Myelin oligodendrocyte glycoprotein-antibody (MOG-IgG) associated disease with centrally located long spinal cord lesion in a 14-month old child

Myelin oligodendrocyte glycoprotein-antibodies (MOG-IgG) are associated with acquired inflammatory demyelinating syndromes, seen predominantly in children and young adults. The overlapping clinical and radiological features of the heterogenous spectrum of demyelinating central nervous system (CNS) diseases makes the detection of MOG-IgG antibodies important for prognosis and treatment decisions. Herein, we describe the occurrence of MOG-IgG associated disease presenting as acute disseminated encephalomyelitis (ADEM), with spinal MRI findings of centrally located long cord lesion in a 14-month old child.

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A case of ADEM with atypical MRI findings of a centrally-located long spinal cord lesion

Brain and Development ◽

10.1016/j.braindev.2011.06.010 ◽

2012 ◽

Vol 34 (5) ◽

pp. 380-383 ◽

Cited By ~ 4

Author(s):

Yukifumi Monden ◽

Takanori Yamagata ◽

Yuri Kuroiwa ◽

Toshiyuki Takahashi ◽

Masato Mori ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Lesion ◽

Mri Findings ◽

Cord Lesion

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Efficacy of fesoterodine fumarate in Neurogenic Detrusor Overactivity (NDO) due to Spinal Cord Lesion (SCL) or Multiple Sclerosis (MS) – A prospective study

European Urology ◽

10.1016/s0302-2838(21)00413-9 ◽

2021 ◽

Vol 79 ◽

pp. S25-S26

Author(s):

C. Konstantinidis ◽

M. Samarinas ◽

M. Tzitzika ◽

C. Thomas ◽

Z. Kratiras ◽

...

Keyword(s):

Multiple Sclerosis ◽

Spinal Cord ◽

Prospective Study ◽

Detrusor Overactivity ◽

Spinal Cord Lesion ◽

Neurogenic Detrusor Overactivity ◽

A Prospective Study ◽

Cord Lesion

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Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis

Journal of Neuroscience Methods ◽

10.1016/j.jneumeth.2016.01.013 ◽

2016 ◽

Vol 262 ◽

pp. 66-76 ◽

Cited By ~ 8

Author(s):

Robert van den Berg ◽

Jon D. Laman ◽

Marjan van Meurs ◽

Rogier Q. Hintzen ◽

Casper C. Hoogenraad

Keyword(s):

Spinal Cord ◽

Image Analysis ◽

Experimental Autoimmune Encephalomyelitis ◽

Motor Performance ◽

Spinal Cord Lesion ◽

Autoimmune Encephalomyelitis ◽

Cord Lesion ◽

Experimental Autoimmune

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Anti-amphiphysin antibody-positive paraneoplastic neurological syndrome with a longitudinally extensive spinal cord lesion of the dorsal column

Rinsho Shinkeigaku ◽

10.5692/clinicalneurol.54.572 ◽

2014 ◽

Vol 54 (7) ◽

pp. 572-576 ◽

Cited By ~ 1

Author(s):

Shuichiro Neshige ◽

Naoyuki Hara ◽

Shinichi Takeshima ◽

Hirotaka Iwaki ◽

Yutaka Shimoe ◽

...

Keyword(s):

Spinal Cord ◽

Paraneoplastic Neurological Syndrome ◽

Dorsal Column ◽

Spinal Cord Lesion ◽

Neurological Syndrome ◽

Cord Lesion

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Longitudinally extensive spinal cord lesion associated with intramedullary metastasis on MRI may represent pencil-shaped softening of the spinal cord

Rinsho Shinkeigaku ◽

10.5692/clinicalneurol.51.433 ◽

2011 ◽

Vol 51 (6) ◽

pp. 433-433

Author(s):

Takashi Kameyama

Keyword(s):

Spinal Cord ◽

Spinal Cord Lesion ◽

Intramedullary Metastasis ◽

Cord Lesion

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Cross-cultural adaptation of the spinal cord lesion-related coping strategies questionnaire for use in Iran

Injury ◽

10.1016/j.injury.2015.04.035 ◽

2015 ◽

Vol 46 (8) ◽

pp. 1539-1544 ◽

Cited By ~ 5

Author(s):

Mohsen Saffari ◽

Amir H. Pakpour ◽

Mohammad Yaghobidoot ◽

Faten Al Zaben ◽

Harold G. Koenige

Keyword(s):

Spinal Cord ◽

Coping Strategies ◽

Cultural Adaptation ◽

Spinal Cord Lesion ◽

Cross Cultural ◽

Cross Cultural Adaptation ◽

Cord Lesion

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The Temporal and Spatial Activation of Microglia in Fiber Tracts Undergoing Anterograde and Retrograde Degeneration Following Spinal Cord Lesion

Journal of Neurotrauma ◽

10.1089/neu.1995.12.209 ◽

1995 ◽

Vol 12 (2) ◽

pp. 209-222 ◽

Cited By ~ 82

Author(s):

MORIMICHI KOSHINAGA ◽

SCOTT R. WHITTEMORE

Keyword(s):

Spinal Cord ◽

Spinal Cord Lesion ◽

Retrograde Degeneration ◽

Fiber Tracts ◽

Temporal And Spatial ◽

Cord Lesion

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Reduction of Common Synaptic Drive to Ankle Dorsiflexor Motoneurons During Walking in Patients With Spinal Cord Lesion

Journal of Neurophysiology ◽

10.1152/jn.00082.2005 ◽

2005 ◽

Vol 94 (2) ◽

pp. 934-942 ◽

Cited By ~ 76

Author(s):

N. L. Hansen ◽

B. A. Conway ◽

D. M. Halliday ◽

S. Hansen ◽

H. S. Pyndt ◽

...

Keyword(s):

Spinal Cord ◽

Motor Unit ◽

Healthy Subjects ◽

Motor Units ◽

Central Peak ◽

Spinal Cord Lesion ◽

Short Term ◽

Physiological Markers ◽

Synaptic Drive ◽

Cord Lesion

It is possible to obtain information about the synaptic drive to motoneurons during walking by analyzing motor-unit coupling in the time and frequency domains. The purpose of the present study was to compare motor-unit coupling during walking in healthy subjects and patients with incomplete spinal cord lesion to obtain evidence of differences in the motoneuronal drive that result from the lesion. Such information is of importance for development of new strategies for gait restoration. Twenty patients with incomplete spinal cord lesion (SCL) participated in the study. Control experiments were performed in 11 healthy subjects. In all healthy subjects, short-term synchronization was evident in the discharge of tibialis anterior (TA) motor units during the swing phase of treadmill walking. This was identified from the presence of a narrow central peak in cumulant densities constructed from paired EMG recordings and from the presence of significant coherence between these signals in the 10- to 20-Hz band. Such indicators of short-term synchrony were either absent or very small in the patient group. The relationship between the amount of short-term synchrony and the magnitude of the 10- to 20-Hz coherence in the patients is discussed in relation to gait ability. It is suggested that supraspinal drive to the spinal cord is responsible for short-term synchrony and coherence in the 10- to 20-Hz frequency band during walking in healthy subjects. Absence or reduction of these features may serve as physiological markers of impaired supraspinal control of gait in SCL patients. Such markers could have diagnostic and prognostic value in relation to the recovery of locomotion in patients with central motor lesions.

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