Sinonasal Hamartomas: From Nasal Chondromesenchymal Hamartoma to Respiratory Epithelial Adenomatoid Hamartoma. Report of six Cases and Review of the Literature

2022 ◽  
pp. 106689692110642
Author(s):  
Rongying Li ◽  
Karan Saluja ◽  
Mei Lin ◽  
Zhihong Hu ◽  
Zhenjian Cai ◽  
...  
Keyword(s):  
Adult Patients ◽  
Review Of The Literature ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Seromucinous Hamartoma ◽  
Sinonasal Mass ◽  
Pathologic Features ◽  
Respiratory Epithelial ◽  
Mass Lesions ◽  
Cellular Components ◽  
Nasal Chondromesenchymal Hamartoma

Sinonasal hamartomas are uncommon lesions of nasal and sinus cavities. Based on indigenous cellular components and characteristic histologic features, they are further classified into four entities: respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma (SH), chondro-osseous and respiratory epithelial hamartoma (CORE), and nasal chondromesenchymal hamartoma (NCH). REAH, SH, and CORE are seen in adult patients, while NCH predominantly occurs in newborns and infants. Morphologically REAH and SH are composed of respiratory epithelium and seromucinous glands, CORE is related to REAH but with additional feature of chondroid and/or osseous tissue, and NCH is composed of chondroid and stromal elements but devoid of epithelial component. All four lesions can present as sinonasal mass lesions and with associated obstructive symptoms. Given the rarity of these lesions, diagnosis can be challenging, especially in unusual clinical scenario. In this study, we report six cases of sinonasal hamartoma, including one case of NCH, one case of CORE, two cases of SH, and two cases of REAH. All cases were from adult patients including four men and two women. We also review the literature of the clinical and pathologic features of these rare lesions.

scholarly journals Nasal Chondromesenchymal Hamartoma: Rare Case Report in an Elderly Patient and Brief Review of Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Kanish Mirchia ◽  
Rana Naous
Keyword(s):  
Rare Case ◽  
Unusual Case ◽  
English Literature ◽  
The Body ◽  
Review Of Literature ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Rare Case Report ◽  
The Right ◽  
Respiratory Epithelial ◽  
Nasal Chondromesenchymal Hamartoma

Hamartomas are considered a mixture of nonneoplastic tissue, which may be indigenous to a different location in the body. As such, they may be epithelial, mesenchymal, or mixed. In the sinonasal region, the following hamartomatous lesions are considered to lie on a spectrum and include respiratory epithelial adenomatoid hamartoma (REAH), chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH), and nasal chondromesenchymal hamartoma (NCMH). To our knowledge, less than 50 cases of sinonasal hamartomas have been reported in the English literature so far with NCMH being very rare and primarily a tumor in infancy, with only 2 cases reported in individuals older than 16 years of age. We report a highly unusual case of a NCMH in the right maxillary sinus of a 70-year-old female.

scholarly journals Non-resolving acute sinusitis due to nasal hamartoma: a case report

2021 ◽  
pp. 233
Author(s):  
◽  
Keyword(s):  
Case Report ◽  
Paranasal Sinuses ◽  
Conventional Treatment ◽  
Benign Lesion ◽  
Acute Sinusitis ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Mild Disease ◽  
Nasal Tumor ◽  
Respiratory Epithelial ◽  
Nasal Chondromesenchymal Hamartoma

The paranasal sinuses are closely related to vital structures, and therefore, rhinosinusitis may lead to various dangerous complications. Nasal chondromesenchymal hamartoma is a rare benign lesion of the sinonasal tract in children and adolescents. We report the case of a 15-year-old patient with antibiotic-refractory acute sinusitis in whom a nasal tumor was identified and histopathologically diagnosed as a hamartoma. Therefore, the tumor was removed surgically to alleviate the patient’s symptoms. This case highlights the necessity of investigating the underlying cause if conventional treatment fails to resolve a mild disease like acute sinusitis. To the best of our knowledge, this is the first reported case of a chondro-osseous respiratory epithelial adenomatoid hamartoma presenting with acute sinusitis.

Plasmablastic lymphoma with small lymphocytic lymphoma: Clinico-pathologic features, and review of the literature

2008 ◽  
Vol 49 (10) ◽  
pp. 1999-2002 ◽  
Author(s):  
Preetha Ramalingam ◽  
Asha Nayak-Kapoor ◽  
Michelle Reid-Nicholson ◽  
Jennifer Jones-Crawford ◽  
Celalettin Ustun
Keyword(s):  
Plasmablastic Lymphoma ◽  
Review Of The Literature ◽  
Small Lymphocytic Lymphoma ◽  
Pathologic Features

Melanocytic Lesions of the Conjunctiva

2010 ◽  
Vol 134 (12) ◽  
pp. 1785-1792 ◽  
Author(s):  
Artur Zembowicz ◽  
Rajni V. Mandal ◽  
Pitipol Choopong
Keyword(s):  
Personal Experience ◽  
State Of The Art ◽  
Data Sources ◽  
Clinical Aspects ◽  
Review Of The Literature ◽  
Melanocytic Lesions ◽  
Pathologic Features

Abstract Context—Melanocytic proliferations are among the most common neoplasms of the conjunctiva. They often represent challenging lesions for pathologists unfamiliar with unique histologic features of melanocytic proliferations in this location and with nomenclature used by ophthalmologists. Objective—To comprehensively review clinical aspects, pathologic features, and management of melanocytic proliferations of the conjunctiva. Data Sources—Review of the literature and personal experience of the authors. Conclusions—Classification, state of the art, and practical aspects of pathology of melanocytic proliferations of the conjunctiva are discussed.

scholarly journals Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis

2018 ◽  
Vol 102 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Helen Zieschang ◽  
Rainer Koch ◽  
Manfred P. Wirth ◽  
Michael Froehner
Keyword(s):  
Systematic Review ◽  
Urinary Bladder ◽  
Meta Analysis ◽  
Adult Patients ◽  
Review Of The Literature

scholarly journals Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy

2011 ◽  
Vol 135 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Joshua Anspach Hanson ◽  
Abiy B. Ambaye
Keyword(s):  
Granulosa Cell ◽  
Case Reports ◽  
Granulosa Cell Tumor ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Stromal Tumors ◽  
Granulosa Cell Tumors ◽  
Pathologic Features ◽  
Sex Cord Stromal Tumors

Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and the presence of gynecomastia do not, at present, predict benign versus malignant behavior.

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