scholarly journals Mannose binding lectin (MBL) 2 gene polymorphism & its association with clinical manifestations in systemic lupus erythematosus (SLE) patients from western India

2015 ◽  
Vol 141 (2) ◽  
pp. 199 ◽  
Author(s):  
Anita Nadkarni ◽  
Vandana Pradhan ◽  
Prathamesh Surve ◽  
Anjali Rajadhyaksha ◽  
Vinod Rajendran ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Mannose Binding Lectin ◽  
Western India ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose binding lectin 2 promotor-221 X/Y gene polymorphism in Egyptian systemic lupus erythematosus patients

2016 ◽  
Vol 38 (4) ◽  
pp. 301-306 ◽  
Author(s):  
Eman Harraz ◽  
Enas Hammad ◽  
Mohammed Darwish ◽  
Manal Awad ◽  
Sheren Salah ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Mannose Binding Lectin ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin serum levels in patients with systemic lupus erythematosus: association with thrombocytopaenia and seizure

Lupus ◽  
2017 ◽  
Vol 27 (3) ◽  
pp. 372-379 ◽  
Author(s):  
J Z Cieslinski ◽  
T L Skare ◽  
R Nisihara ◽  
I J De Messias-Reason ◽  
S R R Utiyama
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Serum Levels ◽  
Mannose Binding Lectin ◽  
Lectin Pathway ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin

The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease onset and clinical findings in SLE patients. Serum samples were analysed in 195 patients and 145 healthy controls from southern Brazil. Patients with high MBL levels (above 2000 ng/ml) showed a significant increase in the frequency of thrombocytopaenia ( p = 0.007; OR = 2.71; 95% CI = 1.32–5.55); and seizures ( p = 0.034; OR = 2.61; 95% CI = 1.07–6.37). A positive correlation between disease activity and MBL levels (>2000 ng/ml; p = 0.031, rho = 0.279) as well as of MBL concentration with accumulated organ damage ( p = 0.021; rho = 0.232) was observed. Our results suggest a role for MBL in the development of clinical manifestations such as thrombocytopaenia and seizures in SLE patients. These findings corroborate the participation of the lectin pathway of complement in the pathophysiologic mechanisms underlying clinical manifestations of SLE.

scholarly journals Mannose-binding lectin gene polymorphism in Greek systemic lupus erythematosus patients

Rheumatology ◽  
1997 ◽  
Vol 36 (11) ◽  
pp. 1238b-1239b ◽  
Author(s):  
D. Carthy ◽  
A. Hajeer ◽  
B. Ollier ◽  
K. Tarassi ◽  
C. Papasteriades ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Mannose Binding Lectin ◽  
Systemic Lupus ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

2012 ◽  
Vol 14 (5) ◽  
pp. R218 ◽  
Author(s):  
Aditya K Panda ◽  
Jyoti R Parida ◽  
Rina Tripathy ◽  
Sarit S Pattanaik ◽  
Balachandran Ravindran ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mannose Binding Lectin ◽  
Systemic Lupus Erythematosus Disease ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin
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