Elevated Intestinal Inflammation in Preterm Infants With Signs and Symptoms of Gastroesophageal Reflux Disease

2021 ◽  
pp. 109980042098788
Author(s):  
Colleen E. Shelly ◽  
Evgenia J. Filatava ◽  
Julie Thai ◽  
Britt F. Pados ◽  
Sara E. Rostas ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Preterm Infants ◽  
Reflux Disease ◽  
Multivariate Regression ◽  
Intestinal Inflammation ◽  
Signs And Symptoms ◽  
Fecal Calprotectin ◽  
Fatty Acid Binding ◽  
Gastrointestinal Distress

Objectives: Reflux is common in infancy; however, persistent signs and symptoms of gastrointestinal distress are often attributed to gastroesophageal reflux disease (GERD). In this pilot study, we aimed to characterize associations between signs and symptoms of suspected GERD and noninvasive markers of intestinal inflammation in preterm infants. Methods: We reviewed Electronic Medical Record (EMR) data to identify clinical signs and symptoms among case patients (n = 16). Controls (n = 16) were matched on gestational age. Univariate and multivariate regression analyses were used to compare fecal calprotectin and urinary intestinal fatty acid binding protein (I-FABP) levels between cases and controls. Results: We found no differences in baseline characteristics between cases and controls. In the multivariate regression analysis controlling for the proportion of mother’s milk, cases had higher fecal calprotectin levels than controls, with no differences in I-FABP levels between cases and controls. Conclusion: Our findings suggest that preterm infants with signs and symptoms of GERD have higher levels of intestinal inflammation as indicated by fecal calprotectin compared to their controls. Further studies are needed to evaluate the role of intestinal inflammation in signs and symptoms of gastrointestinal distress and whether fecal calprotectin might have predictive value in diagnosing GERD.

Pharmacodynamics and Systemic Exposure of Esomeprazole in Preterm Infants and Term Neonates with Gastroesophageal Reflux Disease

2009 ◽  
Vol 155 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Taher Omari ◽  
Per Lundborg ◽  
Marie Sandström ◽  
Patrik Bondarov ◽  
Mia Fjellman ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Preterm Infants ◽  
Reflux Disease ◽  
Systemic Exposure ◽  
Term Neonates

High Frecuency of Gastroesophageal Reflux Disease in Symptomatic Preterm Infants

2016 ◽  
Vol 111 ◽  
pp. S454
Author(s):  
Mario Blancas ◽  
Monica Hidalgo ◽  
Ruben Martinez ◽  
Claudia Blanco ◽  
Alejandro Angeles ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Preterm Infants ◽  
Reflux Disease

scholarly journals Congenital Hernia of Morgagni - A Case Report

2015 ◽  
Vol 2 (1) ◽  
pp. 61
Author(s):  
Sagar Sonawane ◽  
M. K. Tolani ◽  
Ravindra Sonawane ◽  
Nilesh Ahire ◽  
Suhas Patil ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Case Report ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Congenital Heart ◽  
Signs And Symptoms ◽  
Recurrent Pneumonia ◽  
Congenital Hernia

Congenital Diaphragmatic Hernia of Morgagni occurs through the foramen of Morgagni, is rare in children. It is usually asymptomatic and detected accidentally. If symptomatic, then symptoms are variable and nonspecific making diagnosis difficult . Our patient presented with signs and symptoms suggestive of congenital heart disease, gastroesophageal reflux disease and recurrent pneumonia.

scholarly journals Demographics and Clinical and Endoscopic Characteristics of Patients with Helicobacter pylori Infection and Gastroesophageal Reflux Disease: A Case-Control Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Amir Mari ◽  
Naim Mahroum ◽  
Nicola Luigi Bragazzi ◽  
Mahran Shalaata ◽  
Tawfik Khoury ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Regression Analysis ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Urease Test ◽  
H Pylori

Background. The correlation between Helicobacter pylori (H. pylori) and gastroesophageal reflux disease (GERD) is complex. Some studies showed a protective role of H. pylori infection against GERD. This study was aimed at assessing the role of H. pylori infection in GERD utilizing a large cohort of patients diagnosed with GERD. Methods and Materials. All patients who underwent gastroscopy for an indication of GERD during the study period between 2015 and 2017 at the EMMS Nazareth Hospital were considered eligible for the study and therefore were included. H. pylori infection was determined by the rapid urease test or histology. Severity of esophagitis was assessed using the Los Angeles classification. Univariate analysis was performed to figure out differences between patients according to H. pylori infection status. Multivariate regression analysis was conducted to illustrate the predictors of positivity for H. pylori infection. Results. 2,508 GERD patients were included with a median age of 49.42±17.96 years. H. pylori infection was detected in 299 (11.9%) patients. GERD patients with H. pylori infection were found to be younger (48.83±17.42 years versus 44.57±17.69 years, p<0.001), have the tendency to smoke more (1406 (63.6%) versus 266 (89.0%), p<0.001), and use more proton pump inhibitors or PPIs (1314 (59.5%) versus 242 (80.9%), p<0.001). In multivariate regression analysis, age (OR 0.987, p<0.001), smoking status (OR 0.190, p<0.001), use of ASA/NSAIDs (OR 1.652, p=0.004), and use of statins (OR 0.499 (95%CI 0.295-0.846), p=0.010) were found significant among H. pylori-positive individuals. H. pylori-positive subjects have less severe esophagitis and more hiatus hernia. Conclusion. Patients with GERD and H. pylori infection were significantly younger, tended to smoke more, and used more PPIs and had significantly lower grades of esophagitis compared to noninfected ones.

GASTROESOPHAGEAL REFLUX DISEASE DIAGNOSIS AND TREATMENT

2020 ◽  
Vol 4 (12) ◽  
Author(s):  
Khaled Hassan
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Healthcare Providers ◽  
Signs And Symptoms ◽  
Disease Diagnosis ◽  
Infants And Children ◽  
Older Children ◽  
Esophageal Reflux ◽  
Early Management

It remains a challenge to diagnose and treat gastro-esophageal reflux (GER) and GER disease (GERD) in infants and children. Together with Embase, MEDLINE, and the Cochrane Database, the published guidelines and position papers were reviewed and summarized in order to suggest a realistic GER and GERD strategy and management for healthcare providers and to standardize and enhance the quality of care for infants and children. Two algorithms were developed for this purpose, 1 for infants <12 months of age and the other for older children. None of the signs and symptoms of GER and GERD are unique and there is no screening test or tool for a gold standard. As a first-line approach, nutritional management is recommended in babies, while for early management, a clinical trial with antacid medication is recommended in children. The aim of the realistic recommendations of this review is to optimize GER management in infants and older children and to minimize the number of investigations and the improper use of medication. Keywords: Gastro-esophageal reflux, Gastroesophageal reflux disease, Esophagitis, Endoscopy, Impedance, Proton pump inhibitors, pH.

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