A Sclerosing Perineurioma With Collagen Rosette Formation: Benign Mimic of Low-Grade Fibromyxoid Sarcoma

2017 ◽  
Vol 26 (2) ◽  
pp. 145-147 ◽  
Author(s):  
David Creytens ◽  
Liesbeth Ferdinande ◽  
Jo Van Dorpe
Keyword(s):  
Gold Standard ◽  
Ring Finger ◽  
Metastatic Potential ◽  
Rosette Formation ◽  
Specific Marker ◽  
Low Grade ◽  
Fusion Genes ◽  
Current Case ◽  
Fibromyxoid Sarcoma ◽  
Sclerosing Perineurioma

We report the case of a sclerosing perineurioma with conspicious collagen rosette formation in a 20-year-old male presenting with a firm, painless nodule on the palmar side of his right ring finger. The main differential diagnosis is a low-grade fibromyxoid sarcoma. The distinction between these entities is important because low-grade fibromyxoid sarcoma has a metastatic potential, while, as a rule, perineuriomas are benign. The presence of collagen rosettes in this current case makes this distinction even more difficult given that approximately 30% of low-grade fibromyxoid sarcoma cases show the focal presence of collagen rosettes. The demonstration of the characteristic t(7;16), t(11;16) or t(11;22) translocations (resulting in the FUS-CREB3L2, FUS-CREB3L1 or EWSR1-CREB3L1 fusion genes, respectively) or immunoreactivity for MUC4, a recently described sensitive and specific marker for low-grade fibromyxoid sarcoma, remain the gold standard in the diagnosis of low-grade fibromyxoid sarcoma, differentiating it from perineurioma. This case is, to our knowledge, the first report on collagen rosettes in sclerosing perineurioma, extremely well mimicking low-grade fibromyxoid sarcoma, and further expanding the morphological spectrum of this rare subtype of perineurioma.

MUC4 Is a Highly Sensitive and Specific Marker for Low-grade Fibromyxoid Sarcoma

2011 ◽  
Vol 35 (5) ◽  
pp. 733-741 ◽  
Author(s):  
Leona A. Doyle ◽  
Emely Möller ◽  
Paola Dal Cin ◽  
Christopher D.M. Fletcher ◽  
Fredrik Mertens ◽  
...  
Keyword(s):  
Specific Marker ◽  
Low Grade ◽  
Highly Sensitive ◽  
Fibromyxoid Sarcoma

scholarly journals Radiation-Induced Low Grade Fibromyxoid Sarcoma of the Larynx: a Case Report and Literature Review

Folia Medica ◽  
2021 ◽  
Vol 63 (3) ◽  
pp. 433-437
Author(s):  
Dariya Chivchibashi ◽  
Pavel Pavlov ◽  
Maria Tzaneva ◽  
Nikolay Sapundzhiev ◽  
Georgi Davidov
Keyword(s):  
Case Report ◽  
Latency Period ◽  
Metastatic Potential ◽  
Low Grade ◽  
Imaging Evaluation ◽  
First Case ◽  
Fibromyxoid Sarcoma ◽  
History Of ◽  
Radiation Induced ◽  
Causes And Risk Factors

Low grade fibromyxoid sarcoma (LGFMS) is an uncommon variant of fibrosarcoma with high risk of local recurrence, immense metastatic potential and frequently protracted period between tumour presentation and metastasis. This unusual malignancy rarely affects the region of the head and neck which makes cases of laryngeal LGFMS extremely infrequent. To date, LGFMS of the larynx has been scatteredly mentioned in the literature. Neither incidence nor causes and risk factors for laryngeal LGFMS have been clarified so far. To the authors’ knowledge, this is the first case report that discusses the clinical course, imaging diagnosis, histopathological evaluation and surgical approach to radiation-induced laryngeal LGFMS.We present a case of a 70-year-old man who developed a LGFMS after previous radiotherapy (RT) for squamous cell carcinoma (SCC) of the larynx. The latency period between the time of radiation exposure and the diagnosis of LGFMS was twenty-seven months. After re-confirming the diagnosis with second biopsy and extensive imaging evaluation the patient was subjected to an open partial resection of the larynx. Owing to the rarity of the tumour, there is no established protocol with follow-up recommendations.This case highlights the importance of considering the RT history of the patient in order to monitor radiotherapy-related complications, including the occurrence of LGFMS.

Imaging findings of thoracic low-grade fibromyxoid sarcoma: report of three cases

2009 ◽  
Vol 27 (9) ◽  
pp. 375-380 ◽  
Author(s):  
Eriko Maeda ◽  
Satoshi Ohta ◽  
Takeyuki Watadani ◽  
Akiteru Goto ◽  
Atsushi Nakajima ◽  
...  
Keyword(s):  
Low Grade ◽  
Imaging Findings ◽  
Fibromyxoid Sarcoma

Low-Grade Fibromyxoid Sarcoma: A Brief Review

2006 ◽  
Vol 130 (9) ◽  
pp. 1358-1360 ◽  
Author(s):  
Stephen E. Vernon ◽  
Pablo A. Bejarano
Keyword(s):  
Spindle Cell ◽  
Fusion Gene ◽  
Cytogenetic Abnormality ◽  
Low Grade ◽  
Deep Soft Tissue ◽  
Balanced Translocation ◽  
Linear Arrangement ◽  
Myxoid Stroma ◽  
Fibromyxoid Sarcoma ◽  
The Common

Abstract Low-grade fibromyxoid sarcomas are uncommon deep soft tissue neoplasms first described by Evans in 1987. They exhibit a deceptively benign appearance, with a whorled or linear arrangement of spindle-shaped cells showing few to absent mitoses. A characteristic, but not specific, feature is the presence of areas of myxoid stroma. Recurrences are common, and late metastases have been recorded. A closely related but morphologically distinct tumor, the so-called hyalinizing spindle cell tumor with giant rosettes, has also been described; both neoplasms share the same cytogenetic abnormality, a balanced translocation resulting in a FUS/CREB3L2 fusion gene. Because of similar clinical behavior and the common cytogenetic abnormality, some authors prefer to consider both lesions as a single entity within the spectrum of low-grade sarcomas.

scholarly journals A rare case of low-grade fibromyxoid sarcoma with ossification which was radiologically detected as apparent calcification and histopathologically proven

2018 ◽  
Vol 12 ◽  
pp. 24-28
Author(s):  
Yasuaki Tsuchida ◽  
Yoshitane Tsukamoto ◽  
Hiroyuki Futani ◽  
Shunsuke Kumanishi ◽  
Takahiro Watanabe ◽  
...  
Keyword(s):  
Rare Case ◽  
Low Grade ◽  
Fibromyxoid Sarcoma

scholarly journals MRI findings of low-grade fibromyxoid sarcoma: a case report and literature review

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Yali Yue ◽  
Yongkang Liu ◽  
Lina Song ◽  
Xiao Chen ◽  
Yaohui Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Low Grade ◽  
Mri Findings ◽  
Fibromyxoid Sarcoma

scholarly journals A Case of Low-grade Fibromyxoid Sarcoma of the Colon

2014 ◽  
Vol 64 (6) ◽  
pp. 375 ◽  
Author(s):  
Min Kim ◽  
Tae Jun Song ◽  
Seung Dae Kang ◽  
Jong Sik Kang ◽  
Jin Suk Kim ◽  
...  
Keyword(s):  
Low Grade ◽  
Fibromyxoid Sarcoma

scholarly journals Development and Validation of an Efficient MRI Radiomics Signature for Improving the Predictive Performance of 1p/19q Co-Deletion in Lower-Grade Gliomas

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5398
Author(s):  
Quang-Hien Kha ◽  
Viet-Huan Le ◽  
Truong Nguyen Khanh Hung ◽  
Nguyen Quoc Khanh Le
Keyword(s):  
Gold Standard ◽  
Binary Classification ◽  
Predictive Performance ◽  
Deletion Mutation ◽  
Gradient Boosting ◽  
Low Grade ◽  
Lower Grade ◽  
Chromosome 1P ◽  
Extreme Gradient Boosting ◽  
External Test

The prognosis and treatment plans for patients diagnosed with low-grade gliomas (LGGs) may significantly be improved if there is evidence of chromosome 1p/19q co-deletion mutation. Many studies proved that the codeletion status of 1p/19q enhances the sensitivity of the tumor to different types of therapeutics. However, the current clinical gold standard of detecting this chromosomal mutation remains invasive and poses implicit risks to patients. Radiomics features derived from medical images have been used as a new approach for non-invasive diagnosis and clinical decisions. This study proposed an eXtreme Gradient Boosting (XGBoost)-based model to predict the 1p/19q codeletion status in a binary classification task. We trained our model on the public database extracted from The Cancer Imaging Archive (TCIA), including 159 LGG patients with 1p/19q co-deletion mutation status. The XGBoost was the baseline algorithm, and we combined the SHapley Additive exPlanations (SHAP) analysis to select the seven most optimal radiomics features to build the final predictive model. Our final model achieved an accuracy of 87% and 82.8% on the training set and external test set, respectively. With seven wavelet radiomics features, our XGBoost-based model can identify the 1p/19q codeletion status in LGG-diagnosed patients for better management and address the drawbacks of invasive gold-standard tests in clinical practice.

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