Indomethacin-Induced Colonic Ulceration and Bleeding

1994 ◽  
Vol 28 (7-8) ◽  
pp. 883-885 ◽  
Author(s):  
Ran Oren ◽  
Moshe Ligumsky
Keyword(s):  
Drug Class ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Gi Tract ◽  
Short Term ◽  
Upper Gi ◽  
Case Summary ◽  
Colonic Ulceration ◽  
Small Intestinal ◽  
A Prospective Study

OBJECTIVE: To report a case of nonsteroidal antiinflammatory drug (NSAID)-induced lower gastrointestinal (GI) bleeding. CASE SUMMARY: A patient in whom short-term ingestion of indomethacin was associated with colonic ulceration and significant gastrointestinal bleeding is described. DISCUSSION: The bleeding ulceration of the ascending colon, associated in our patient with short-term indomethacin intake, confirms previous reports of the drug's deleterious effect on the lower GI tract. The incidence of NSAID injury of the small intestinal colon may be higher than that previously reported. CONCLUSIONS: A prospective study of NSAID users could assess the magnitude of lower GI lesions, concomitant with upper GI evaluation, and help determine limitations in the use of this drug class.

Strength and Sterility of Stock and Diluted Carprofen Over Time

2021 ◽  
Author(s):  
Jiajie J Xu ◽  
Deanna M Renner ◽  
Patrick A Lester
Keyword(s):  
Laboratory Animal ◽  
Room Temperature ◽  
Companion Animals ◽  
Antiinflammatory Drug ◽  
Storage Conditions ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Laboratory Animals ◽  
Short Term ◽  
Laboratory Rodents ◽  
Over Time

Carprofen, a nonsteroidal antiinflammatory drug, is a commonly used analgesic for laboratory animals. The manufacturerlabeling indicates the stock bottle may be stored and used for up to 28 d under refrigeration. However, institutional guidelines may vary in how long diluted carprofen solutions can be stored before they must be discarded. When administered to laboratory rodents, small volumes of the stock solution are diluted to provide accurate dosing and ease of administration. Because carprofen is formulated for use in companion animals (for example, dogs) and comes in larger volume multidose vials, the majority of carprofen at our institution is discarded before it can be used. In this study, we evaluated the amount of target ingredient present (strength), sterility, and endotoxin levels of both stock and diluted carprofen when stored in a variety of containers and at multiple temperature settings for up to 180 d, mimicking facets of typical use in laboratory animal research and medicine. We demonstrated that when refrigerated and stored in sterile vials, stock and diluted carprofen can be kept and used for up to 180 d while retaining strength and sterility. For short-term use, diluted carprofen can also be stored for up to 60 d at room temperature in conical tubes. These results will help establish scientifically justified storage conditions for carprofen to ensure that these agents remain appropriately potent and sterile for therapeutic use in laboratory animals.

Short-term and long-term benefits of endoscopic hemoclip application for Dieulafoy's lesion in the upper GI tract

2003 ◽  
Vol 57 (6) ◽  
pp. 653-656 ◽  
Author(s):  
Yasuharu Yamaguchi ◽  
Taro Yamato ◽  
Naoya Katsumi ◽  
Yasuyuki Imao ◽  
Kei Aoki ◽  
...  
Keyword(s):  
Gi Tract ◽  
Short Term ◽  
Dieulafoy’S Lesion ◽  
Upper Gi ◽  
Upper Gi Tract

Necrotizing Fasciitis Associated with Nonsteroidal Antiinflammatory Drug Use

1998 ◽  
Vol 14 (2) ◽  
pp. 58-62 ◽  
Author(s):  
Michael P Rivey ◽  
Douglas R Allington ◽  
Amanda L Henry Dunham
Keyword(s):  
Necrotizing Fasciitis ◽  
Clinical Course ◽  
Causative Factor ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Antiinflammatory Drugs ◽  
Over The Counter ◽  
Medical Disorder ◽  
Case Summary

Objective: To describe a case of necrotizing fasciitis (NF) that occurred following minor clean surgery in a seemingly otherwise healthy man who was taking over-the-counter (OTC) ibuprofen 200 mg and aspirin 325 mg before surgery. Case Summary: A 71-year-old white man underwent an uncomplicated laparoscopic cholecystectomy. His only medical disorder prior to surgery was osteoarthritis, for which he took OTC-strength ibuprofen; his only other regular medication was one aspirin 325-mg tablet daily for prevention of cardiac disease. Within 48 hours of the surgery, the onset of NF was apparent, and extensive tissue excision and debridement was required 1 week after the operation. All nonsteroidal antiinflammatory drugs (NSAIDs) were withheld. The patient survived a complicated clinical course over the next month. Discussion: A review of proposed risk factors for the development of NF in the patient indicated surgery and NSAID use. Analysis of the probability of NSAID use as a causative factor for the adverse reaction of NF suggests a possible role. This case suggests that NSAID use in lower OTC dosages may contribute to the onset or course of NF. The case report adds to existing literature suggesting an association between NSAID use and the development or course of NF. Conclusions: NSAIDs are widely used drugs, and any association as a causative or provocative factor for NF is a rare finding. However, practitioners should be aware of the proposed association.

Clinicopathological features of nonsteroidal antiinflammatory drug-induced small intestinal strictures

1988 ◽  
Vol 94 (4) ◽  
pp. 1070-1074 ◽  
Author(s):  
I. Bjarnason ◽  
A.B. Price ◽  
G. Zanelli ◽  
P. Smethurst ◽  
M. Burke ◽  
...  
Keyword(s):  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Clinicopathological Features ◽  
Drug Induced ◽  
Small Intestinal

scholarly journals Exploring Mucin as Adjunct to Phage Therapy

2021 ◽  
Vol 9 (3) ◽  
pp. 509
Author(s):  
Amanda Carroll-Portillo ◽  
Henry C. Lin
Keyword(s):  
Pathogenic Bacteria ◽  
Structural Changes ◽  
Phage Therapy ◽  
Bacterial Species ◽  
Gi Tract ◽  
Beneficial Bacteria ◽  
Phage Cocktail ◽  
Small Intestinal ◽  
Gastrointestinal Dysbiosis

Conventional phage therapy using bacteriophages (phages) for specific targeting of pathogenic bacteria is not always useful as a therapeutic for gastrointestinal (GI) dysfunction. Complex dysbiotic GI disorders such as small intestinal bowel overgrowth (SIBO), ulcerative colitis (UC), or Crohn’s disease (CD) are even more difficult to treat as these conditions have shifts in multiple populations of bacteria within the microbiome. Such community-level structural changes in the gut microbiota may require an alternative to conventional phage therapy such as fecal virome transfer or a phage cocktail capable of targeting multiple bacterial species. Additionally, manipulation of the GI microenvironment may enhance beneficial bacteria–phage interactions during treatment. Mucin, produced along the entire length of the GI tract to protect the underlying mucosa, is a prominent contributor to the GI microenvironment and may facilitate bacteria–phage interactions in multiple ways, potentially serving as an adjunct during phage therapy. In this review, we will describe what is known about the role of mucin within the GI tract and how its facilitation of bacteria–phage interactions should be considered in any effort directed at optimizing effectiveness of a phage therapy for gastrointestinal dysbiosis.

scholarly journals Direct visualization of drug behaviors in the upper GI tract via magnetically controlled capsule endoscopy

VideoGIE ◽  
2021 ◽  
Author(s):  
Yuan-Chen Wang ◽  
Jun Pan ◽  
Bin Jiang ◽  
Yang-Yang Qian ◽  
Xiao-Ou Qiu ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Direct Visualization ◽  
Gi Tract ◽  
Upper Gi ◽  
Upper Gi Tract
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