scholarly journals Doege–Potter Syndrome and Hypoglycemia associated with Solitary Fibrous Tumor of the Pleura: Two Case Reports

2020 ◽  
Vol 14 ◽  
pp. 117954842096475
Author(s):  
Liliana Fernández-Trujillo ◽  
Jhon E Bolaños ◽  
Carolina Álvarez ◽  
Julián Giraldo ◽  
Mauricio Velásquez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Solitary Fibrous Tumor ◽  
Incidental Finding ◽  
Case Reports ◽  
Tumor Resection ◽  
Insulin Like Growth Factor ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Single Mass ◽  
Fibrous Tumor

Solitary fibrous tumors of the pleura (SFTP) are rare mesenchymal neoplasms that originate from mesenchymal growth in the pleura, tend to be single tumors, usually have an indolent course and show nonspecific symptoms. SFTP can be often diagnosed from an incidental finding of a single mass in the thorax and should be confirmed by biopsy and immunohistochemistry. A minority of cases may present Doege–Potter syndrome (DPS, episodes of refractory hypoglycemia) associated with production of insulin-like growth factor 2 (IGF-2). Both SFTP and DPS are rare occurrences with less than 2000 cases reported worldwide. The curative treatment is tumor resection. Two cases of patients with DPS caused by SFTP are presented below.

Solitary fibrous tumor of the pleura as a rare cause of severe hypoglycemia: Doege-Potter syndrome

2020 ◽  
Vol 99 (2) ◽  
pp. 95-98
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Solitary Fibrous Tumor ◽  
Tumor Resection ◽  
Insulin Like Growth Factor ◽  
En Bloc ◽  
Solitary Fibrous Tumors ◽  
Factor Ii ◽  
Fibrous Tumor ◽  
Recurrent Hypoglycemia

Introduction: Doege-Potter syndrome is a rare syndrome characterized by hypo-insulinemic hypoglycemia. It is caused by excessive ectopic secretion of insulin-like growth factor II from a solitary fibrous tumors of intrapleural or extrapleural origin. Laboratory tests reveal low levels of C-peptide and insulin, on the contrary insulin-like growth factor II level is elevated, which is characteristic for Doege-Potter syndrome. Majority of solitary fibrous tumors present no symptomatology, recurrent hypoglycemia is relatively rare, but it may be the only clinical manifestation. The therapy is surgical, consisting of radical en-bloc tumor resection. Case report: Authors present a case report of a patient with recurrent hypoglycemia caused solely by solitary fibrous tumor. Hypoglycemia resolved immediately after surgical resection and there were no recurrences. Conclusion: Doege-Potter syndrome should be considered as the differential diagnosis in a patient with suspicion on thoracic malignancy if accompanied by features suggestive of hypoglycemia. Prolonged follow up is strongly advised because of the risk of disease recurrence, even in patients with benign solitary fibrous tumors of the pleura (SFTP).

scholarly journals An urological cause of hypoglycaemia: A case report of the Doege-Potter syndrome

2020 ◽  
Vol 92 (4) ◽  
Author(s):  
Nuno Ramos ◽  
Rodrigo Ramos ◽  
Celso Marialva ◽  
Eduardo Silva
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Solitary Fibrous Tumor ◽  
Paraneoplastic Syndrome ◽  
Insulin Like Growth Factor ◽  
Kidney Tumor ◽  
Ectopic Secretion ◽  
Factor Ii ◽  
Fibrous Tumor

The Doege-Potter syndrome is a rare paraneoplastic syndrome presenting with hypoglycaemia due to ectopic secretion of insulin-like growth factor II (IGF-II) from a solitary fibrous tumor. The underlying tumor can be benign or malignant and rarely present in extrapleural sites. We describe the case of a 83-year-old male diagnosed with a Doege-Potter syndrome due to a kidney tumor.

Solitary Fibrous Tumor of the Larynx: A Case Report and Review of the Literature

2006 ◽  
Vol 130 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Jorge E. Dotto ◽  
William Ahrens ◽  
David J. Lesnik ◽  
Diane Kowalski ◽  
Clarence Sasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Review Of The Literature ◽  
Solitary Fibrous Tumors ◽  
Subsequent Investigation ◽  
Mesenchymal Neoplasms ◽  
Fibrous Tumor

Abstract Solitary fibrous tumors are relatively rare mesenchymal neoplasms that were originally described as pleural- or peritoneal-based lesions. Although they were considered a form of mesothelioma, subsequent investigation failed to reveal mesothelial differentiation. Characterization of their histologic and immunohistochemical features, as well as identification in a multitude of nonmesothelial-based locations has further served to distinguish these lesions from the more diffuse and aggressive mesothelioma. Reports of solitary fibrous tumor in the larynx are extremely rare. We report a case of solitary fibrous tumor of the larynx in a 38-year-old man.

Extrapleural Solitary Fibrous Tumor of the Foot

2015 ◽  
Vol 105 (6) ◽  
pp. 557-559
Author(s):  
Charles A. Kean ◽  
Bridget R. Moore ◽  
Ashley M. Nettles ◽  
Richard P. Bui
Keyword(s):  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Complete Surgical Excision ◽  
Rare Manifestation ◽  
Painless Mass ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor ◽  
Male Veteran

Solitary fibrous tumors are uncommon mesenchymal neoplasms that were initially described as pleural tumors, but in recent years, numerous extrapleural sites have been reported. A solitary fibrous tumor is characterized as a circumscribed, painless mass with a patternless growth pattern, positive CD34 spindle-shaped cells, bcl-2, and dense keloidal collagen with areas of hypercellularity and hypocellularity. This case report describes a 55-year-old male veteran who presented with a rare manifestation of an extrapleural solitary fibrous tumor of the medial right hallux. Microscopic and immunohistochemical findings were consistent with the previously documented characteristics of solitary fibrous tumors. Complete surgical excision of the tumor is the treatment of choice.

Solitary fibrous tumor in the pelvis: induced hypoglycemia associated with insulin-like growth factor II

2015 ◽  
Vol 20 (2) ◽  
pp. 439-443 ◽  
Author(s):  
Seiichi Hosaka ◽  
Hirohisa Katagiri ◽  
Jyunji Wasa ◽  
Hideki Murata ◽  
Mitsuru Takahashi
Keyword(s):  
Growth Factor ◽  
Solitary Fibrous Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Fibrous Tumor
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