Lack of association of mannose-binding lectin gene polymorphisms with development and clinical manifestations of systemic lupus erythematosus in Chinese children

Lupus ◽  
2009 ◽  
Vol 18 (4) ◽  
pp. 372-376 ◽  
Author(s):  
YC Tsai ◽  
TC Yao ◽  
ML Kuo ◽  
TT Cheng ◽  
JL Huang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Clinical Manifestations ◽  
Mannose Binding Lectin ◽  
Chinese Children ◽  
Systemic Lupus ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin gene polymorphisms in Brazilian patients with systemic lupus erythematosus

Lupus ◽  
2009 ◽  
Vol 19 (3) ◽  
pp. 280-287 ◽  
Author(s):  
OA Monticielo ◽  
JAB Chies ◽  
T. Mucenic ◽  
GG Rucatti ◽  
JMZ Júnior ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Mannose Binding Lectin ◽  
Systemic Lupus ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians

2011 ◽  
Vol 72 (6) ◽  
pp. 516-521 ◽  
Author(s):  
Paula Sandrin-Garcia ◽  
Lucas André Cavalcanti Brandão ◽  
Antônio Victor Campos Coelho ◽  
Rafael Lima Guimarães ◽  
João Alexandre Trés Pancoto ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Mannose Binding Lectin ◽  
Systemic Lupus ◽  
Lectin Gene ◽  
Functional Polymorphisms ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin serum levels in patients with systemic lupus erythematosus: association with thrombocytopaenia and seizure

Lupus ◽  
2017 ◽  
Vol 27 (3) ◽  
pp. 372-379 ◽  
Author(s):  
J Z Cieslinski ◽  
T L Skare ◽  
R Nisihara ◽  
I J De Messias-Reason ◽  
S R R Utiyama
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Serum Levels ◽  
Mannose Binding Lectin ◽  
Lectin Pathway ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin

The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease onset and clinical findings in SLE patients. Serum samples were analysed in 195 patients and 145 healthy controls from southern Brazil. Patients with high MBL levels (above 2000 ng/ml) showed a significant increase in the frequency of thrombocytopaenia ( p = 0.007; OR = 2.71; 95% CI = 1.32–5.55); and seizures ( p = 0.034; OR = 2.61; 95% CI = 1.07–6.37). A positive correlation between disease activity and MBL levels (>2000 ng/ml; p = 0.031, rho = 0.279) as well as of MBL concentration with accumulated organ damage ( p = 0.021; rho = 0.232) was observed. Our results suggest a role for MBL in the development of clinical manifestations such as thrombocytopaenia and seizures in SLE patients. These findings corroborate the participation of the lectin pathway of complement in the pathophysiologic mechanisms underlying clinical manifestations of SLE.

scholarly journals Mannose-binding lectin gene polymorphism in Greek systemic lupus erythematosus patients

Rheumatology ◽  
1997 ◽  
Vol 36 (11) ◽  
pp. 1238b-1239b ◽  
Author(s):  
D. Carthy ◽  
A. Hajeer ◽  
B. Ollier ◽  
K. Tarassi ◽  
C. Papasteriades ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Mannose Binding Lectin ◽  
Systemic Lupus ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: Two case-control studies and a meta-analysis

2005 ◽  
Vol 52 (12) ◽  
pp. 3966-3974 ◽  
Author(s):  
Young Ho Lee ◽  
Torsten Witte ◽  
Tanja Momot ◽  
Reinhold E. Schmidt ◽  
Kenneth M. Kaufman ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Mannose Binding Lectin ◽  
Case Control Studies ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin
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