Novel poly(glycidyl methacrylate-b-propylene oxide-b-glycidyl methacrylate) derivatives with low cytotoxicity and efficient gene delivery

2011 ◽  
Vol 26 (4) ◽  
pp. 388-404 ◽  
Author(s):  
Feng Li ◽  
Ming Ma ◽  
Zhe-Fan Yuan ◽  
Jing-Yi Huang ◽  
Ren-Xi Zhuo
Keyword(s):  
Gene Delivery ◽  
Propylene Oxide ◽  
Glycidyl Methacrylate ◽  
Efficient Gene ◽  
Low Cytotoxicity

Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery

2019 ◽  
Vol 7 (11) ◽  
pp. 1875-1881 ◽  
Author(s):  
Hongtao Chen ◽  
Shusen You ◽  
Qing Cai ◽  
Yang Zheng ◽  
Liqun Zhang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Glycidyl Methacrylate ◽  
Dna Delivery ◽  
Atom Transfer ◽  
Design And Synthesis ◽  
Efficient Gene ◽  
Low Cytotoxicity ◽  
Delivery Efficiency

A fluorescent amino poly(glycidyl methacrylate) (PGOHMA) was synthesized by atom transfer radical polymerization (ATRP) and post-polymerization. PGOHMA has low cytotoxicity and high DNA delivery efficiency.

Development of new self-assembled cationic amino liposomes for efficient gene delivery

2020 ◽  
Vol 8 (11) ◽  
pp. 3021-3025 ◽  
Author(s):  
Yihang Wu ◽  
Yue Xiong ◽  
Ling Wang ◽  
Quanming Zhou ◽  
Linxian Li ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Self Assembling ◽  
Efficient Gene ◽  
Self Assembled ◽  
Low Cytotoxicity

A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.

Multi-arm carriers composed of an antioxidant lignin core and poly(glycidyl methacrylate-co-poly(ethylene glycol)methacrylate) derivative arms for highly efficient gene delivery

2015 ◽  
Vol 3 (34) ◽  
pp. 6897-6904 ◽  
Author(s):  
Shan Jiang ◽  
Dan Kai ◽  
Qing Qing Dou ◽  
Xian Jun Loh
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Glycidyl Methacrylate ◽  
Atom Transfer ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Efficient Gene ◽  
Poly Ethylene

A lignin-based copolymer with good biocompability was successfully prepared via atom transfer radical polymerization (ATRP) for efficient gene delivery.

scholarly journals Aromatic Thioacetal-Bridged ROS-Responsive Nanoparticles as Novel Gene Delivery Vehicles

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2061 ◽  
Author(s):  
Guo-Qing Lin ◽  
Wen-Jing Yi ◽  
Qiang Liu ◽  
Xue-Jun Yang ◽  
Zhi-Gang Zhao
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Zeta Potentials ◽  
Sar Studies ◽  
Gene Delivery Vectors ◽  
Efficient Gene ◽  
Delivery Vehicles ◽  
Low Cytotoxicity

In this report, a series of polycations are designed and synthesized by conjugating reactive oxygen species (ROS)-responsive thioacetal-linkers to low molecular weight (LMW) polyethylenimine (PEI) via ring-opening polymerization. Their structure–activity relationships (SARs) as gene delivery vectors are systematically studied. Although the MWs of the target polymers are only ~9 KDa, they show good DNA binding ability. The formed polyplexes, which are stable toward serum but decomposed under ROS-conditions, have appropriate sizes (180~300 nm) and positive zeta-potentials (+35~50 mV). In vitro experiments reveal that these materials have low cytotoxicity, and higher transfection efficiency (TE) than controls. Furthermore, the title polymers exhibit excellent serum tolerance. With the present of 10% serum, the TE of the polymers even increases up to 10 times higher than 25 KDa PEI and 9 times higher than Lipofectamine 2000. The SAR studies also reveal that electron-withdrawing groups on the aromatic ring in 4a may benefit to balance between the DNA condensation and release for efficient gene transfection.

Highly water-soluble perylenediimide-cored poly(amido amine) vector for efficient gene transfection

2014 ◽  
Vol 2 (20) ◽  
pp. 3079-3086 ◽  
Author(s):  
Zejun Xu ◽  
Bicheng He ◽  
Wei Wei ◽  
Kelan Liu ◽  
Meizhen Yin ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gene Transfection ◽  
Water Soluble ◽  
Live Cells ◽  
High Efficacy ◽  
Efficient Gene ◽  
Amine Groups ◽  
Low Cytotoxicity

A highly water-soluble perylenediimide-core poly(amido amine) (PDI-PAmAm) with peripheral amine groups has been synthesized. PDI-PAmAm can be rapidly internalized into live cells with high efficacy of gene delivery and low cytotoxicity.

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