Cardiopulmonary fitness is related to disease severity in multiple sclerosis

2015 ◽  
Vol 22 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Martin Heine ◽  
Inez Wens ◽  
Martin Langeskov-Christensen ◽  
Olaf Verschuren ◽  
Bert O Eijnde ◽  
...  
Keyword(s):  
Disease Severity ◽  
Close Relation ◽  
Progressive Increase ◽  
Peak Oxygen Uptake ◽  
Multiple Regression Model ◽  
Exercise Tests ◽  
Cardiopulmonary Fitness ◽  
Disability Status ◽  
Related Quality ◽  
Health Related

Background: In persons with MS (pwMS), a lower cardiopulmonary fitness has been associated with a higher risk for secondary disorders, decreased functional capacity, symptom worsening and reduced health-related quality of life. Objective: To investigate the association between disease severity and cardiopulmonary fitness. Methods: Data from cardiopulmonary exercise tests, previously conducted in three different countries, were pooled. The association between disease severity (Expanded Disability Status Scale (EDSS)) and cardiopulmonary fitness (peak oxygen uptake (VO2peak)) was adjusted for age, sex and the country of origin. Results: The combined sample comprised 116 ambulant pwMS having a mean (± SD) EDSS score of 2.7 ± 1.3. There was a significant correlation ( r = -0.418, p < .01) between VO2peak and EDSS. A multiple regression model (R2 = 0.520, p < .01) was constructed to describe VO2peak (mL∙kg−1∙min−1); VO2peak = 36.622 − 5.433 (Sex (1=men)) – 0.124 (Age) − 2.082 (EDSS) + 2.737 (Belgium) + 8.674 (Denmark). Conclusion: There was a significant association between disease severity and cardiopulmonary fitness. The close relation between cardiopulmonary fitness and chronic conditions associated with physical inactivity, suggest a progressive increase in risk of secondary health conditions in pwMS

510 A Profile of Physical Performance Variables in an Out-Patient Adult Population with Narcolepsy

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A201-A201
Author(s):  
Ragy Tadrous ◽  
Julie Broderick ◽  
Niamh Murphy ◽  
Lisa Slattery ◽  
Gillian Quinn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Physical Performance ◽  
Symptom Severity ◽  
Health Related Quality ◽  
Cardiopulmonary Fitness ◽  
Performance Variables ◽  
Related Quality ◽  
Health Related

Abstract Introduction Narcolepsy can significantly impact the physical and mental wellbeing of people with narcolepsy, and has been associated with significant reductions in quality of life and physical performance. People with narcolepsy demonstrate many barriers to being physically fit and active, such as sleepiness and social isolation. Despite physical functioning and vitality being the most affected domains of health-related quality of life in this cohort, little is known about how physical performance variables are affected in people with narcolepsy. Methods This cross-sectional study profiled the physical performance of adults with narcolepsy attending the Narcolepsy Centre located in St. James’s Hospital. Participants underwent a physical performance test battery that investigated cardiopulmonary fitness, physical activity, muscle strength and endurance. Furthermore, health-related quality of life (HRQoL), symptom severity and sedentary behaviour was ascertained through self-report questionnaires. Results A total of 23 participants were recruited in this study. The majority of participants were female (n=13, 56.52%) and the mean age was 31.53 (± 13.17) years. Physical performance was generally found to be lower than age-and-gender matched normative values for cardiopulmonary fitness, physical activity and muscle strength and endurance. Participants’ completed 42.20 ± 21.41 minutes of moderate-vigorous physical activity daily as measured by actigraphy. Considerable sedentary behaviour was objectively measured in this sample (10.21 hours). Symptom severity was high as measured by the Epworth Sleepiness Scale and the Narcolepsy Severity Scale, and participants reported reduced quality of life when compared to general population norms (US, UK, France and Norway). Conclusion Markedly reduced physical performance was identified in this sample of people with narcolepsy, irrespective of participant age, gender and BMI. Future research should explore the role of exercise in improving the physical fitness in people with narcolepsy, and the influence of exercise on HRQoL and symptom severity in this cohort. Support (if any) This study was completed as part of Mr Ragy Tadrous’ Master of Science (MSc) degree in Trinity College Dublin. This degree was co-sponsored by the Physiotherapy Department in St. James’s Hospital, Dublin.

A Comparison of the Level of Dyspnea vs Disease Severity in Indicating the Health-Related Quality of Life of Patients With COPD

CHEST Journal ◽  
1999 ◽  
Vol 116 (6) ◽  
pp. 1632-1637 ◽  
Author(s):  
Takashi Hajiro ◽  
Koichi Nishimura ◽  
Mitsuhiro Tsukino ◽  
Akihiko Ikeda ◽  
Toru Oga ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals New insights into the burden and costs of multiple sclerosis in Europe: Results for France

2017 ◽  
Vol 23 (2_suppl) ◽  
pp. 65-77 ◽  
Author(s):  
Christine Lebrun-Frenay ◽  
Gisela Kobelt ◽  
Jenny Berg ◽  
Daniela Capsa ◽  
Mia Gannedahl ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Work Capacity ◽  
Outcome Data ◽  
Current Data ◽  
Cross Sectional ◽  
Disability Status ◽  
Related Quality ◽  
Experienced Fatigue ◽  
Health Related

Introduction: To estimate the value of interventions in multiple sclerosis (MS) – where lifetime costs and outcomes cannot be observed – outcome data have to be combined with costs. This requires that cost data be regularly updated. Objectives and methods: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, in the societal perspective, in EUR 2015. Results: A total of 491 patients (mean age 47 years) participated; 82% were below retirement age, and of these 56% were employed. Employment was related to disease severity, and MS affected productivity at work for 90% of patients. Overall, 95% and 67% of patients experienced fatigue and cognition as a problem, respectively. The mean utility and annual costs were 0.735 and €22,600 at Expanded Disability Status Scale (EDSS) 0–3, 0.500 and €38,100 at EDSS 4–6.5, and 0.337 and €48,100 at EDSS 7–9, respectively. The average cost of a relapse was estimated at €2300. Conclusion: This study provides current data on MS in France that are important for developments of health policies and to estimate the value of current and future treatments.

scholarly journals New insights into the burden and costs of multiple sclerosis in Europe: Results for Austria

2017 ◽  
Vol 23 (2_suppl) ◽  
pp. 17-28 ◽  
Author(s):  
Thomas Berger ◽  
Gisela Kobelt ◽  
Jenny Berg ◽  
Daniela Capsa ◽  
Mia Gannedahl ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Work Capacity ◽  
Outcome Data ◽  
Current Data ◽  
Cross Sectional ◽  
Disability Status ◽  
Related Quality ◽  
Experienced Fatigue ◽  
Health Related ◽  
Mean Cost

Introduction: In order to estimate the value of interventions in multiple sclerosis (MS) – where lifetime costs and outcomes cannot be observed – outcome data have to be combined with costs. This requires that cost data be regularly updated. Objectives and Methods: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, from the societal perspective, in EUR 2015. Results: A total of 516 patients (mean age, 53 years) participated in Austria; 72% were below retirement age, and of these, 46% were employed. Employment was related to disability, and MS affected productivity at work for 77% of those working. Overall, 94% and 67% of patients experienced fatigue and cognition as a problem. Mean utility and total annual costs were 0.778 and 25,100€ at Expanded Disability Status Scale (EDSS) 0–3, 0.579 and 44,100€ at EDSS 4–6.5, and 0.244 and 73,800€ at EDSS 7–9. The mean cost of a relapse was estimated at 2563€. Conclusion: This study illustrates the burden of MS on Austrian patients and provides current data on MS that are important for development of health policies.

Health-Related Quality of Life, Disease Severity, and Anticipated Trajectory of Diabetes

2012 ◽  
Vol 39 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Melissa Scollan-Koliopoulos ◽  
David Bleich ◽  
Kenneth J. Rapp ◽  
Patrick Wong ◽  
Cynthia J. Hofmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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