Leukemoid Reaction and Preterm Birth: A Case Report of FIRS (Fetal Inflammatory Response Syndrome)

2021 ◽  
pp. 097321792110378
Author(s):  
Sara Tagliani ◽  
Luca Casadio ◽  
Caterina Radice ◽  
Ivana Bruno ◽  
Giancarlo Piccinini ◽  
...  
Keyword(s):  
Case Report ◽  
Preterm Birth ◽  
Inflammatory Response ◽  
Chronic Lung Disease ◽  
Intraventricular Hemorrhage ◽  
Periventricular Leukomalacia ◽  
Leukemoid Reaction ◽  
Congenital Leukemia ◽  
Developmental Impairment ◽  
Fetal Inflammatory Response

This article describes a case of severe hyperleukocytosis in a preterm infant with fetal inflammatory response syndrome (FIRS) associated with funisitis of umbilical cord and intrauterine inflammation. FIRS is a cause of leukocytosis in newborn, as well as leukemoid reaction in 21 trisomy, congenital leukemia, sepsis, and steroid prophylaxis. Inflammatory response syndrome is associated with high mortality, developmental impairment and complications of prematurity like intraventricular hemorrhage, chronic lung disease, periventricular leukomalacia, and sepsis.

Fetal inflammatory response to oral pathogens and preterm birth

2004 ◽  
Vol 191 (6) ◽  
pp. S28
Author(s):  
Kim Boggess ◽  
Susan Lieff ◽  
Kevin Moss ◽  
James Beck ◽  
Steven Offenbacher ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Inflammatory Response ◽  
Oral Pathogens ◽  
Fetal Inflammatory Response

scholarly journals Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models

2021 ◽  
Vol 7 (4) ◽  
pp. eabd3865
Author(s):  
Samantha Sheller-Miller ◽  
Enkhtuya Radnaa ◽  
Jae-Kwang Yoo ◽  
Eunsoo Kim ◽  
Kyungsun Choi ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Inflammatory Response ◽  
Immune Cells ◽  
Fluorescent Protein ◽  
Immune Cell ◽  
Innate Immune ◽  
Maternal Inflammation ◽  
Lps Challenge ◽  
Cell Profile ◽  
Fetal Inflammatory Response

Accumulation of immune cells and activation of the pro-inflammatory transcription factor NF-κB in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology. Reduction of the fetal inflammatory response and NF-κB activation are key strategies to minimize infection-associated PTB. Therefore, we engineered extracellular vesicles (exosomes) to contain an NF-κB inhibitor, termed super-repressor (SR) IκBα. Treatment with SR exosomes (1 × 1010 per intraperitoneal injection) after lipopolysaccharide (LPS) challenge on gestation day 15 (E15) prolonged gestation by over 24 hours (PTB ≤ E18.5) and reduced maternal inflammation (n ≥ 4). Furthermore, using a transgenic model in which fetal tissues express the red fluorescent protein tdTomato while maternal tissues do not, we report that LPS-induced PTB in mice is associated with influx of fetal innate immune cells, not maternal, into feto-maternal uterine tissues. SR packaged in exosomes provides a stable and specific intervention for reducing the inflammatory response associated with PTB.

scholarly journals Maternal SARS-CoV-2 Infection Associated to Systemic Inflammatory Response and Pericardial Effusion in the Newborn: A Case Report

2020 ◽  
Author(s):  
Andressa R O Lima ◽  
Cynthia C Cardoso ◽  
Priscilla R B Bentim ◽  
Carolina M Voloch ◽  
Átila D Rossi ◽  
...  
Keyword(s):  
Case Report ◽  
Pericardial Effusion ◽  
Inflammatory Response ◽  
Vertical Transmission ◽  
Systemic Inflammatory Response ◽  
Cardiac Complications ◽  
First Case ◽  
Clinical Consequences ◽  
Fetal Inflammatory Response

Abstract Vertical transmission of SARS-CoV-2 has already been described, while clinical consequences to the fetus are still under investigation. This article reports a case of systemic fetal inflammatory response and pericardial effusion. As far as is known, this is the first case of fetal/neonatal cardiac complications related to SARS-CoV-2 infection.

scholarly journals Micronutrients and Intrauterine Infection, Preterm Birth and the Fetal Inflammatory Response Syndrome

2003 ◽  
Vol 133 (5) ◽  
pp. 1668S-1673S ◽  
Author(s):  
Roberto Romero ◽  
Tinnakorn Chaiworapongsa ◽  
Jimmy Espinoza
Keyword(s):  
Preterm Birth ◽  
Inflammatory Response ◽  
Intrauterine Infection ◽  
Fetal Inflammatory Response

scholarly journals The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Robert Galinsky ◽  
Graeme R. Polglase ◽  
Stuart B. Hooper ◽  
M. Jane Black ◽  
Timothy J. M. Moss
Keyword(s):  
Preterm Birth ◽  
Inflammatory Response ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Physiological Mechanisms ◽  
Renal Outcomes ◽  
Histologic Chorioamnionitis ◽  
Preterm Rupture Of Membranes ◽  
Fetal Inflammatory Response

Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, and preterm rupture of membranes, is less common than subclinical/histologic chorioamnionitis, which is asymptomatic and defined by inflammation of the chorion, amnion, and placenta. Chorioamnionitis is often associated with a fetal inflammatory response. The fetal inflammatory response syndrome (FIRS) is defined by increased systemic inflammatory cytokine concentrations, funisitis, and fetal vasculitis. Clinical and epidemiological studies have demonstrated that FIRS leads to poor cardiorespiratory, neurological, and renal outcomes. These observations are further supported by experimental studies that have improved our understanding of the mechanisms responsible for these outcomes. This paper outlines clinical and experimental studies that have improved our current understanding of the mechanisms responsible for chorioamnionitis-induced preterm birth and explores the cellular and physiological mechanisms underlying poor cardiorespiratory, neural, retinal, and renal outcomes observed in preterm infants exposed to chorioamnionitis.

Fetal Inflammatory Response Syndrom: Leidet die zerebrale Sauerstoffversorgung?

2020 ◽  
Vol 224 (05) ◽  
pp. 243-243
Keyword(s):  
Inflammatory Response ◽  
Interleukin 6 ◽  
Fetal Inflammatory Response

Ein sogenanntes FIRS (fetal inflammatory response syndrome) liegt per Definition vor, wenn in Folge einer systemischen Aktivierung des fetalen Immunsystems im Nabelschnurblut erhöhte Interleukin-6(IL-6)-Spiegel gemessen werden. Die betroffenen Kinder haben ein erhöhtes Komplikations- und Sterberisiko. Beeinträchtigt das FIRS die zerebrale Sauerstoffversorgung von Frühgeborenen innerhalb der ersten Lebensminuten?

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