Multiple drug allergy syndrome in pregnancy: Lessons for sexual health physicians

Co-existence of multiple drug allergies and pregnancy often results in vexing dilemmas for physicians. A 21-year-old pregnant woman presented with asymptomatic cervicitis with dual infection with Chlamydia trachomatis and Neisseria gonorrhoeae during her third trimester. She reported a history of generalised rash with mucous membrane involvement following use of both macrolides and penicillins. Her gonococcal infection was successfully treated with a single dose of intramuscular gentamicin and chlamydial infection with oral clindamycin and rifampicin.

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Macrogol hypersensitivity in multiple drug allergy

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2011.08.008 ◽

2011 ◽

Vol 107 (6) ◽

pp. 542-543 ◽

Cited By ~ 7

Author(s):

Luisa Bommarito ◽

Sabrina Mietta ◽

Franco Nebiolo ◽

Massimo Geuna ◽

Giovanni Rolla

Keyword(s):

Drug Allergy ◽

Multiple Drug ◽

Multiple Drug Allergy

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Sevoflurane Allergy: Truth or a Myth? a Rare Case Report of Multiple Drug Allergy

ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter ◽

10.18311/isacon-karnataka/2017/ep031 ◽

2017 ◽

Author(s):

N. Vijetha ◽

K. Vinodan

Keyword(s):

Case Report ◽

Drug Allergy ◽

Rare Case ◽

Multiple Drug ◽

Rare Case Report ◽

Multiple Drug Allergy

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Factors Associated with Self-Reported Drug Allergies in a Large Chronic Spontaneous Urticaria Cohort

Current Drug Safety ◽

10.2174/1574886315666201002153354 ◽

2020 ◽

Vol 15 ◽

Author(s):

Christine Rauscher ◽

Andrej A. Petrov ◽

Merritt L. Fajt

Keyword(s):

General Population ◽

Drug Allergy ◽

Older Age ◽

Chronic Spontaneous Urticaria ◽

Multiple Drug ◽

Chi Square ◽

White Race ◽

Single Drug ◽

Common Drug ◽

Multiple Drug Allergy

Rationale: Chronic spontaneous urticaria (CSU) is characterized by recurrent hives without a known trigger. While certain drugs are associated with urticaria exacerbations, the overall drug allergy incidence in CSU is unknown. We hypothesized the incidence of drug allergy in CSU would be greater than the general population and that there would be distinguishing clinical features of drug-allergic CSU patients. Methods: 362 adult CSU patients seen over a 10-year period at a University Allergy/Asthma clinic were identified. Patients reported no drug allergies or any drug allergy. Multiple drug allergies were defined as allergies to ≥ 2 chemically unrelated drugs. Using Chi-square or Wilcoxon analysis, we compared demographic features of CSU with and without drug allergy and with multiple vs. single drug allergy. Results and Discussion: Overall, 202 CSU patients (56%) reported drug allergy. Drug allergic CSU patients were older, with a greater proportion of whites and higher BMI vs. CSU without drug allergy (p=0.002, p=0.047, p=0.004, respectively). Penicillin was the most common drug allergy, with urticaria the most frequently reported reaction. Female sex, white race, older age at visit and co-existing asthma were more common in multiple drug allergy (n=115) vs. single drug allergy (p=0.002, p=0.02, p=0.03, p=0.0002, respectively). Conclusion: In CSU, the prevalence of self-reported drug allergies was higher than the general population. Drug allergy associated with older age, white race and higher BMI while multiple drug allergy also associated with asthma. These CSU sub-populations should be studied to avoid the potential for morbidity associated with less efficacious and more costly drugs.

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Coagulation cascade and fibrinolysis in patients with multiple-drug allergy syndrome

Annals of Allergy Asthma & Immunology ◽

10.1016/s1081-1206(10)60403-6 ◽

2008 ◽

Vol 100 (1) ◽

pp. 44-48 ◽

Cited By ~ 13

Author(s):

Riccardo Asero ◽

Alberto Tedeschi ◽

Piersandro Riboldi ◽

Samantha Griffini ◽

Erika Bonanni ◽

...

Keyword(s):

Drug Allergy ◽

Coagulation Cascade ◽

Multiple Drug ◽

Multiple Drug Allergy

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Reliability and validity of the Thai Drug Hypersensitivity Quality of Life Questionnaire: a multi-center study

International Journal for Quality in Health Care ◽

10.1093/intqhc/mzy207 ◽

2018 ◽

Vol 31 (7) ◽

pp. 527-534 ◽

Cited By ~ 2

Author(s):

Yuda Chongpison ◽

Pawinee Rerknimitr ◽

Cameron Hurst ◽

Pungjai Mongkolpathumrat ◽

Sirinoot Palapinyo ◽

...

Keyword(s):

Quality Of Life ◽

Drug Allergy ◽

Drug Hypersensitivity ◽

World Health ◽

Multiple Drug ◽

Life Questionnaire ◽

Significant Difference ◽

Life Threatening ◽

Multiple Drug Allergy

Abstract Objective To adapted the Drug Hypersensitivity Quality of Life (DrHy-Q) Questionnaire from Italian into Thai and assessed its validity and reliability. Design Prospectively recruited during January 2012–May 2017. Setting Multicenter; six Thai tertiary university hospitals. Study Participants Total of 306 patients with physician-diagnosed drug hypersensitivity. Interventions Internal consistency and test–retest reliability were evaluated among 68 participants using Cronbach’s ɑ and intra-class correlation coefficient (ICC). The validity of Thai DrHy-Q was assessed among 306 participants who completed World Health Organization Quality of Life-BREF (WHOQOL-BREF-THAI). Construct and divergent validities were assessed for Thai DrHy-Q. Known-groups validity assessing discriminating ability was conducted in Thai DrHy-Q and WHOQOL-BREF-THAI. Main outcome measures Validity; reliability; single vs. multiple drug allergy; non-severe cutaneous adverse reactions (SCAR) vs. SCAR. Results Thai DrHy-Q showed good reliability (Cronbach’s ɑ = 0.94 and ICC = 0.8). Unidimensional factor structure was established by confirmatory factor analysis (CFI&TLI = 0.999, RMSEA = 0.02). Divergent validity was confirmed by weak correlation between Thai DrHy-Q and WHOQOL-BREF-THAI domains (Pearson’s r = −0.41 to −0.19). Known-groups validity of Thai DrHy-Q was confirmed with significant difference between patients with and without life-threatening SCAR (P = 0.02) and patients with multiple implicated drug classes vs. those with one class (P < 0.01); while WHOQOL-BREF-THAI could differentiate presence of life-threatening SCAR (P < 0.01) but not multiple-drug allergy. Conclusions Thai DrHy-Q was reliable and valid in evaluating quality of life among patients with drug hypersensitivity. Thai DrHy-Q was able to discriminate serious drug allergy phenotypes from non-serious manifestations in clinical practice and capture more specific drug-hypersensitivity aspects than WHOQOL-BREF-THAI.

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