scholarly journals Canadian Burden of Skin Disease From 1990 to 2017: Results From the Global Burden of Disease 2017 Study

2020 ◽  
Vol 24 (2) ◽  
pp. 161-173 ◽  
Author(s):  
Alanna C. Bridgman ◽  
Christina Fitzmaurice ◽  
Robert P. Dellavalle ◽  
Chante Karimkhani Aksut ◽  
Ayman Grada ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Skin Disease ◽  
Skin Diseases ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
High Morbidity ◽  
Uncertainty Interval ◽  
Disability Adjusted Life ◽  
Life Years

Background Skin diseases can have high morbidity that can be costly to society and individuals. To date, there has been no comprehensive assessment of the burden of skin disease in Canada. Objectives To evaluate the burden of 18 skin and subcutaneous diseases from 1990 to 2017 in Canada using the Global Burden of Disease (GBD) data. Methods The 2017 GBD study measures health loss from 359 diseases and injuries in 195 countries; we evaluated trends in population health in Canada from 1990 to 2017 using incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs). Data are presented as rates (per 100 000), counts, or percent change with the uncertainty interval in brackets. Results From 1990 to 2017 for all skin diseases, DALY rates increased by 8% to 971 per 100 000 (674-1319), YLD rates increased by 8% to 897 per 100 000 (616-1235), YLL rates increased by 4% to 74 per 100 000 (53-89), and death rates increased by 18% to 5 per 100 000 (3-6). DALY rates for melanoma increased by 2% to 54 per 100 000 (39-68), for keratinocyte carcinoma by 14% to 17 per 100 000 (16-19), and for skin and subcutaneous disease by 8% to 900 per 100 000 (619-1233). The observed over expected ratios were higher for skin and subcutaneous disease (1.37) and keratinocyte carcinoma (1.17) and were lower for melanoma (0.73). Conclusions The burden of skin disease has increased in Canada since 1990. These results can be used to guide health policy regarding skin disease in Canada.

scholarly journals Global Burden of Skin Disease Representation in the Literature (Preprint)

2021 ◽  
Author(s):  
Kayd J. Pulsipher ◽  
Mindy D. Szeto ◽  
Chandler W. Rundle ◽  
Colby L. Presley ◽  
Melissa R. Laughter ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Skin Disease ◽  
Skin Diseases ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Pubmed Search ◽  
Number Of Publications

BACKGROUND Through research efforts focused on skin diseases with the highest reported disability-adjusted life years, the global burden of skin disease may be reduced. OBJECTIVE This study evaluates the representation of dermatologic conditions comprising the highest disability-adjusted life years in dermatology literature to identify areas that could benefit from greater research focus. METHODS The top ten skin disorders according to their respective disability-adjusted life years according to the 2013 Global Burden of Disease were identified using previous studies. The top five dermatology journals ranked by 2019 h-index were also identified. A PubMed search of each journal was performed using individual skin disease terms. From 2015-2020, all indexed publications pertaining to each disease were recorded and compared to the total number of publications for each journal surveyed. RESULTS A total of 19,727 articles were published among the five journals over the span of 2015-2020. While only ranking as the 8th highest in disability-adjusted life years, melanoma had the highest representation in the literature (10.11% of total publications, n=1995). Melanoma was followed in representation by psoriasis (9.81%, n=1936) and dermatitis (9.77%, n=1927). These three conditions comprised a total of 29.51% of total publications, while the remaining seven skin conditions were represented by a combined 6.79% of total publications. CONCLUSIONS This research identifies gaps in the literature related to the top skin diseases contributing to the global burden of disease. Our study provides insight into future opportunities of focused research on less-studied skin diseases to potentially aid in reducing the global burden of skin disease.

The prevalence and burden of mental and substance use disorders in Australia: Findings from the Global Burden of Disease Study 2015

2018 ◽  
Vol 52 (5) ◽  
pp. 483-490 ◽  
Author(s):  
Liliana G Ciobanu ◽  
Alize J Ferrari ◽  
Holly E Erskine ◽  
Damian F Santomauro ◽  
Fiona J Charlson ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study ◽  
Years Lived With Disability

Objectives: Timely and accurate assessments of disease burden are essential for developing effective national health policies. We used the Global Burden of Disease Study 2015 to examine burden due to mental and substance use disorders in Australia. Methods: For each of the 20 mental and substance use disorders included in Global Burden of Disease Study 2015, systematic reviews of epidemiological data were conducted, and data modelled using a Bayesian meta-regression tool to produce prevalence estimates by age, sex, geography and year. Prevalence for each disorder was then combined with a disorder-specific disability weight to give years lived with disability, as a measure of non-fatal burden. Fatal burden was measured as years of life lost due to premature mortality which were calculated by combining the number of deaths due to a disorder with the life expectancy remaining at the time of death. Disability-adjusted life years were calculated by summing years lived with disability and years of life lost to give a measure of total burden. Uncertainty was calculated around all burden estimates. Results: Mental and substance use disorders were the leading cause of non-fatal burden in Australia in 2015, explaining 24.3% of total years lived with disability, and were the second leading cause of total burden, accounting for 14.6% of total disability-adjusted life years. There was no significant change in the age-standardised disability-adjusted life year rates for mental and substance use disorders from 1990 to 2015. Conclusion: Global Burden of Disease Study 2015 found that mental and substance use disorders were leading contributors to disease burden in Australia. Despite several decades of national reform, the burden of mental and substance use disorders remained largely unchanged between 1990 and 2015. To reduce this burden, effective population-level preventions strategies are required in addition to effective interventions of sufficient duration and coverage.

scholarly journals The disvalue of death in the global burden of disease

2017 ◽  
Vol 44 (3) ◽  
pp. 192-198 ◽  
Author(s):  
Carl Tollef Solberg ◽  
Ole Frithjof Norheim ◽  
Mathias Barra
Keyword(s):  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Loss Of Life ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Life Itself ◽  
Disease Study ◽  
Years Lived With Disability

In the Global Burden of Disease study, disease burden is measured as disability-adjusted life years (DALYs). The paramount assumption of the DALY is that it makes sense to aggregate years lived with disability (YLDs) and years of life lost (YLLs). However, this is not smooth sailing. Whereas morbidity (YLD) is something that happens to an individual, loss of life itself (YLL) occurs when that individual’s life has ended. YLLs quantify something that involves no experience and does not take place among living individuals. This casts doubt on whether the YLL is an individual burden at all. If not, then YLDs and YLLs are incommensurable. There are at least three responses to this problem, only one of which is tenable: a counterfactual account of harm. Taking this strategy necessitates a re-examination of how we count YLLs, particularly at the beginning of life.

scholarly journals Burden of Depressive and Anxiety Disorders in Nepal, 1990-2017: An Analysis of Global Burden of Disease Data

2021 ◽  
Author(s):  
Deepa Kumari Bhatta ◽  
Kreeti Budhathoki ◽  
Kiran Paudel ◽  
Shishir Paudel ◽  
Sujan Babu Marhatta ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Burden Of Disease ◽  
Depressive Disorders ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Uncertainty Interval ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Age And Sex ◽  
Incidence Prevalence

Objectives: This study aims to describe the burden of depressive and anxiety disorders in Nepal in terms of incidence, prevalence, YLDs, and DALYs by age and sex. Design: An ecological study on disease burden. Methods: We used the publicly available Global Burden of Disease (GBD) data from 1990 to 2017. The age and sex-specific incidence, prevalence rate, Years Lived with Disability (YLDs), and Disability Adjusted Life Years (DALYs) were examined among per 100,000 populations. Results: Females had a higher prevalence of depressive 4094.4 (95% uncertainty interval [UI]: 3761.9-4470.3 per 100,000) and anxiety 4496.8 (95% UI: 4171.9-4837.9 per 100,000) disorders. The prevalence of major depressive disorders was comparatively higher in females (2766.7) than males (1822.9). Females also had higher YLDs for both depressive and anxiety disorders. In 2017, higher DALYs of anxiety disorder were found in the females of 45-49 years (630.1). Childhood sexual abuse was found to be the main risk factor for depressive disorder, contributing to 32.5 DALYs in both sexes. Bullying, victimization had contributed to 26.7 DALYs of anxiety. Conclusions: The high burden of disorders in females would support in identifying major mental health challenges in Nepal and develop plans and various preventive, curative, and rehabilitative strategies.

scholarly journals The global burden of falls: global, regional and national estimates of morbidity and mortality from the Global Burden of Disease Study 2017

2020 ◽  
Vol 26 (Supp 1) ◽  
pp. i3-i11 ◽  
Author(s):  
Spencer L James ◽  
Lydia R Lucchesi ◽  
Catherine Bisignano ◽  
Chris D Castle ◽  
Zachary V Dingels ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Past Research ◽  
Morbidity And Mortality ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Bodily Injury ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study

BackgroundFalls can lead to severe health loss including death. Past research has shown that falls are an important cause of death and disability worldwide. The Global Burden of Disease Study 2017 (GBD 2017) provides a comprehensive assessment of morbidity and mortality from falls.MethodsEstimates for mortality, years of life lost (YLLs), incidence, prevalence, years lived with disability (YLDs) and disability-adjusted life years (DALYs) were produced for 195 countries and territories from 1990 to 2017 for all ages using the GBD 2017 framework. Distributions of the bodily injury (eg, hip fracture) were estimated using hospital records.ResultsGlobally, the age-standardised incidence of falls was 2238 (1990–2532) per 100 000 in 2017, representing a decline of 3.7% (7.4 to 0.3) from 1990 to 2017. Age-standardised prevalence was 5186 (4622–5849) per 100 000 in 2017, representing a decline of 6.5% (7.6 to 5.4) from 1990 to 2017. Age-standardised mortality rate was 9.2 (8.5–9.8) per 100 000 which equated to 695 771 (644 927–741 720) deaths in 2017. Globally, falls resulted in 16 688 088 (15 101 897–17 636 830) YLLs, 19 252 699 (13 725 429–26 140 433) YLDs and 35 940 787 (30 185 695–42 903 289) DALYs across all ages. The most common injury sustained by fall victims is fracture of patella, tibia or fibula, or ankle. Globally, age-specific YLD rates increased with age.ConclusionsThis study shows that the burden of falls is substantial. Investing in further research, fall prevention strategies and access to care is critical.

scholarly journals Morbidity and mortality associated with injuries: results of the Global Burden of Disease study in Brazil, 2008

2015 ◽  
Vol 31 (1) ◽  
pp. 121-136 ◽  
Author(s):  
Mônica Rodrigues Campos ◽  
Vanessa dos Reis von Doellinger ◽  
Luiz Villarinho Pereira Mendes ◽  
Maria de Fatima dos Santos Costa ◽  
Thiago Góes Pimentel ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Disability Adjusted Life ◽  
Life Years ◽  
External Causes ◽  
Disease Study

The aim of this study was to estimate the global burden of disease from external causes in 2008 in Brazil, based on DALYs (disability-adjusted life years). YLLs (years of life lost) were estimated according to the method proposed by Murray & Lopez (1996). Meanwhile, the method for estimating YLDs (years lived with disability) included methodological adjustments taking the Brazilian reality into account. The study showed a total of 195 DALYs per 100 thousand inhabitants, of which 19 DALYs were related to external causes. Among YLLs, 48% were from unintentional causes and 52% from intentional causes. Among YLDs, unintentional causes predominated, with 95%. The share of YLLs in DALYs was 90%. The cause with the highest proportion of YLLs was "homicide and violence" (43%), followed by "road traffic accidents" (31%). Falls accounted for the highest share of YLDs (36%). The sex ratio (male-to-female) was 4.8 for DALYs, and the predominant age bracket was 15-29 years. Since external causes are avoidable, the study provides potentially useful information for policymakers in public security and health.

scholarly journals The burden of skin diseases in India: Global Burden of Disease Study 2017

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
A Kavita ◽  
J. S. Thakur ◽  
Tarun Narang
Keyword(s):  
Burden Of Disease ◽  
Skin Disease ◽  
Skin Diseases ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Uncertainty Interval ◽  
Interactive Tool ◽  
Study Results ◽  
Disease Study ◽  
Years Lived With Disability

Background: The prevalence of skin diseases has increased over the last few decades, and they contribute to a significant burden on health-care systems across the world. Aims/Objective: This report looks at the burden of skin and subcutaneous diseases in terms of years lived with disability and agestandardised years lived with disability in India using the Global Burden of Disease Study results from 2017. Methods: Data were obtained from the Global Burden of Disease online interactive tool. Updated estimates of the world’s health for 359 diseases and injuries and 84 risk factors from 1990 to 2017 are available in this interactive tool. Results: Years lived with disability due to skin and subcutaneous diseases accounted for 4.02% of the total years lived with disability in India in 2017. There was an increase of 53.7% in all age standardised years lived with disability for all the skin and subcutaneous diseases from 1990 to 2017. Among skin and subcutaneous diseases, dermatitis contributed maximum years lived with disability (1.40 million; 95% uncertainty interval, 0.82–2.21) in 2017, followed by urticaria (1.02 million; 95% uncertainty interval, 0.06–1.44) with percentage increases of 48.9% and 45.7% respectively. Conclusion: The burden due to infectious skin diseases (e.g., scabies, fungal skin disease and bacterial skin disease) and non-infectious diseases (e.g., dermatitis, urticaria and psoriasis) has increased over the past three decades, however the age-standardised years lived with disability for leprosy, scabies, fungal infections, sexually transmitted infections and non-melanoma skin cancer (basal cell carcinoma) has decreased. The high burden of skin and subcutaneous diseases demand that they be given due importance in the national programmes and health policy of India.

scholarly journals Dementias in Brazil: increasing burden in the 2000–2016 period. Estimates from the Global Burden of Disease Study 2016

2020 ◽  
Vol 78 (12) ◽  
pp. 762-771
Author(s):  
Simone Cecília de Melo ◽  
Ana Paula Silva Champs ◽  
Rúbia Ferreira Goulart ◽  
Deborah Carvalho Malta ◽  
Valéria Maria de Azeredo Passos
Keyword(s):  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Diagnostic Measures ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Growth And Aging ◽  
Disease Study ◽  
Years Lived With Disability

ABSTRACT Introduction: Dementia is a globally relevant health problem, which places a great burden on patients and their families. This study aimed to estimate the burden associated with Alzheimer's disease (AD) and other dementias in Brazil. Methods: In this descriptive study, we investigated the estimates obtained by the Global Burden of Disease study. We described the prevalence of AD and other dementias, years lived with disability (YLDs), age-standardized mortality, years of life lost (YLLs), and disability-adjusted life years (DALYs) among individuals aged 60 years or older between 2000 and 2016, with their respective 95% uncertainty intervals (95%UI). Results: During this period, the age-standardized prevalence of AD and other dementias per 100,000 people increased by 7.8%, from 961.7 (95%UI 828.3–1,117.5) to 1,036.9 (95%UI 882.0–1,219.5), with approximately 1.5 million people living with dementia in Brazil. The incidence increased by 4.5%. Similarly, all age-standardized rates had an upward trend (mortality: 3.1%; YLLs: 5.8%; YLDs: 7.9%; and DALYs: 6.3%). Mortality profiles increased with age in both years. Dementias were ranked fourth among the leading causes of death in people aged ≥70 years in 2000, rising to second place in 2016. In 2016, it also represented the second and third leading causes of disability among older women and men, respectively. Conclusion: Population growth and aging have resulted in an increased burden of AD and other dementias in Brazil. Preventive and early diagnostic measures are essential to mitigate the burden associated with these diseases.

scholarly journals Disability-Adjusted Life Years (DALY) for Cancers in Iran, 1990 to 2016: Review of Findings from the Global Burden of Disease Study

2021 ◽  
Author(s):  
Azin Nahvijou
Keyword(s):  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Cancer Burden ◽  
Screening Programs ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Icd 10 ◽  
Disease Study

Background: Cancer with 13% of all deaths is the third leading cause of mortality in Iran. We aimed to assess the burden of cancer in Iran by acquiring data from the Global Burden of Disease (GBD) study. Methods: This study was conducted on the DALY approach to examine the cancer burden in Iran from 1990 to 2016. A list of all cancers was extracted using the International Classification of Disease, tenth revision (ICD-10). Then, the cancer burden was assessed based on the type of cancer. The Percentage change (PC) by Daly’s number and age-standardized DALY rate (ASDR) was estimated. The cause of PC on the DALYs number from cancer was analyzed, and the share of every variable was determined. Results: In 2016, cancer caused 781.5 and 564 thousand DALYs for men and women, respectively. In all years, the DALYs number of cancer is higher in men than women. From 1990 to 2016, leukemia, stomach, tracheal, bronchus and lung (TBL) cancers were among the leading causes of cancer burden in Iran. The highest increase in PC of cancer DALYs from 1990 to 2016 happened by multiple myeloma with 302.4% and breast with 283.7%. The lowest increase occurred by Hodgkin lymphoma (-2.1%) and leukemia (18.2%). Conclusion: Cancers have grown more than doubled in terms of DALYs from 1990 to 2016. The majority of DALYs were due to Years of Life Lost, suggesting the need for prevention, early detection, and screening programs.

scholarly journals Aumento da carga de dengue no Brasil e unidades federadas, 2000 e 2015: análise do Global Burden of Disease Study 2015

2017 ◽  
Vol 20 (suppl 1) ◽  
pp. 205-216 ◽  
Author(s):  
Valdelaine Etelvina Miranda de Araújo ◽  
Juliana Maria Trindade Bezerra ◽  
Frederico Figueiredo Amâncio ◽  
Valéria Maria de Azeredo Passos ◽  
Mariângela Carneiro
Keyword(s):  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study ◽  
Years Lived With Disability

RESUMO: Objetivo: Descrever as principais métricas sobre dengue geradas pelo Global Burden of Disease (GBD) Study 2015, para o Brasil e suas 27 unidades federadas, nos anos de 2000 e 2015. Métodos: As métricas descritas foram: taxas de incidência e de mortalidade por dengue, padronizadas por idade, years of life lost (YLL), years lived with disability (YLD) e disability adjusted life years (DALY) (frequência absoluta e taxas padronizadas por idade). As métricas estimadas foram apresentadas com intervalos de incerteza (II 95%) para 2000 e 2015, acompanhadas da variação relativa percentual. Resultados: Verificou-se aumento de 232,7% no número de casos e de 639,0% no número de mortes entre os anos de 2000 e 2015 no país. A taxa de incidência variou 184,3% e a taxa de mortalidade mostrou-se baixa, mas com aumento de 500,0% no período avaliado. As taxas de YLL, YLD e DALY aumentaram 420,0, 187,2 e 266,1%, respectivamente. Em 2015, DALY foi semelhante entre mulheres e homens (21,9/100.000). O DALY aumentou mais que o dobro em todas as unidades da federação. Conclusão: O aumento acentuado de dengue ao longo dos anos associa-se à introdução e/ou circulação de um ou mais sorotipos do vírus e crescente proporção de pacientes acometidos pela forma grave da doença. Apesar da baixa taxa de mortalidade, a dengue contribui para considerável perda de anos saudáveis de vida no Brasil por acometer elevado número de pessoas, de todas as faixas etárias, ocasionando algum grau de incapacidade durante a infecção sintomática, e em razão dos óbitos, principalmente, em crianças.

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