Harmonizing Human Health Studies in the Great Lakes

1996 ◽  
Vol 12 (3-4) ◽  
pp. 467-476 ◽  
Author(s):  
Heraline E. Hicks ◽  
Robert F. Spengler
Keyword(s):  
Great Lakes ◽  
Human Health ◽  
Health Effects ◽  
Tissue Bank ◽  
Human Populations ◽  
Toxic Substances ◽  
Potential Health ◽  
Research Activities ◽  
Health Studies ◽  
Human Health Effects

Epidemiological studies of exposed human populations can provide valuable evidence of human health effects. Information has been sparse on human health effects associated with consumption of contaminated Great Lakes fish. As part of its Great Lakes Human Health Effects Research Program, the Agency for Toxic Substances and Disease Registry (ATSDR) has funded ten projects. Of these studies, eight are epidemiologic investigations of human exposure and potential health effects from consumption of contaminated fish. To strengthen and to enhance the findings and comparability across the health studies, ATSDR has initiated several activities. These activities include harmonizing questionnaires, analytical protocols, human health end points, and contaminants tested. Also included is the establishment of a quality assurance and quality control (QA/QC) program and tissue bank. These activities will allow ATSDR to enhance exposure assessment in the Great Lakes basin. In addition, these research activities allow ATSDR to evaluate and to interpret data across all the projects, including a basin-wide health risk analysis on exposure, levels of contaminants or body burden, and the potential for human health effects from exposure to Great Lakes contaminants.

The Great Lakes: a Historical Overview

1996 ◽  
Vol 12 (3-4) ◽  
pp. 303-313 ◽  
Author(s):  
Heraline E. Hicks
Keyword(s):  
Great Lakes ◽  
Human Health ◽  
Health Effects ◽  
Great Lakes Basin ◽  
Adverse Health Effects ◽  
Freshwater Resource ◽  
Health Studies ◽  
Human Health Effects ◽  
By Products ◽  
Early Human

The Great Lakes are collectively the largest inland body of freshwater on this planet. For more than two hundred years, the Great Lakes basin has been used as a resource for industry, agriculture, shipping, and recreation. The physical characteristics of the basin and the long retention time of chemicals in the lakes combine to make this huge freshwater resource a repository for chemical by-products of these activities. Many of the more than one thousand chemicals detected in the waters, sediment, or biota of the Great Lakes have known toxic effects. This overview will identify the 11 most persistent toxic chemicals known as "critical" Great Lakes pollutants. It also will describe some of the adverse health effects that have been observed in fish and other wildlife because of exposure to these pollutants. Finally. it will discuss some of the early human health studies that 1) have demonstrated a correlation between increased body burdens and fish consumption, and 2) suggest an association between consumption of contaminated Great Lakes fish and adverse human health effects.

Strategic Elements of Atsdr's Great Lakes Human Health Effects Research Program

1996 ◽  
Vol 12 (3-4) ◽  
pp. 315-325 ◽  
Author(s):  
Christopher T. Derosa ◽  
Barry L. Johnson
Keyword(s):  
At Risk ◽  
Great Lakes ◽  
Human Health ◽  
Health Effects ◽  
Research Program ◽  
Research Effort ◽  
Great Lakes Basin ◽  
Potential Health ◽  
At Risk Populations ◽  
Human Health Effects

The goal of the Agency for Toxic Substances and Disease Registry's (ATSDR) Great Lakes Human Health Effects Research Program is to identify at-risk populations and to prevent potential human health effects associated with exposure to chemical contaminants in the Great Lakes basin. While this research effort is mandated by the Great Lakes Critical Programs Act of 1990, it also represents a significant opportunity to define a broader model or strategy for other regional or systems-level studies of potential health effects in at-risk populations. This article describes the strategy developed by ATSDR for this purpose in the Great Lakes Basin, as well as the program's specific research objectives and current status. It also outlines the projected implications of this research effort for greater comprehension of the potential health effects of exposure to contaminants in the Great Lakes Basin.

ATSDRʼs GREAT LAKES HUMAN HEALTH EFFECTS RESEARCH PROGRAM

Epidemiology ◽  
1996 ◽  
Vol 7 (Supplement) ◽  
pp. S39
Author(s):  
H E HIÇKS ◽  
W CIBULAS ◽  
Z ROSEMOND ◽  
C DeROSA
Keyword(s):  
Great Lakes ◽  
Human Health ◽  
Health Effects ◽  
Research Program ◽  
Human Health Effects

scholarly journals Risk Assessment of Emitted Particle-bound Polycyclic Aromatic Hydrocarbons from Lignite-biomass Pelletization Burning: Size Distribution and Human Health Effects

2018 ◽  
Vol 16 (10) ◽  
pp. 805-816
Author(s):  
Rithy KAN ◽  
Thaniya KAOSOL ◽  
Perapong TEKASAKUL ◽  
Surajit TEKASAKUL
Keyword(s):  
Risk Assessment ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Human Health ◽  
Size Distribution ◽  
Health Effects ◽  
Aromatic Hydrocarbons ◽  
Ultrafine Particles ◽  
Toxic Substances ◽  
Polycyclic Aromatic ◽  
Human Health Effects

Risk assessment of emitted particle polycyclic aromatic hydrocarbons (PAHs) from lignite-biomass pelletization burning focusing on size distribution and human health effects are investigated. The particles and PAHs are experimented by a tube furnace and high performance liquid chromatography coupled diode array and fluorescence detectors (HPLC-DAD/FLD), respectively. The carcinogenic, mutagenic, and toxic potencies of PAHs are also discussed in relative to the size distribution of emitted particle PAHs. The results indicate that the carcinogenic, mutagenic, and toxic potencies of PAHs are like to accumulate in the ultrafine particles finer than 0.65 µm. The ultrafine particles contribute the largest PAHs existences of carcinogenic, mutagenic and toxic substances; even though they register in the small mass fraction of PAHs.  Moreover, the co-pellets burning can reduce the values of carcinogenic PAHs, carcinogenic equivalency quotients (BaP-TEQ), mutagenic equivalency quotients (BaP-MEQ), and toxic equivalency quotients (TCDD-TEQ) by more than 60%.

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