Risk of systemic lupus erythematosus in patients with human papillomavirus infection: a population-based retrospective cohort study

Lupus ◽  
2018 ◽  
Vol 27 (14) ◽  
pp. 2279-2283 ◽  
Author(s):  
L-H Shi ◽  
J-Y Huang ◽  
Y-Z Liu ◽  
J-Y Chiou ◽  
R Wu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Human Papillomavirus ◽  
Lupus Erythematosus ◽  
Hpv Infection ◽  
Population Based ◽  
Systemic Lupus ◽  
Insurance Program ◽  
Papillomavirus Infection ◽  
Hazard Ratios ◽  
Insurance Database

Background: Viral infection contributing to systemic lupus erythematosus (SLE) development has been largely reported. However, the SLE risk in patients with human papillomavirus (HPV) infection is unknown. Methods: Data were retrieved from the Longitudinal Health Insurance Database (2000) in Taiwan. We identified 43,567 patients with HPV infection and 174,268 age- and sex-matched uninfected controls from 2002 to 2012. Individuals were followed up from index date (first date of diagnosis with HPV) until the occurrence of SLE, at the end of the study (December 2013), or when they were withdrawn from the insurance program. The incidence rate ratio (IRR) was calculated using the univariate Poisson regression. The adjusted hazard ratios (aHRs) were calculated, and sensitive and subgroups analyses were also conducted. Results: Compared with the non-HPV controls, the IRR of SLE in HPV patients was 1.52 (95% confidence interval (CI): 1.09–2.12). The risk of SLE in HPV-infected individuals was significantly high (aHR: 1.48, 95% CI: 1.06–2.06) after adjusting for age, sex, and comorbidities. Men aged between 16 and 45 years were more susceptible to developing SLE (aHR: 21.57, 95% CI: 2.52–184.60, p = 0.0051). Conclusion: Our study showed a significantly higher risk of SLE among HPV-infected patients, especially in men aged between 16 and 45 years.

scholarly journals Systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review

2010 ◽  
Vol 30 (5) ◽  
pp. 665-672 ◽  
Author(s):  
Iuri Usêda Santana ◽  
Alline do Nascimento Gomes ◽  
Leomar D’Cirqueira Lyrio ◽  
Maria Fernanda Rios Grassi ◽  
Mittermayer Barreto Santiago
Keyword(s):  
Systematic Review ◽  
Systemic Lupus Erythematosus ◽  
Human Papillomavirus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Malignant Lesions

scholarly journals AB0407 HUMAN PAPILLOMA VIRUS (HPV) INFECTION AND CERVICAL CANCER PREVALENCE IN A PORTUGUESE UNIVERSITY HOSPITAL SINGLE-CENTER SYSTEMIC LUPUS ERYTHEMATOSUS COHORT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1504.3-1504
Author(s):  
J. Sousa Morais ◽  
D. G. Oliveira ◽  
R. Faria ◽  
A. Almeida ◽  
M. Brandão ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Lupus Erythematosus ◽  
Hpv Infection ◽  
University Hospital ◽  
Healthy Population ◽  
Single Center ◽  
Systemic Lupus ◽  
Patient Cohort

Background:About 12% of women worldwide are infected with Human Papillomavirus (HPV), the most frequent cause of cervical cancer (CC) - very prevalent (~ 7,5%) and preventable. National screening efforts are in use in several countries, including Portugal. Patients with Systemic Lupus Erythematosus (SLE) are at increased risk of HPV infection and CC when compared to the healthy population.Objectives:To evaluate the prevalence of HPV infection and rate of incidence of cervical neoplastic lesions in a SLE patient cohort followed at a university hospital.Methods:Retrospective single-center (35 year long, 463 SLE patient cohort) review of all female SLE patients’ local and online national health care records on HPV vaccination and CC screening.Results:Of the 463 SLE patients, 420 were women (91%), of which 322 had records on of HPV infection or CC developed. Mean patients’ current age was 48 years and all had screening for cervical pathology in the last 3 years. Thirty-three patients (11%) had HPV infection diagnosed at a mean age of 44 years. Twenty-seven (8%) of SLE patients were vaccinated for HPV: 8 (22%) of the infected patients had the vaccine, half after the HPV infection. Despite HPV infection, 49 patients (15%) had developed some cervical lesion, of which 41 (84% of cervical lesion) were suggestive of malignancy, and ultimately CC was diagnosed in 20 women (41%; 6% of total women), with a mean age at diagnosis of 45 years. All CC patients had history of HPV infection, but only 3 women (15%; 0,9% of total women) had been vaccinated against HPV, 2 after the diagnoses of CC and 1 before.Conclusion:In our population the prevalence of HPV was higher than reported for the general population using the World Health Organization database, conforming the higher risk of HPV infection in SLE patients. The prevalence of cervical cancer, however, was similar to the healthy population.References:[1]https://www.who.int/immunization/diseases/hpv/en/[2]Forman David (2012); “Global Burden of Human Papillomavirus and Related Diseases”, Vaccine, Elsevier Volume 30, Supplement 5, 20 November 2012[3]Grein Ingrid (2016), Department of Pediatric Immunology and Rheumatology, Netherland (2016), HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know, Pediatric Rheumatology, 2016Disclosure of Interests: :None declared

Incidence of cervical human papillomavirus infection in systemic lupus erythematosus women

Lupus ◽  
2017 ◽  
Vol 26 (9) ◽  
pp. 944-951 ◽  
Author(s):  
C Mendoza-Pinto ◽  
M García-Carrasco ◽  
V Vallejo-Ruiz ◽  
S Méndez-Martínez ◽  
A Taboada-Cole ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Human Papillomavirus ◽  
Lupus Erythematosus ◽  
Odds Ratio ◽  
Systemic Lupus ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Cyclophosphamide Dose ◽  
Cumulative Prevalence

Objectives Our objective was to study the incidence, persistence and clearance of human papillomavirus infection in systemic lupus erythematosus women and assess risk factors for persistence of human papillomavirus infection. Methods We carried out a prospective, observational cohort study of 127 systemic lupus erythematosus women. Patients were evaluated at baseline and at three years. Traditional and systemic lupus erythematosus women-related disease risk factors were collected. Gynaecological evaluations and cervical cytology screening were made. Human papillomavirus detection and genotyping were made by polymerase chain reaction and linear array. Results The cumulative prevalence of human papillomavirus infection increased from 22.8% at baseline to 33.8% at three years; p = < 0.001: 20.1% of patients experienced 43 incident infections. The risk of any human papillomavirus infection was 10.1 per 1000 patient-months. At three years, 47 (88.6%) prevalent infections were cleared. Independent risk factors associated with incident human papillomavirus infection included more lifetime sexual partners (odds ratio = 1.8, 95% confidence interval = 1.11–3.0) and cumulative cyclophosphamide dose (odds ratio = 3.9, 95% confidence interval = 1.2–12.8). Conclusions In systemic lupus erythematosus women, the cumulative prevalence of human papillomavirus infection, including high risk-human papillomavirus and multiple human papillomavirus infections, may increase over time. Most persistent infections were low risk-human papillomavirus. The number of lifetime sexual partners and the cumulative cyclophosphamide dose were independently associated with incident human papillomavirus infection.

Cervical human papillomavirus infection in Mexican women with systemic lupus erythematosus or rheumatoid arthritis

Lupus ◽  
2011 ◽  
Vol 21 (4) ◽  
pp. 365-372 ◽  
Author(s):  
W Rojo-Contreras ◽  
EM Olivas-Flores ◽  
JI Gamez-Nava ◽  
H Montoya-Fuentes ◽  
B Trujillo-Hernandez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Human Papillomavirus ◽  
Lupus Erythematosus ◽  
Mexican Women ◽  
Systemic Lupus ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Cervical Human Papillomavirus

scholarly journals Prevalence of cervical human papillomavirus infection in women with systemic lupus erythematosus

2012 ◽  
Vol 33 (2) ◽  
pp. 335-340 ◽  
Author(s):  
Leomar D. C. Lyrio ◽  
Maria Fernanda R. Grassi ◽  
Iuri U. Santana ◽  
Viviana G. Olavarria ◽  
Aline do N. Gomes ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Human Papillomavirus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Cervical Human Papillomavirus
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