Clinical Application of Experimental Cortical Dysplasia in Rats

2004 ◽  
Vol 19 (3) ◽  
pp. 351-356
Author(s):  
Tatsuya Tanaka ◽  
Hiroshige Tsuda ◽  
Kiyotaka Hashizume ◽  
Juro Sakurai ◽  
Akira Hodozuka ◽  
...  
Keyword(s):  
Surgical Outcome ◽  
Focal Cortical Dysplasia ◽  
Experimental Studies ◽  
Intractable Epilepsy ◽  
Cortical Dysplasia ◽  
Surgical Results ◽  
Postoperative Results ◽  
Epileptiform Discharges ◽  
Pathologic Classification

This report details clinical and experimental studies of focal cortical dysplasia. The first part deals with 14 surgical cases of children with intractable epilepsy. At surgery, intraoperative electrocorticography was performed to localize the epileptic foci under neuroleptanalgesia. Thirteen patients showed epileptiform discharges on this preresection electrocorticography. All foci in noneloquent areas were resected. Patients who had undergone total lesionectomy with complete focus resection showed the most favorable postoperative results. However, the positive correlation between the intraoperative electrocorticographic findings and the pathologic classification of cortical dysplasia was not found in the present study. Nine patients have been seizure free with reduced medication and two patients have achieved worthwhile improvement. We conclude that intraoperative electrocorticography can improve the surgical outcome for intractable epilepsy by localizing epileptic foci for resection. The second part describes a kainic acid—induced experimental model of focal cortical dysplasia, which demonstrated not only the epileptic properties of the dysplasia but also the perilesional epileptogenicity. The findings supported the surgical results for the patients with focal cortical dysplasia. ( J Child Neurol 2005;20:351—356).

Surgical outcome and predictive factors in adult patients with intractable epilepsy and focal cortical dysplasia

2006 ◽  
Vol 113 (2) ◽  
pp. 65-71 ◽  
Author(s):  
A. M. Siegel ◽  
G. D. Cascino ◽  
F. B. Meyer ◽  
W. R. Marsh ◽  
B. W. Scheithauer ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Surgical Outcome ◽  
Focal Cortical Dysplasia ◽  
Intractable Epilepsy ◽  
Cortical Dysplasia ◽  
Adult Patients

Surgical treatment of intractable epilepsy associated with focal cortical dysplasia

2008 ◽  
Vol 25 (3) ◽  
pp. E6 ◽  
Author(s):  
Roberto Jose Diaz ◽  
Elisabeth M. S. Sherman ◽  
Walter J. Hader
Keyword(s):  
Refractory Epilepsy ◽  
Functional Neuroimaging ◽  
Focal Cortical Dysplasia ◽  
Intractable Epilepsy ◽  
Cortical Dysplasia ◽  
Complete Resection ◽  
Epileptogenic Zone ◽  
Malformations Of Cortical Development ◽  
Cortical Dysplasias

Focal cortical dysplasias (FCDs) are congenital malformations of cortical development that are a frequent cause of refractory epilepsy in both children and adults. With advances in structural and functional neuroimaging, these lesions are increasingly being identified as a cause of intractable epilepsy in patients undergoing surgical management for intractable epilepsy. Comprehensive histological classification of FCDs with the establishment of uniform terminology and reproducible pathological features has aided in our understanding of FCDs as an epilepsy substrate. Complete resection of FCDs and the associated epileptogenic zone can result in a good surgical outcome in the majority of patients.

Surgical outcome for focal cortical dysplasia: an analysis of recent surgical series

2010 ◽  
Vol 6 (5) ◽  
pp. 452-458 ◽  
Author(s):  
Joshua J. Chern ◽  
Akash J. Patel ◽  
Andrew Jea ◽  
Daniel J. Curry ◽  
Youssef G. Comair
Keyword(s):  
Functional Imaging ◽  
Surgical Outcome ◽  
Focal Cortical Dysplasia ◽  
Intractable Epilepsy ◽  
Cortical Dysplasia ◽  
Prognostic Indicators ◽  
Seizure Outcome ◽  
Clinical Presentations ◽  
Number Of Patients ◽  
Selection For

Object Focal cortical dysplasia (FCD) is an important cause of intractable epilepsy and is at times treatable by resection. The now widespread use of MR imaging and recent advancement of functional imaging have increased the number of patients undergoing surgical treatment for FCD. The objective of this review is to critically examine and to provide a summary of surgical series on FCD published since 2000. Methods Studies concerning surgery for FCD were identified from MEDLINE and references of selected articles and book chapters. Data from these included studies were summarized and analyzed to identify factors correlated with seizure outcome. Results Sixteen studies were identified, and 469 patients met our selection criteria. Seizure-free outcome at 1-year postoperatively was achieved in 59.7% of the patients. Children and adults were equally likely to benefit from the surgery. Complete resection (OR 13.7, 95% CI 6.68–28.1; p < 0.0001) and temporal location (OR 2.15, 95% CI 1.26–3.69; p = 0.0073) were two positive prognostic indicators of seizure-free outcome. Utilization of invasive monitoring did not affect the chance of seizure remission, but firm conclusions could not be drawn because patients were not randomized. Conclusions The advancement of modern imaging has transformed the process of surgical candidate selection for partial epilepsy due to FCD. Patients from recent surgical series were more homogeneous in their clinical presentations and might represent FCD as an independent pathological entity. This likely explained the improved surgical outcome for this group of patients. These reports also documented the increased utilization of functional imaging, but their efficacy needs to be verified with further studies.

Intravenous Immunoglobulin as a Treatment for Intractable Epilepsy Secondary to Focal Cortical Dysplasia: A Meta-analysis

2017 ◽  
Vol 76 ◽  
pp. 79-81 ◽  
Author(s):  
Fatema Al Amrani ◽  
Roy Dudley ◽  
Luis E. Bello-Espinosa ◽  
Bernard Rosenblatt ◽  
Myriam Srour ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Focal Cortical Dysplasia ◽  
Meta Analysis ◽  
Intractable Epilepsy ◽  
Cortical Dysplasia

scholarly journals New Classification of Focal Cortical Dysplasia: Application to Practical Diagnosis

1970 ◽  
Vol 2 (2) ◽  
pp. 38-42 ◽  
Author(s):  
Yoon-Sung Bae ◽  
Hoon-Chul Kang ◽  
Heung Dong Kim ◽  
Se Hoon Kim
Keyword(s):  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
New Classification

scholarly journals Neuropathology of Temporal Lobe Epilepsy

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Fahd Al Sufiani ◽  
Lee Cyn Ang
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Wide Range ◽  
Pathologic Findings ◽  
Pathologic Lesions ◽  
Recent Classification ◽  
Associated Tumors

Pathologic findings in surgical resections from patients with temporal lobe epilepsy include a wide range of diagnostic possibilities that can be categorized into different groups on the basis of etiology. This paper outlines the various pathologic entities described in temporal lobe epilepsy, including some newly recognized epilepsy-associated tumors, and briefly touch on the recent classification of focal cortical dysplasia. This classification takes into account coexistent pathologic lesions in focal cortical dysplasia.

scholarly journals Type II focal cortical dysplasia: Electroclinical phenotype and surgical outcome related to imaging

Epilepsia ◽  
2012 ◽  
Vol 53 (2) ◽  
pp. 349-358 ◽  
Author(s):  
Francine Chassoux ◽  
Elisabeth Landré ◽  
Charles Mellerio ◽  
Baris Turak ◽  
Michael W. Mann ◽  
...  
Keyword(s):  
Surgical Outcome ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii
Sign in / Sign up

Export Citation Format

Share Document