Correlation between retrobulbar blood flow parameters and retinal nerve fiber, ganglion cell and inner plexus layer thickness in myopia

2021 ◽  
pp. 112067212199200
Author(s):  
Ewa M Grudzińska ◽  
Daniel Zaborski ◽  
Monika Modrzejewska
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Color Doppler ◽  
Resistance Index ◽  
Doppler Imaging ◽  
Flow Parameters ◽  
Retrobulbar Blood Flow ◽  
Retinal Nerve Fiber

Purpose: To assess the thickness of the retinal nerve fiber layer (RNFL), ganglion cell and inner plexus layer (GCIPL) and blood flow parameters in retrobulbar vessels, and to analyze correlations between these parameters in myopes. Methods: The study included forty myopic and 20 healthy eyes. Standard eye examination was supplemented with OCT of the optic nerve and macula (GCIPL, RNFL, RNFL in each quadrant and rim area of the optic nerve) and color Doppler imaging of retrobulbar arteries [peak systolic and end-diastolic velocities, pulsatile index and resistance index (RI) in the ophthalmic (OA), central retinal (CRA), nasal posterior ciliary and temporal posterior ciliary arteries]. Results: Significant correlations were found between blood flow parameters in the CRA, RNFL and GCIPL thickness, and axial length (AL) and spherical equivalent (SE). There were significant positive correlations between RNFL with PSV and EDV in the CRA and negative correlations between RNFL and RI in the CRA. GCIPL was positively correlated with PSV and EDV in the CRA. The decrease in RA was associated with reduced blood flow velocities in the CRA, TPCA and NPCA. Conclusion: The reduced retrobulbar blood flow in healthy young myopes is correlated with increasing AL and refractive value, and thinning of the RNFL and GCIPL. Reduction of the rim-area of the optic disc is associated with vascular and retinal circulatory disorders. These phenomena indicate the vascular basis of the described changes. To the best of our knowledge, this is the first study which correlates ocular circulation with retinal structure.

scholarly journals The Effect of Nebulized Dorzolamide/Timolol Fixed Combination Mist versus Drops on Retrobulbar Blood Flow and Intraocular Pressure in Glaucoma Patients

Medicina ◽  
2013 ◽  
Vol 49 (7) ◽  
pp. 48
Author(s):  
Ingrida Janulevičienė ◽  
Lina Šiaudvytytė ◽  
Rūta Baršauskaitė ◽  
Vaida Dilienė ◽  
Loreta Kuzmienė ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Fixed Combination ◽  
Color Doppler ◽  
Resistance Index ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Ocular Irritation ◽  
Ocular Side ◽  
Retrobulbar Blood Flow

Objective. The aim of this study was to evaluate intraocular pressure (IOP), retrobulbar blood flow (RBF), and ocular side effects after the application of topical dorzolamide/timolol fixed combination (DTFC) drops vs topical nebulized DTFC mist in patients with primary openangle glaucoma. Material and Methods. A total of 15 POAG patients were enrolled in a prospective study. Retrobulbar blood flow was measured in the ophthalmic (OA) and central retinal (CRA) arteries using color Doppler imaging. DTFC mist or drops were applied to the experimental eye, and it was examined after 15 and 60 minutes. DTFC mist was applied 6 times for 30 seconds using a misting device. Results. DTFC mist significantly increased peak-systolic (PSV) and end-diastolic (EDV) velocities after 15 and 60 minutes in both the arteries (OA: increase of 12.5% and 9.6% in PSV, P=0.01; increase of 25.8% and 23.1% in EDV, P=0.03; CRA: increase of 11.5% and 8.7% in PSV, increase of 32% and 21.6% in EDV, respectively, P<0.05). DTFC drops had a similar effect on PSV and EDV in the CRA after 15 and 60 minutes (increase of 8.1% and 9.6% in PSV; increase of 17.1% and 23% in EDV, respectively, P=0.03), but a significant effect on PSV and EDV in the OA was documented only after 15 minutes (increase of 9% and 21.4%, respectively, P=0.02). DTFC mist reduced the resistance index in the CRA after 15 and 60 minutes (decrease of 8.5% and 10.2%, respectively, P=0.04). Both methodologies showed a significant decrease in IOP after 15 and 60 minutes (P<0.05). All patients complained of ocular irritation after drop application, and 1 patient complained of general weakness after mist treatment. Conclusions. Nebulized DTFC mist significantly reduced IOP and increased blood flow in the OA and the CRA, causing no ocular irritation as compared with traditional DTFC drop methodology.

Clinical Research of Thyroid Imaging Reporting and Data System Classification Combined with Color-Doppler Blood-Flow Parameters in Diagnosis of Benign and Malignant Thyroid Nodules

2020 ◽  
Vol 10 (7) ◽  
pp. 1564-1569
Author(s):  
Hongzhu Wang ◽  
Da Yu ◽  
Kunzhong Bao
Keyword(s):  
Blood Flow ◽  
High Frequency ◽  
Thyroid Nodules ◽  
Color Doppler ◽  
Resistance Index ◽  
Data System ◽  
High Frequency Ultrasound ◽  
Thyroid Imaging ◽  
Flow Parameters ◽  
Frequency Ultrasound

In order to investigate the characteristics of high-frequency ultrasound for the patients with thyroid nodules (TN), and we use the Thyroid Imaging Reporting And Data System (TI-RADS) to classify all the TN. Combined TIRADS classification with the features of color Doppler ultrasound and Doppler blood flow parameters for each nodule, we tried to diagnose TN between benign and malignant nodules so as to provide clinical physicians a more appropriate method and decision-making strategy for patients with of TN by ultrasound findings. The pulse Doppler technique was used to measure the peak systolic velocity (PSV) and resistance index (RI) of the blood flow within the nodule or closely around. The final pathology results were compared with all the ultrasound test. The diagnostic coincidence rates for B&M-TN were statistically compared by single two-dimensional ultrasound or by single color Doppler flow imaging or by combined technique of both. It can be seen that the combination strategy can optimize the coincidence rate of clinical diagnosis of B&M-TN. Therefore, the differential diagnosis of TN by high-frequency ultrasound TI-RADS classification combined with color Doppler blood flow parameters deserves our attention and further study.

scholarly journals Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

2016 ◽  
Vol 19 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Verticchio Vercellin Alice C. ◽  
Carlo A. Cutolo ◽  
Carolina Dellafiore ◽  
Massimiliano Lava ◽  
Carmine Tinelli ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Healthy Subjects ◽  
Color Doppler ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Velocity Measurements ◽  
Retrobulbar Blood Flow

scholarly journals High-frequency sonography in the evaluation of nail psoriasis.

2016 ◽  
Vol 18 (3) ◽  
pp. 312 ◽  
Author(s):  
Mihaela Elena Marina ◽  
Carolina Botar Jid ◽  
Sorana Daniela Bolboaca ◽  
Corina Bocsa ◽  
Carmen Mihaela Mihu ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Frequency ◽  
Color Doppler ◽  
Plate Thickness ◽  
Power Doppler ◽  
Psoriasis Patient ◽  
Nail Plate ◽  
Resistance Index ◽  
Doppler Imaging ◽  
Nail Involvement

Aim: To evaluate the morphostructural aspects and nail vascularity in the nail unit of patients with psoriasis, and to evaluate whether there are differences among psoriatic patients with and without nail involvement. Material and methods: Nail plates and nail bed changes, nailfold vessel resistance index (NVRI), power and color Doppler blood flow appearances were investigated in 23 patients with moderate-to-severe psoriasis, with and without nail involvement, and compared to those of 11 healthy participants. Results: Ventral nail plate deposits were present only in psoriasis patients. Irregular or totally fused nail plates and increased nail plate thickness was frequently observed in psoriasis patients compared to controls. NVRI was increased in psoriatic patients’ nails compared to controls (0.62 vs. 0.57, p<0.0001). In the psoriasis patient group there was significant statistical difference in NVRI in patients with nail involvement compared to those without (0.66 vs. 0.55, p<0.0001). Conclusions: High-frequency gray scale sonography provides valuable information regarding morphostructural changes in nail unit structure in patients with psoriasis. Power Doppler imaging enables blood flow assessment in psoriasis nail induced changes.

scholarly journals Color Doppler imaging and measurements of intraovarian and intrauterine vascularization on basal ultrasound examination in spontaneous ovulatory and anovulatory cycles

2008 ◽  
Vol 65 (10) ◽  
pp. 743-750 ◽  
Author(s):  
Ranko Kutlesic ◽  
Mileva Milosavljevic ◽  
Predrag Vukomanovic ◽  
Milan Stefanovic
Keyword(s):  
Blood Flow ◽  
Flow Resistance ◽  
Ultrasound Examination ◽  
Clinical Investigation ◽  
Color Doppler ◽  
Resistance Index ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Lower Resistance ◽  
Pulsatile Index

Background/Aim. Any organs functioning directly depends on vascularization. It applies also to the uterus and ovary which go through changes of vascularization during a menstruation cycle. The aim of this investigation was to determine differences in intrauterine and ovarian stromal arterioral blood flow on basal ultrasound examination (day 2-4) between spontaneous ovulatory and anovulatory cycles. Methods. This prospective clinical investigation included 205 patients divided into two groups: with ovulatory and with anovulatory cycles. Results. Resistance to ovarian arterioral stromal blood flow was significantly lower in the patients with ovulatory cycles (pulsatile index - PI 0.97 ? 0.4 vs 1.93 ? 1.37; p = 0.001737; and (resistance index - RI 0.55 ? 0.12 vs 0.68 ? 0.14; p = 0.040033). There were no statistically significant differences in arcuate arterioral blood flow in the pateints with ovulatory and anovulatory cycles (PI 1.21 ? 0.34 vs 61 ? 0,61 p = 0.136161 and RI 0.64 ? 0.11 vs 0.74 ? 0.07; p = 0.136649). The patients with ovulatory cycles had lower uterine radial arterioral blood flow than the patients with anovulatory cycles (PI 1.001 ? 0.22 vs 1.61 ? 0.23 p = 0.007501 and RI 0.55 ? 0.08 vs 0.71 ? 0.12; p = 0,0460113). The patients with ovulatory cycles had lower subendometrial arterioral blood flow resistance (PI 0.69 ? 0.19 vs 1.385?0.09; p = 0.00622 and RI 0.44 ? 0.09 vs 0.65 ? 0.02; p = 0.027458). Conclusion. Color Doppler ultrasuond imaging and measurements of intrauterine and ovarian stromal arterioral blood flow on basal ultrasound examination (day 2-4), showed lower resistance to blood flow in ovulatory than in anovulatory cycles.

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