Inflammatory bowel disease-related fatigue is correlated with depression and gender

2018 ◽  
Vol 26 (5) ◽  
pp. 508-513 ◽  
Author(s):  
Philip Keightley ◽  
Rebecca E Reay ◽  
Paul Pavli ◽  
Jeffrey CL Looi
Keyword(s):  
Inflammatory Bowel Disease ◽  
Attachment Style ◽  
Functional Assessment ◽  
Bowel Disease ◽  
Depression Scale ◽  
Female Gender ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
Chronic Illness Therapy ◽  
Inflammatory Bowel

Objectives: Fatigue is a common and disabling problem in inflammatory bowel disease. We sought to explore the possible determinants of inflammatory bowel disease-associated fatigue including demographic, psychological and disease variables. Methods: Surveys were distributed to 100 patients undergoing infliximab infusion for inflammatory bowel disease in an infusion lounge, assessing attachment style (Experiences in Close Relationships Revised scale), fatigue (Functional Assessment of Chronic Illness Therapy Fatigue – Fatigue Subscore), and depression and anxiety (Hospital Anxiety and Depression Scale). Disease severity was assessed via file review through an independent gastroenterologist rating (Harvey–Bradshaw Index). Results: There were 67 responses. Depression, as measured by the Hospital Anxiety and Depression Scale, was found to be highly correlated with fatigue (Functional Assessment of Chronic Illness Therapy Fatigue – Fatigue Subscore). Anxiety, insecure attachment, disease severity and female gender were moderately correlated with fatigue. In a hierarchical regression model, depression and female gender emerged as significant predictors of variance in fatigue scores. Conclusions: Depression was the strongest predictor of variance in fatigue scores. Gender as a cause of fatigue in inflammatory bowel disease requires further exploration. Attachment style, however, may still help clinicians to conceptualise help-seeking behaviour and clinician-patient relationships in medically unexplained symptoms.

Hospital Anxiety and Depression Scale (HADS): Validation in Mexican patients with inflammatory bowel disease

2018 ◽  
Vol 41 (8) ◽  
pp. 477-482
Author(s):  
Jesús K. Yamamoto-Furusho ◽  
Andrea Sarmiento-Aguilar ◽  
Mario García-Alanis ◽  
Luis Enrique Gómez-García ◽  
Joel Toledo-Mauriño ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
Inflammatory Bowel ◽  
Mexican Patients

scholarly journals INFLAMMATORY BOWEL DISEASE: IMPACT ON SCORES OF QUALITY OF LIFE, DEPRESSION AND ANXIETY IN PATIENTS ATTENDING A TERTIARY CARE CENTER IN BRAZIL

2018 ◽  
Vol 55 (3) ◽  
pp. 202-207 ◽  
Author(s):  
Raquel Pellizzari CALIXTO ◽  
Cristina FLORES ◽  
Carlos Fernando FRANCESCONI
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
Inflammatory Bowel Disease Questionnaire ◽  
Inflammatory Bowel ◽  
Disease Questionnaire

ABSTRACT BACKGROUND: Inflammatory bowel disease frequently affects patients at working age, compromising their quality of life in several levels: physical, psychological, familial and social. Few studies have evaluated the impact of Inflammatory bowel disease on quality of life, anxiety and depression in Brazilian patients. OBJECTIVE: Evaluate quality of life and its correlation with psychological aspects of patients with inflammatory bowel disease through the Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale. METHODS: Cross-sectional study; Inflammatory Bowel Disease Questionnaire, Short Form-36 and Hospital Anxiety and Depression Scale were applied to consecutive outpatients in a tertiary referral center for inflammatory bowel disease. Harvey-Bradshaw Index and Truelove scores were used to evaluate Crohn’s disease and ulcerative colitis activity. Sample calculation: 113 patients for a significance level of 5%, power of 90% and a correlation coefficient of at least 0.3 between scales. Statistical analysis: Student-t test, Pearson and Spearman correlations. RESULTS: One hundred twenty patients participated in the study; mean age: 41.7 years; female: 58.3%; Crohn’s Disease: 69 patients. No low scores for quality of life were found across the four Inflammatory Bowel Disease Questionnaire domains; the Short Form-36 showed low scores in physical limitations (47.2±42.4) and emotional aspects (49.8±43.4); Hospital Anxiety and Depression Scale score presented a mean of 9.5±2.7 for anxiety and 8.7±2.0 for depression. Quality of life was decreased and Hospital Anxiety and Depression Scale did show increased indices of anxiety and depression, in both diseases only when clinically active. CONCLUSION: Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale showed that outpatients of a tertiary care center for inflammatory bowel disease in Brazil presented good quality of life. The worst quality of life was associated with the intensity of the disease activity.

scholarly journals Longitudinal Trajectory of Fatigue in Patients With Inflammatory Bowel Disease: A Prospective Study

2020 ◽  
Author(s):  
Nienke Z Borren ◽  
Millie D Long ◽  
Robert S Sandler ◽  
Ashwin N Ananthakrishnan
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Chronic Illness ◽  
Prospective Study ◽  
Functional Assessment ◽  
Bowel Disease ◽  
Symptom Resolution ◽  
Chronic Illness Therapy ◽  
Inflammatory Bowel ◽  
A Prospective Study

Abstract Background Fatigue is a disabling symptom in patients with inflammatory bowel disease (IBD). Its prevalence, mechanism, and impact remain poorly understood. We determined changes in fatigue status over time and identified predictors of incident or resolving fatigue. Methods This was a prospective study nested within the IBD Partners cohort. Participants prospectively completed the Multidimensional Fatigue Inventory and the Functional Assessment of Chronic Illness Therapy-Fatigue at baseline, 6 months, and 12 months. A Functional Assessment of Chronic Illness Therapy-Fatigue score ≤43 defined significant fatigue. Multivariable regression models using baseline covariates were used to identify risk factors for incident fatigue at 6 months and to predict the resolution of fatigue. Results A total of 2429 patients (1605 with Crohn disease, 824 with ulcerative colitis) completed a baseline assessment, and 1057 completed a second assessment at 6 months. Persistent fatigue (at baseline and at 6 months) was the most common pattern, affecting two-thirds (65.8%) of patients. One-sixth (15.7%) of patients had fatigue at 1 timepoint, whereas fewer than one-fifth (18.5%) of patients never reported fatigue. Among patients not fatigued at baseline, 26% developed fatigue at 6 months. The strongest predictor of incident fatigue was sleep disturbance at baseline (odds ratio, 2.91; 95% confidence interval, 1.48–5.72). In contrast, only 12.3% of those with fatigue at baseline had symptom resolution by month 6. Resolution was more likely in patients with a diagnosis of ulcerative colitis, quiescent disease, and an absence of significant psychological comorbidity. Conclusions Fatigue is common in patients with IBD. However, only a few fatigued patients experience symptom resolution at 6 or 12 months, suggesting the need for novel interventions to ameliorate its impact.

M1231 Functional Assessment of Chronic Illness Therapy-Fatigue (Facit-F) Scale is Valid in Patients With Inflammatory Bowel Disease

2010 ◽  
Vol 138 (5) ◽  
pp. S-359-S-360
Author(s):  
Andrew Tinsley ◽  
Eric A. Macklin ◽  
Joshua R. Korzenik ◽  
Jennifer Inra ◽  
Bruce E. Sands
Keyword(s):  
Inflammatory Bowel Disease ◽  
Chronic Illness ◽  
Functional Assessment ◽  
Bowel Disease ◽  
Chronic Illness Therapy ◽  
Inflammatory Bowel

scholarly journals P143 Depression and anxiety symptoms among patients with early inflammatory bowel disease during and after COVID-19 lockdown

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S228-S228
Author(s):  
L Sempere Robles ◽  
P Bernabeu ◽  
J Cameo ◽  
A Gutiérrez ◽  
G García ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Activity Index ◽  
Psychological Impact ◽  
Previous History ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Female Sex ◽  
Inflammatory Bowel

Abstract Background Patients with inflammatory bowel disease (IBD) are vulnerable to some psychological disorders. Here we describe the psychological impact of a COVID-19 pandemic lockdown in patients with IBD. Methods This multicenter prospective cohort study included 145 patients recently diagnosed with IBD. Data on clinical and demographic characteristics, anxiety and depression (Hospital Anxiety and Depression Scale), and IBD activity (the Modified Harvey Bradshaw Index for CD and Simple Clinical Colitis Activity Index for CU) were collected in two telephone surveys, during and after the first COVID-19 lockdown in Spain. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results During lockdown, 33.1% and 24.1% scored high on the anxiety and depression scales, respectively. Independent factors related to anxiety (all values ORs; 95% CIs) during lockdown were female sex (2; 1.2–5.4) and IBD activity (4.3; 1.8–10.4). Factors related to depression were comorbidity (3.3; 1.1–9.8), IBD activity (6; 1.9–18.1), use of biologics (2.9; 1.1–7.6), and living alone or with one person (3.1; 1.2–8.2). After lockdown, anxiety and depression symptoms showed significant improvement, with 24.8% and 15.2% having high scores for anxiety and depression, respectively. Factors related to post-lockdown anxiety were female sex (2.5; 1.01–6.3), Crohn’s disease (3.3; 1.3–8.5), and active IBD (4.1; 1.2–13.7). Factors associated with depression were previous history of mood and/or anxiety disorders (6.3; 1.6–24.9), active IBD (7.5; 2.1–26.8), and steroid use (6.4; 1.4–29). Conclusion Lockdown during the COVID-19 pandemic had a significant psychological impact in patients with IBD. Disease activity was related to the presence of anxiety and depression symptoms during and after lockdown.

scholarly journals P565 Illness perception as a clinical tool to detect mood disturbances (anxiety or depression) in inflammatory bowel disease patients

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S526-S526
Author(s):  
M L De Castro Parga ◽  
D Pereyra ◽  
L Sanromán ◽  
M Figueira ◽  
V Hernández ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Illness Perception ◽  
Depression Scale ◽  
Tertiary Hospital ◽  
Anxiety And Depression ◽  
Clinical Tool ◽  
Illness Perception Questionnaire ◽  
Ethical Approval ◽  
Inflammatory Bowel

Abstract Background In patients suffering from inflammatory bowel disease (IBD), a prevalence of anxiety and/or depression of 30–35% has been reported in phases of clinical inactivity, reaching up to 60–80% in the flare-ups. Moreover, the presence of psychological comorbidity is now considered to complicate the course of IBD. Our aim was to evaluate the relationship between mood disturbances and individual illness perception. Methods Patients attending our tertiary hospital IBD outpatient clinic were enrolled. They filled the “Hospital anxiety and depression scale” (HADS) and the “Brief illness perception questionnaire” (BIPQ). Sociodemographic characteristics, phenotype and clinical course of IBD were reviewed as well. Ethical approval of the study was obtained. Results A total of 201 patients were analyzed: male 102 (50.7%) female 99 (47.3%), UC 113 (56.2%), CD 88 (43.8%). The HADS prevalence of psychological pathology was 24%, (22% anxiety, 6.9% depression), and 17% patients previously were on mood medications. There were no differences between CU and EC, although EC patients tended to show more anxiety. Women had a higher prevalence of anxiety (29% vs 15.6%) and depression (9.6% vs 4.7%) than men (p=0.03 and p=0.009). Anxiety was also associated with previous IBD hospitalization (p=0.005), and depression with living alone (p=0.007). The BIPQ dimensions: consequences, concern and emotional response were statistically associated with the presence of psychological pathology, anxiety and depression (p=0.0005 each). Conclusion Mood disturbances are frequently found in IBD patients, especially among females. A negative individual illness perception of the consequences and emotions related to IBD seems to correlated strongly with the presence of anxiety and/ or depression in these patients.

scholarly journals A Prospective Pilot Randomized Study: Electroacupuncture vs. Sham Procedure for the Treatment of Fatigue in Patients With Quiescent Inflammatory Bowel Disease

2019 ◽  
Author(s):  
Diana Horta ◽  
Alba Lira ◽  
Meritxell Sanchez-Lloansi ◽  
Albert Villoria ◽  
Marcelo Teggiachi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Chronic Illness ◽  
Confidence Intervals ◽  
Functional Assessment ◽  
Bowel Disease ◽  
Clinical Remission ◽  
Randomized Study ◽  
Common Symptom ◽  
Chronic Illness Therapy ◽  
Inflammatory Bowel

Abstract Background Fatigue is a common symptom in patients with inflammatory bowel disease (IBD), and it often persists despite clinical remission. Acupuncture has been shown to be effective for treating fatigue in patients with many chronic diseases. The main objective of the study was to assess the efficacy of electroacupuncture (EAc), compared with sham EAc (ShEAc) or being on a waitlist (WL), for treating fatigue in patients with quiescent IBD in a single-blind randomized trial. Methods Fifty-two patients with IBD in clinical remission and fatigue were randomly assigned to 1 of 3 groups: EAc, ShEAc, or WL. Patients in the EAc and ShEAc groups received 9 sessions over 8 weeks. Fatigue was evaluated with the IBD-validated Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-FS). Results Baseline characteristics were similar in the 3 groups. Both EAc and ShEAc presented improved Functional Assessment of Chronic Illness Therapy-Fatigue Scale scores compared with baseline: the respective improvements were 9.53 (95% confidence intervals, 6.75–12.3, P < 0.001) and 5.46 points (95% confidence intervals, 2.7–9.7, P = 0.015), respectively. No significant changes were observed in the WL group. In the comparison of treatment groups, EAc was nonsignificantly better than ShEAc (EAc, 33.27 and ShEAc, 28.13, P = 0.168); both EAc and ShEAc improved fatigue scores significantly compared to WL (24.5; P = 0.01 and 0.04, respectively). Conclusions Both EAc and ShEAc reduced fatigue scores in IBD patients when compared to WL. No differences were observed between EAc and ShEAc, although the study was not powered to rule out a difference. Acupuncture may offer improvements to patients with few other treatment alternatives. Clinical Trials Org Id: NCT02733276.

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