Variation in Cause-Specific Mortality Rates in Italy during the First Wave of the COVID-19 Pandemic: A Study Based on Nationwide Data

Italy was a country severely hit by the first coronavirus disease 2019 (COVID-19) pandemic wave in early 2020. Mortality studies have focused on the overall excess mortality observed during the pandemic. This paper investigates the cause-specific mortality in Italy from March 2020 to April 2020 and the variation in mortality rates compared with those in 2015–2019 regarding sex, age, and epidemic area. Causes of death were derived from the national cause-of-death register. COVID-19 was the leading cause of death among males and the second leading cause among females. Chronic diseases, such as diabetes and hypertensive, ischemic heart, and cerebrovascular diseases, with decreasing or stable mortality rates in 2015–2019, showed a reversal in the mortality trend. Moreover, mortality due to pneumonia and influenza increased. No increase in neoplasm mortality was observed. Among external causes of death, mortality increased for accidental falls but reduced for transport accidents and suicide. Mortality from causes other than COVID-19 increased similarly in both genders and more at ages 65 years or above. Compared with other areas in Italy, the Lombardy region showed the largest excess in mortality for all leading causes. Underdiagnosis of COVID-19 at the beginning of the pandemic may, to some extent, explain the mortality increase for some causes of death, especially pneumonia and other respiratory diseases.

Ethnobotanical Documentation of Medicinal Plants Used by the Indigenous Panay Bukidnon in Lambunao, Iloilo, Philippines

The Panay Bukidnon is a group of indigenous peoples living in the interior highlands of Panay Island in Western Visayas, Philippines. Little is known about their ethnobotanical knowledge due to limited written records, and no recent research has been conducted on the medicinal plants they used in ethnomedicine. This study aims to document the medicinal plants used by the indigenous Panay Bukidnon in Lambunao, Iloilo, Panay Island. Semi-structured interviews were conducted with 75 key informants from June 2020 to September 2021 to determine the therapeutic use of medicinal plants in traditional medicine. A total of 131 medicinal plant species distributed in 121 genera and 57 families were used to address 91 diseases in 16 different uses or disease categories. The family Fabaceae was best represented with 13 species, followed by Lamiaceae with nine species and Poaceae with eight species. The leaf was the most frequently used plant part and decoction was the most preferred form of preparation. To evaluate the plant importance, use value (UV), relative frequency citation (RFC), relative important index (RI), informant consensus factor (ICF), and fidelity level (FL) were used. Curcuma longa L. had the highest UV (0.79), Artemisia vulgaris L. had the highest RFC value (0.57), and Annona muricata L. had the highest RI value (0.88). Diseases and symptoms or signs involving the respiratory system and injury, poisoning, and certain other consequences of external causes recorded the highest ICF value (0.80). Blumea balsamifera (L.) DC. and Chromolaena odorata (L.) R.M. King & H. Rob were the most relevant and agreed species for the former and latter disease categories, respectively. C. odorata had the highest FL value (100%) and was the most preferred medicinal plant used for cuts and wounds. The results of this study serve as a medium for preserving cultural heritage, ethnopharmacological bases for further drug research and discovery, and preserving biological diversity.

Deterioration Mechanisms and Advanced Inspection Technologies of Aluminum Windows

Aluminum windows are crucial components of building envelopes since they connect the indoor space to the external environment. Various external causes degrade or harm the functioning of aluminum windows. In this regard, inspecting the performance of aluminum windows is a necessary task to keep buildings healthy. This review illustrates the deterioration mechanisms of aluminum windows under various environmental conditions with an intention to provide comprehensive information for developing damage protection and inspection technologies. The illustrations reveal that moisture and chloride ions have the most detrimental effect on deteriorating aluminum windows in the long run, while mechanical loads can damage aluminum windows in a sudden manner. In addition, multiple advanced inspection techniques potential to benefit assessing aluminum window health state are discussed in order to help tackle the efficiency problem of traditional visual inspection. The comparison among those techniques demonstrates that infrared thermography can help acquire a preliminary defect profile of inspected windows, whereas ultrasonic phased arrays technology demonstrates a high level of competency in analyzing comprehensive defect information. This review also discusses the challenges in the scarcity of nanoscale corrosion information for insightful understandings of aluminum window corrosion and reliable window inspection tools for lifespan prediction. In this regard, molecular dynamics simulation and artificial intelligence technology are recommended as promising tools for better revealing the deterioration mechanisms and advancing inspection techniques, respectively, for future directions. It is envisioned that this paper will help upgrade the aluminum window inspection scheme and contribute to driving the construction of intelligent and safe cities.

Promising measures to reduce the mortality in Russia: an analytical review

The purpose of the study was to identify promising measures to reduce mortality in Russia. Methods used included analysis of systematic reviews from PubMed, Web of Science, Scopus, and Google Scholar. Results. Many reasonable measures for reducing mortality in Russia include promoting healthy behaviour (tobacco control, alcohol control, support for healthy diet, physical activity) and preventing death due to external causes. It is necessary to increase the effectiveness of disease management, including arterial hypertension, hypercholesterolemia, diabetes mellitus, cardiovascular accidents, hepatitis C, HIV. This could require intensifying digital transformation of health care, implementing modern teamwork approaches to the patient’s treatment and follow-up with greater involvement of nurses and other personnel. In terms of screening, it is essential to expand coverage and introduce modern, effective screening methods for colorectal cancer, cervical cancer, and neonatal screening. It is necessary to expand vaccination against Covid-19, vaccination of the elderly from Pneumococcus, and adolescents from HPV. Prevention of mortality from external causes should include sets of measures targeted at the prevention of suicides, traffic accidents, fires, drownings, etc., in addition to alcohol control measures. Finally, increasing health care financing, including medication provision, can bring additional years of life. Conclusions. Russia has significant potential to implement new measures to reduce the mortality rate.

Life expectancy of population of the northern regions in the Russian Federation: Tendencies and potential for growth

The article is devoted to the tendencies in life expectancy of population of the northern regions of Russia in the context of growth and regional convergence indicator in the early 2000s and possibilities for its further growth. The sources of information are the official Rosstat data. Life expectancy in the North has been found to be largely subordinate to the Russian-wide patterns of the regional convergence: the compaction of the northern constituent entities to the national average level occurred at both the top and bottom levels. Both the Khanty-Mansiysk and Yamal-Nenets Autonomous Districts experienced a significant decline, as did the gap in most regions with life expectancy below that of the Russian Federation. Only Kamchatka Krai and Magadan Oblast increased the lag, while maintaining group affiliation in the regional grouping in terms of life expectancy. The potential for the further growth in life expectancy in the North is being determined by the insufficient reduction in mortality caused by the circulatory system diseases and increase in the neoplasm mortality within the period of 2003–2019, and environmental and behavioral risk factors reflected in the differences in life expectancy in different settlements, its gender differentiation and the high level of mortality from external causes. The large difference in life expectancy between urban and rural areas makes the large potential in the northern regions except Murmansk Oblast and partly the Sakha Republic (Yakutia). Almost all northern constituent entities have a significant potential posed by the male under-representation indicator. Despite a significant rate of decline, external causes of death and their share in cause-related mortality are widespread in the North. With the exception of the Chukotka Autonomous District, within recent years, infant mortality rate in the North has been fairly good — it can no longer be considered as a potential for the life expectancy growth of population.

Pediatric Medication Noninitiation in Spain

OBJECTIVES To estimate medication noninitiation prevalence in the pediatric population and identify the explanatory factors underlying this behavior. METHODS Observational study of patients (<18 years old) receiving at least 1 new prescription (28 pharmaceutical subgroups; July 2017 to June 2018) in Catalonia, Spain. A prescription was considered new when there was no prescription for the same pharmaceutical subgroup in the previous 6 months. Noninitiation occurred when a prescription was not filled within 1 month or 6 months (sensitivity analysis). Prevalence was estimated as the proportion of total prescriptions not initiated. To identify explanatory factors, a multivariable multilevel logistic regression model was used, and adjusted odds ratios were reported. RESULTS Overall, 1 539 003 new prescriptions were issued to 715 895 children. The overall prevalence of 1-month noninitiation was 9.0% (ranging from 2.6% [oral antibiotics] to 21.5% [proton pump inhibitors]), and the prevalence of 6-month noninitiation was 8.5%. Noninitiation was higher in the youngest and oldest population groups, in children from families with a 0% copayment rate (vulnerable populations) and those with conditions from external causes. Out-of-pocket costs of drugs increased the odds of noninitiation. The odds of noninitiation were lower when the prescription was issued by a pediatrician (compared with a primary or secondary care clinician). CONCLUSIONS The prevalence of noninitiation of medical treatments in pediatrics is high and varies according to patients’ ages and medical groups. Results suggest that there are inequities in access to pharmacologic treatments in this population that must be taken into account by health care planners and providers.

An Approach to the Anthropological Theory of the Qur’an and Hadith and Their Roles in Reducing Environmental Degradation

Background: According to the Qur’an, man is the servant and the successor of Allah, the representative of prosperity on earth, and has the responsibility for the universe. This approach will create a constructive human interaction with the environment. Environmental degradation is against the will of Allah. It originates from ignorance, human selfishness, passions, and evil temptations, manifest in greed, arrogance, and extravagance. If humans control these abnormal factors and follow Qur’an teachings, they will enjoy a healthy environment that is a universal right. This paper seeks to study the anthropological theory of the Qur’an and its role in reducing environmental degradation. Methods: Based on the descriptive-analytical design, we explored 70 verses of the Holy Qur’an in which the words samā’, ‘ard, mas’ūl, khalīfah, shaytān, and those are cognate with the Arabic verbs sa-khkha-ra, ha-ra-sa, sa-ra-fa, ki-ba-ra, ha-wā, ‘a-ba-da, and ‘a-ma-ra, as well as the related articles, books, and philological and exegetical sources. We investigated the Qur’an to find the effect of awareness and more attention of human beings to the dimensions of man’s creation to reduce environmental degradation. These issues will be discussed in two parts: 1) the anthropology and the dimensions of human creation in the Qur’an, and 2) the causes of environmental degradation. Results: This study showed that the survival of life and human enjoyment of a healthy environment depends on enough knowledge of oneself, seeking help from Allah, and following the Qur’anic guidelines. These facts effectively control internal and external causes of environmental degradation, including ignorance, egoism, selfishness, and evil temptations. These actions destroy the roots of greed, arrogance, and extravagance in human beings. For this reason, Allah demands humans to develop earth, care for and rescue it from any destruction, avoid extravagance, and observe justice. Conclusion: Meditating in the Qur’an, the man knows his creative dimensions and environmental degradation factors that are incompatible with nature and are rooted in some of the inner and outer dimensions of human personality. Hence, he will consciously enjoy sustainable development and maintaining a healthy environment. This behavior will then reduce anomalies in the environment on his part.

Nutrition and Physical Activity-Induced Changes in Gut Microbiota: Possible Implications for Human Health and Athletic Performance

The gut microbiota is a complex heterogeneous microbial community modulated by endogenous and exogenous factors. Among the external causes, nutrition as well as physical activity appear to be potential drivers of microbial diversity, both at the taxonomic and functional level, likely also influencing endocrine system, and acting as endocrine organ itself. To date, clear-cut data regarding which microbial populations are modified, and by which mechanisms are lacking. Moreover, the relationship between the microbial shifts and the metabolic practical potential of the gut microbiota is still unclear. Further research by longitudinal and well-designed studies is needed to investigate whether microbiome manipulation may be an effective tool for improving human health and, also, performance in athletes, and whether these effects may be then extended to the overall health promotion of general populations. In this review, we evaluate and summarize the current knowledge regarding the interaction and cross-talks among hormonal modifications, physical performance, and microbiota content and function.