Inflammatory Bowel Disease, the Hospital Anxiety and Depression Scale and Criterion Contamination

Objectives: Fatigue is a common and disabling problem in inflammatory bowel disease. We sought to explore the possible determinants of inflammatory bowel disease-associated fatigue including demographic, psychological and disease variables. Methods: Surveys were distributed to 100 patients undergoing infliximab infusion for inflammatory bowel disease in an infusion lounge, assessing attachment style (Experiences in Close Relationships Revised scale), fatigue (Functional Assessment of Chronic Illness Therapy Fatigue – Fatigue Subscore), and depression and anxiety (Hospital Anxiety and Depression Scale). Disease severity was assessed via file review through an independent gastroenterologist rating (Harvey–Bradshaw Index). Results: There were 67 responses. Depression, as measured by the Hospital Anxiety and Depression Scale, was found to be highly correlated with fatigue (Functional Assessment of Chronic Illness Therapy Fatigue – Fatigue Subscore). Anxiety, insecure attachment, disease severity and female gender were moderately correlated with fatigue. In a hierarchical regression model, depression and female gender emerged as significant predictors of variance in fatigue scores. Conclusions: Depression was the strongest predictor of variance in fatigue scores. Gender as a cause of fatigue in inflammatory bowel disease requires further exploration. Attachment style, however, may still help clinicians to conceptualise help-seeking behaviour and clinician-patient relationships in medically unexplained symptoms.

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Out of Sight, Out of Mind: The Limitations of the Hospital Anxiety and Depression Scale in Inflammatory Bowel Disease

Inflammatory Bowel Diseases ◽

10.1093/ibd/izz034 ◽

2019 ◽

Vol 25 (8) ◽

pp. e100-e100 ◽

Cited By ~ 1

Author(s):

Calum D Moulton ◽

Christopher W P Hopkins ◽

Zahra Mohamedali ◽

Nick Powell

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Depression Scale ◽

Anxiety And Depression ◽

Hospital Anxiety ◽

Inflammatory Bowel

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Hospital Anxiety and Depression Scale (HADS): Validation in Mexican patients with inflammatory bowel disease

Gastroenterología y Hepatología (English Edition) ◽

10.1016/j.gastre.2018.08.009 ◽

2018 ◽

Vol 41 (8) ◽

pp. 477-482

Author(s):

Jesús K. Yamamoto-Furusho ◽

Andrea Sarmiento-Aguilar ◽

Mario García-Alanis ◽

Luis Enrique Gómez-García ◽

Joel Toledo-Mauriño ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Depression Scale ◽

Anxiety And Depression ◽

Hospital Anxiety ◽

Inflammatory Bowel ◽

Mexican Patients

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INFLAMMATORY BOWEL DISEASE: IMPACT ON SCORES OF QUALITY OF LIFE, DEPRESSION AND ANXIETY IN PATIENTS ATTENDING A TERTIARY CARE CENTER IN BRAZIL

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201800000-54 ◽

2018 ◽

Vol 55 (3) ◽

pp. 202-207 ◽

Cited By ~ 5

Author(s):

Raquel Pellizzari CALIXTO ◽

Cristina FLORES ◽

Carlos Fernando FRANCESCONI

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Depression Scale ◽

Anxiety And Depression ◽

Hospital Anxiety ◽

Inflammatory Bowel Disease Questionnaire ◽

Inflammatory Bowel ◽

Disease Questionnaire

ABSTRACT BACKGROUND: Inflammatory bowel disease frequently affects patients at working age, compromising their quality of life in several levels: physical, psychological, familial and social. Few studies have evaluated the impact of Inflammatory bowel disease on quality of life, anxiety and depression in Brazilian patients. OBJECTIVE: Evaluate quality of life and its correlation with psychological aspects of patients with inflammatory bowel disease through the Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale. METHODS: Cross-sectional study; Inflammatory Bowel Disease Questionnaire, Short Form-36 and Hospital Anxiety and Depression Scale were applied to consecutive outpatients in a tertiary referral center for inflammatory bowel disease. Harvey-Bradshaw Index and Truelove scores were used to evaluate Crohn’s disease and ulcerative colitis activity. Sample calculation: 113 patients for a significance level of 5%, power of 90% and a correlation coefficient of at least 0.3 between scales. Statistical analysis: Student-t test, Pearson and Spearman correlations. RESULTS: One hundred twenty patients participated in the study; mean age: 41.7 years; female: 58.3%; Crohn’s Disease: 69 patients. No low scores for quality of life were found across the four Inflammatory Bowel Disease Questionnaire domains; the Short Form-36 showed low scores in physical limitations (47.2±42.4) and emotional aspects (49.8±43.4); Hospital Anxiety and Depression Scale score presented a mean of 9.5±2.7 for anxiety and 8.7±2.0 for depression. Quality of life was decreased and Hospital Anxiety and Depression Scale did show increased indices of anxiety and depression, in both diseases only when clinically active. CONCLUSION: Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale showed that outpatients of a tertiary care center for inflammatory bowel disease in Brazil presented good quality of life. The worst quality of life was associated with the intensity of the disease activity.

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P143 Depression and anxiety symptoms among patients with early inflammatory bowel disease during and after COVID-19 lockdown

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjab076.270 ◽

2021 ◽

Vol 15 (Supplement_1) ◽

pp. S228-S228

Author(s):

L Sempere Robles ◽

P Bernabeu ◽

J Cameo ◽

A Gutiérrez ◽

G García ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Activity Index ◽

Psychological Impact ◽

Previous History ◽

Depression Scale ◽

Anxiety And Depression ◽

Depression Symptoms ◽

Female Sex ◽

Inflammatory Bowel

Abstract Background Patients with inflammatory bowel disease (IBD) are vulnerable to some psychological disorders. Here we describe the psychological impact of a COVID-19 pandemic lockdown in patients with IBD. Methods This multicenter prospective cohort study included 145 patients recently diagnosed with IBD. Data on clinical and demographic characteristics, anxiety and depression (Hospital Anxiety and Depression Scale), and IBD activity (the Modified Harvey Bradshaw Index for CD and Simple Clinical Colitis Activity Index for CU) were collected in two telephone surveys, during and after the first COVID-19 lockdown in Spain. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results During lockdown, 33.1% and 24.1% scored high on the anxiety and depression scales, respectively. Independent factors related to anxiety (all values ORs; 95% CIs) during lockdown were female sex (2; 1.2–5.4) and IBD activity (4.3; 1.8–10.4). Factors related to depression were comorbidity (3.3; 1.1–9.8), IBD activity (6; 1.9–18.1), use of biologics (2.9; 1.1–7.6), and living alone or with one person (3.1; 1.2–8.2). After lockdown, anxiety and depression symptoms showed significant improvement, with 24.8% and 15.2% having high scores for anxiety and depression, respectively. Factors related to post-lockdown anxiety were female sex (2.5; 1.01–6.3), Crohn’s disease (3.3; 1.3–8.5), and active IBD (4.1; 1.2–13.7). Factors associated with depression were previous history of mood and/or anxiety disorders (6.3; 1.6–24.9), active IBD (7.5; 2.1–26.8), and steroid use (6.4; 1.4–29). Conclusion Lockdown during the COVID-19 pandemic had a significant psychological impact in patients with IBD. Disease activity was related to the presence of anxiety and depression symptoms during and after lockdown.

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P565 Illness perception as a clinical tool to detect mood disturbances (anxiety or depression) in inflammatory bowel disease patients

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjab076.686 ◽

2021 ◽

Vol 15 (Supplement_1) ◽

pp. S526-S526

Author(s):

M L De Castro Parga ◽

D Pereyra ◽

L Sanromán ◽

M Figueira ◽

V Hernández ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Illness Perception ◽

Depression Scale ◽

Tertiary Hospital ◽

Anxiety And Depression ◽

Clinical Tool ◽

Illness Perception Questionnaire ◽

Ethical Approval ◽

Inflammatory Bowel

Abstract Background In patients suffering from inflammatory bowel disease (IBD), a prevalence of anxiety and/or depression of 30–35% has been reported in phases of clinical inactivity, reaching up to 60–80% in the flare-ups. Moreover, the presence of psychological comorbidity is now considered to complicate the course of IBD. Our aim was to evaluate the relationship between mood disturbances and individual illness perception. Methods Patients attending our tertiary hospital IBD outpatient clinic were enrolled. They filled the “Hospital anxiety and depression scale” (HADS) and the “Brief illness perception questionnaire” (BIPQ). Sociodemographic characteristics, phenotype and clinical course of IBD were reviewed as well. Ethical approval of the study was obtained. Results A total of 201 patients were analyzed: male 102 (50.7%) female 99 (47.3%), UC 113 (56.2%), CD 88 (43.8%). The HADS prevalence of psychological pathology was 24%, (22% anxiety, 6.9% depression), and 17% patients previously were on mood medications. There were no differences between CU and EC, although EC patients tended to show more anxiety. Women had a higher prevalence of anxiety (29% vs 15.6%) and depression (9.6% vs 4.7%) than men (p=0.03 and p=0.009). Anxiety was also associated with previous IBD hospitalization (p=0.005), and depression with living alone (p=0.007). The BIPQ dimensions: consequences, concern and emotional response were statistically associated with the presence of psychological pathology, anxiety and depression (p=0.0005 each). Conclusion Mood disturbances are frequently found in IBD patients, especially among females. A negative individual illness perception of the consequences and emotions related to IBD seems to correlated strongly with the presence of anxiety and/ or depression in these patients.

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Depression and Anxiety Disorders Impact in the Quality of Life of Patients with Inflammatory Bowel Disease

Psychiatry Journal ◽

10.1155/2021/5540786 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Jesús K. Yamamoto-Furusho ◽

Katya E. Bozada Gutiérrez ◽

Andrea Sarmiento-Aguilar ◽

Ana Fresán-Orellana ◽

Perla Arguelles-Castro ◽

...

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Disease ◽

Sensitivity And Specificity ◽

Bowel Disease ◽

Depression Scale ◽

Negative Influence ◽

Anxiety And Depression ◽

Inflammatory Bowel ◽

Axis I

Objective. Anxiety and depression have a negative influence in the quality of life. The aim of the study was to determinate the levels of sensitivity and specificity of the Anxiety and Hospital Depression Scale (HADS) and compare the quality of life in patients with inflammatory bowel disease (IBD) and depression or anxiety. Methods. This study included 104 patients with diagnosis of IBD. Each patient received psychiatric intervention with SCID-I (Structured Clinical Interview for DSMIV Axis I Disorders) instrument as a gold standard to stablish the cut-off points of HADS. Quality of life was also evaluated with IBDQ-32. Demographic and clinical variables were collected. Results. Most of the patients reported a high quality of life (73.1%, n = 76 ), while 25.0% ( n = 26 ) express a moderate quality of life. The ROC curves for both psychiatric entities showed an adequate discriminative capacity of the HADS-anxiety dimension ( AUC = 0.84 , 95 % CI = 0.76 -0.92) with a limited discriminability of the HADS-depression dimension ( AUC = 0.58 , 95 % CI = 0.46 -0.70) using the proposed scoring of 8 as a cut-off point. Conclusions. Anxiety and depression impact negatively in the quality of life in Mexican patients with IBD. The Mexican version of HADS had acceptable internal consistency and external validity, with moderate sensitivity and specificity for clearly identifying clinical cases of anxiety and depression in patients with IBD.

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Fr503 FEAR OF COVID-19, ALONG WITH STRESS, ANXIETY, AND DEPRESSION, IS ASSOCIATED WITH BIOLOGIC USAGE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Gastroenterology ◽

10.1016/s0016-5085(21)01524-9 ◽

2021 ◽

Vol 160 (6) ◽

pp. S-335

Author(s):

Rishabh Shah ◽

Anoushka Dua ◽

Bruce D. Naliboff ◽

Priyam V. Tripathi ◽

Robert Mocharla ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Anxiety And Depression ◽

Inflammatory Bowel

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Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2017/6496727 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 50

Author(s):

Glynis Byrne ◽

Greg Rosenfeld ◽

Yvette Leung ◽

Hong Qian ◽

Julia Raudzus ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Multivariable Analysis ◽

Significant Proportion ◽

Mental Illnesses ◽

Self Report ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Psychiatric Interview ◽

Inflammatory Bowel

Background. Inflammatory bowel disease (IBD) patients are not routinely screened for depression and anxiety despite knowledge of an increased prevalence in people with chronic disease and negative effects on quality of life. Methods. Prevalence of anxiety and depression was assessed in IBD outpatients through retrospective chart review. The presence of anxiety and/or depression was determined using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 self-report questionnaires or by diagnosis through psychiatric interview. Patient demographics, disease characteristics, and medication information were also collected. Multivariable analysis was used to determine associations between patient factors and depression and anxiety. Results. 327 patient charts were reviewed. Rates of depression and anxiety were found to be 25.8% and 21.2%, with 30.3% of patients suffering from depression and/or anxiety. Disease activity was found to be significantly associated with depression and/or anxiety (p=0.01). Females were more likely to have anxiety (p=0.01). Conclusion. A significant proportion of IBD patients suffer from depression and/or anxiety. The rates of these mental illnesses would justify screening and referral for psychiatric treatment in clinics treating this population. Patients with active disease are particularly at risk for anxiety and depression.

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