽  
Giuseppe D'Andrea ◽  
Jatin Lal ◽  
Domenico Berardi ◽  
Ilaria Tarricone
Keyword(s):  
Incidence Study ◽  
Catchment Area ◽  
Maternal Education ◽  
Health Centre ◽  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Episode Psychosis ◽  
Study Results ◽  
The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

Brief psycho-education for caregivers of persons with first episode psychosis

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Praful Prabhuappa Kapse ◽  
Manisha Kiran
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Control Group ◽  
Episode Psychosis ◽  
Study Results ◽  
Before And After ◽  
Quasi Experimental ◽  
Expressed Emotions ◽  
Experimental Group ◽  
Group Family

Caring for the persons with first episode psychosis is challenging and demanding. It may lead to the increased burden, expressed emotions among the caregivers. The numerous studies have shown that high burden and negative expressed emotions among caregivers can lead to early relapse in the patients with first episode psychosis. To evaluate the effects of the brief psychoeducation on the caregivers burden and expressed emotions. A quasi experimental - before and after with control group research design was adopted for the study. A total of 60 caregivers have participated in the study, of which 30 caregivers in experimental group and 30 caregivers in the control group. Family Burden Interview Schedule (Pai and Kapoor, 1981) and Attitude Questionnaire (Sethi et al., 1981) was used to assess caregiver's burden and expressed emotions. At end of the psychoeducation intervention, burden among caregivers and negative expressed emotions of the caregivers have significantly reduced. The positive expressed emotions have been increased. Study results demonstrates the importance of psychoeducation intervention in reducing the burden and negative expressed emotions.

Estimating the incidence of first-episode psychosis using population-based health administrative data to inform early psychosis intervention services

2018 ◽  
Vol 49 (12) ◽  
pp. 2091-2099 ◽  
Author(s):  
Kelly K. Anderson ◽  
Ross Norman ◽  
Arlene G. MacDougall ◽  
Jordan Edwards ◽  
Lena Palaniyappan ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Administrative Data ◽  
Catchment Area ◽  
Population Based ◽  
First Episode Psychosis ◽  
Case Definition ◽  
First Episode ◽  
Affective Psychosis ◽  
Health Administrative Data ◽  
Episode Psychosis

AbstractBackgroundDiscrepancies between population-based estimates of the incidence of psychotic disorder and the treated incidence reported by early psychosis intervention (EPI) programs suggest additional cases may be receiving services elsewhere in the health system. Our objective was to estimate the incidence of non-affective psychotic disorder in the catchment area of an EPI program, and compare this to EPI-treated incidence estimates.MethodsWe constructed a retrospective cohort (1997–2015) of incident cases of non-affective psychosis aged 16–50 years in an EPI program catchment using population-based linked health administrative data. Cases were identified by either one hospitalization or two outpatient physician billings within a 12-month period with a diagnosis of non-affective psychosis. We estimated the cumulative incidence and EPI-treated incidence of non-affective psychosis using denominator data from the census. We also estimated the incidence of first-episode psychosis (people who would meet the case definition for an EPI program) using a novel approach.ResultsOur case definition identified 3245 cases of incident non-affective psychosis over the 17-year period. We estimate that the incidence of first-episode non-affective psychosis in the program catchment area is 33.3 per 100 000 per year (95% CI 31.4–35.1), which is more than twice as high as the EPI-treated incidence of 18.8 per 100 000 per year (95% CI 17.4–20.3).ConclusionsCase ascertainment strategies limited to specialized psychiatric services may substantially underestimate the incidence of non-affective psychotic disorders, relative to population-based estimates. Accurate information on the epidemiology of first-episode psychosis will enable us to more effectively resource EPI services and evaluate their coverage.

scholarly journals T131. INCIDENCE OF FIRST-EPISODE PSYCHOSIS IN THE CATCHMENT AREA OF RIBEIRÃO PRETO, BRAZIL

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S166-S166
Author(s):  
Cristina Del-Ben ◽  
Shuhama Rosana ◽  
Camila Loureiro ◽  
Taciana Ragazzi ◽  
Daniela Zanatta ◽  
...  
Keyword(s):  
Catchment Area ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

Clozapine use – has practice changed?

2020 ◽  
Vol 34 (5) ◽  
pp. 567-573
Author(s):  
Roberta Rowntree ◽  
Sean Murray ◽  
Felicity Fanning ◽  
Dolores Keating ◽  
Atilla Szigeti ◽  
...  
Keyword(s):  
Hospital Admissions ◽  
First Episode Psychosis ◽  
Prescribing Patterns ◽  
First Episode ◽  
Service Utilisation ◽  
Treatment Resistant ◽  
Nice Guidelines ◽  
Episode Psychosis ◽  
The Mean ◽  
The Impact

Background: One-third of individuals with schizophrenia have treatment-resistant illness. Of these, up to 60% will respond to clozapine treatment. Aims: This study retrospectively examined clozapine prescribing patterns against National Institute for Health and Care Excellence (NICE) guidelines as treatment-resistant illness emerged in a first-episode psychosis cohort. Methods: A total of 339 individuals with a first-episode psychosis were included in the study. Clozapine prescribing patterns were compared against the NICE guidelines and the impact of clozapine use on one index of service utilisation (hospitalisation) was assessed. Results: A total of 32 individuals (9.4%) from the cohort were prescribed clozapine. The mean time to clozapine trial was 2.1 years (SD 1.95; range 0.17–6.25). The mean number of adequate trials of antipsychotic prior to starting clozapine was 2.74 (SD 1.13; range 1–5). Following clozapine initiation, mean hospital admissions per year reduced from 2.3 to 0.3 ( p=0.00). Mean hospital days pre- and post-clozapine also reduced (147 vs. 53; p=0.00). In total, 18 patients discontinued clozapine use during follow-up – 5 temporarily and 13 permanently. Conclusions: Patients are being prescribed clozapine earlier than previously demonstrated, though delays are still evident, and many patients discontinue treatment. More work needs to be undertaken to understand and address factors which lead to its discontinuation.

scholarly journals A narrative analysis investigating the impact of first episode psychosis on siblings’ identity

Psychosis ◽  
2011 ◽  
Vol 3 (3) ◽  
pp. 216-225 ◽  
Author(s):  
Sharon Newman ◽  
Laura M. Simonds ◽  
Jo Billings
Keyword(s):  
Narrative Analysis ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
The Impact

scholarly journals HIV seropositivity in patients with first-episode psychosis

2007 ◽  
Vol 13 (3) ◽  
pp. 4 ◽  
Author(s):  
S Mashaphu ◽  
D L Mkize
Keyword(s):  
Psychotic Disorders ◽  
First Episode Psychosis ◽  
First Episode ◽  
Seroprevalence Rate ◽  
Hiv Seropositivity ◽  
Cross Sectional ◽  
Causal Direction ◽  
Episode Psychosis ◽  
Kwazulu Natal ◽  
The Impact

<p><strong>Background.</strong> In order to gauge the impact of the HIV epidemic on psychotic disorders, the magnitude and causal direction of the association between HIV infection and psychosis need to be examined closely.</p><p><strong>Objective.</strong> To determine the HIV seropositivity rate among adult patients presenting with first-episode psychosis (FEP) to Town Hill Hospital in Pietermaritzburg, KwaZulu-Natal.</p><p><strong>Design.</strong> A cross-sectional, point-prevalence study was done over a 6-month period.</p><p><strong>Results.</strong> Of the 63 FEP patients in the study, 48 tested HIV- negative and 15 tested positive, giving a seroprevalence rate of 23.8%.</p><p><strong>Conclusion.</strong> The prevalence of HIV seropositivity is high among patients with FEP.</p>

FC5E THE IMPACT OF AN EARLY DETECTION TEAM (LEO CAT) AND GP EDUCATION IN FIRST EPISODE PSYCHOSIS

2006 ◽  
Vol 86 ◽  
pp. S41 ◽  
Author(s):  
P. Power ◽  
N. Reynolds ◽  
H. Fisher ◽  
E. Iacoponi ◽  
P. Garety ◽  
...  
Keyword(s):  
Early Detection ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
The Impact

Poster #234 THE IMPACT OF TRAUMA IN CHILDHOOD AND ADULTHOOD ON CLINICAL AND SOCIAL FUNCTIONING IN FIRST EPISODE PSYCHOSIS

2012 ◽  
Vol 136 ◽  
pp. S365
Author(s):  
Helen J. Stain ◽  
Inge Joa ◽  
Tor K. Larsen ◽  
Jan Olav Johannessen ◽  
Wenche ten Velden Hegelstad ◽  
...  
Keyword(s):  
Social Functioning ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
The Impact
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