scholarly journals Corrigendum

2018 ◽  
Vol 24 (6) ◽  
pp. NP1-NP1
Keyword(s):  
Multiple Sclerosis ◽  
Three Dimensional ◽  
Japanese Patients ◽  
Inversion Recovery ◽  
Double Inversion Recovery

Shinoda K, Matsushita T, Nakamura Y, et al. HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis. Mult Scler. Epub ahead of print 5 May 2017. DOI: 10.1177/1352458517707067

HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis

2017 ◽  
Vol 24 (6) ◽  
pp. 710-720 ◽  
Author(s):  
Koji Shinoda ◽  
Takuya Matsushita ◽  
Yuri Nakamura ◽  
Katsuhisa Masaki ◽  
Ryo Yamasaki ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Three Dimensional ◽  
Multivariate Logistic Regression Analysis ◽  
Clinical Information ◽  
Japanese Patients ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Inversion Recovery Imaging ◽  
Disability Status ◽  
Caucasian Patients

Background: Cortical lesions (CLs) frequently observed in Caucasian patients with multiple sclerosis (MS) contribute to disability. However, it remains unclear whether CLs are associated with clinical features and genetic risk factors, such as HLA-DRB1*15:01 and -DRB1*04:05 in Asian MS patients. Objective: To elucidate the frequency of CLs and their association with HLA-DRB1 and DPB1 alleles in Japanese MS patients. Methods: Three-dimensional double inversion recovery imaging and clinical information were retrospectively obtained from 92 Japanese MS patients. Results: CLs of any type, intracortical lesions (ICLs), and leukocortical lesions (LCLs) were detected in 39.1%, 26.1%, and 28.3% of patients, respectively. MS patients with ICLs had a significantly higher frequency of secondary progression and greater Expanded Disability Status Scale (EDSS) scores than those without ICLs. Similar trends were observed with CLs and LCLs. The number of all three lesion types positively correlated with EDSS scores. The frequency and number of ICLs were significantly higher in HLA-DRB1*15:01 carriers than in HLA-DRB1*15:01 non-carriers, but significantly lower in HLA-DRB1*04:05 carriers than in HLA-DRB1*04:05 non-carriers. Multivariate logistic regression analysis revealed a negative association of HLA-DRB1*04:05 with ICLs. Conclusion: ICLs are associated with greater disease severity in Japanese MS patients and are partly suppressed by the HLA-DRB1*04:05 allele.

scholarly journals A case of epilepsy in multiple sclerosis: Three-dimensional double inversion recovery sequences revealed cortical dysplasia

2017 ◽  
Vol 30 (4) ◽  
pp. 352-355 ◽  
Author(s):  
Domenico S Zimatore ◽  
Mirko Trentadue ◽  
Marco Castellaro ◽  
Monica Ferlisi ◽  
Enrico Piovan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Focal Cortical Dysplasia ◽  
Three Dimensional ◽  
Brain Magnetic Resonance Imaging ◽  
Cortical Dysplasia ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Mri Findings ◽  
Magnetic Resonance Imaging Mri ◽  
Fdg Pet Ct

In epileptic patients with multiple sclerosis (MS), cortical lesions have been suggested to cause seizures. In brain magnetic resonance imaging (MRI), double inversion recovery (DIR) sequences are generally used to evaluate MS cortical disease burden. We present the case of a woman, diagnosed with MS, suffering from drug-resistant partial seizures initially attributed to MS. The patient underwent many MRI exams, but only by means of high-resolution three-dimensional DIR sequences was a focal cortical dysplasia discovered. The MRI findings and FDG-PET/CT supported the diagnosis. This case recommends the use of DIR sequences both in patients with suspect epileptogenic lesions not detected with routine MRI protocols and in epileptic patient with MS, before ascribing seizures to MS.

Acute severe memory impairment as a presenting symptom of multiple sclerosis: a clinical case study with 3D double inversion recovery MR imaging

2010 ◽  
Vol 16 (12) ◽  
pp. 1521-1524 ◽  
Author(s):  
JAF Coebergh ◽  
SD Roosendaal ◽  
CH Polman ◽  
JJ Geurts ◽  
TCAM van Woerkom
Keyword(s):  
Multiple Sclerosis ◽  
Memory Impairment ◽  
Clinical Symptoms ◽  
Neuropsychological Testing ◽  
Three Dimensional ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Cortical Lesions ◽  
Mri Imaging ◽  
Clinical Case Study

We present the case of a 21-year-old woman with acute memory impairment. It was initially not recognized as organic in nature. Repeated neuropsychological testing confirmed severely disturbed encoding and recall. Three-dimensional double inversion recovery (3D-DIR) MRI confirmed hippocampal and cortical lesions. Further clinical symptoms, visual evoked potential and MRI suggested a diagnosis of multiple sclerosis (MS). The amnestic syndrome has remained for 5 years. This case illustrates that MS can present with acute cortical symptoms which can be difficult to recognize. The hippocampus can be acutely affected and DIR MRI imaging can help to demonstrate cortical lesions that explain the clinical picture.

scholarly journals Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla

2010 ◽  
Vol 20 (7) ◽  
pp. 1675-1683 ◽  
Author(s):  
Birgit Simon ◽  
Stephan Schmidt ◽  
Carsten Lukas ◽  
Jürgen Gieseke ◽  
Frank Träber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mr Imaging ◽  
Inversion Recovery ◽  
3 Tesla ◽  
Double Inversion Recovery ◽  
Cortical Lesions ◽  
In Vivo Detection

scholarly journals 3D MPRAGE improves classification of cortical lesions in multiple sclerosis

2008 ◽  
Vol 14 (9) ◽  
pp. 1214-1219 ◽  
Author(s):  
F Nelson ◽  
A Poonawalla ◽  
P Hou ◽  
JS Wolinsky ◽  
PA Narayana
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Inversion Recovery ◽  
High Signal ◽  
Cortical Lesions ◽  
Rapid Acquisition ◽  
Lesion Morphology

Background Gray matter lesions are known to be common in multiple sclerosis (MS) and are suspected to play an important role in disease progression and clinical disability. A combination of magnetic resonance imaging (MRI) techniques, double-inversion recovery (DIR), and phase-sensitive inversion recovery (PSIR), has been used for detection and classification of cortical lesions. This study shows that high-resolution three-dimensional (3D) magnetization-prepared rapid acquisition with gradient echo (MPRAGE) improves the classification of cortical lesions by allowing more accurate anatomic localization of lesion morphology. Methods 11 patients with MS with previously identified cortical lesions were scanned using DIR, PSIR, and 3D MPRAGE. Lesions were identified on DIR and PSIR and classified as purely intracortical or mixed. MPRAGE images were then examined, and lesions were re-classified based on the new information. Results The high signal-to-noise ratio, fine anatomic detail, and clear gray-white matter tissue contrast seen in the MPRAGE images provided superior delineation of lesion borders and surrounding gray-white matter junction, improving classification accuracy. 119 lesions were identified as either intracortical or mixed on DIR/PSIR. In 89 cases, MPRAGE confirmed the classification by DIR/PSIR. In 30 cases, MPRAGE overturned the original classification. Conclusion Improved classification of cortical lesions was realized by inclusion of high-spatial resolution 3D MPRAGE. This sequence provides unique detail on lesion morphology that is necessary for accurate classification.

scholarly journals Pre- and post-contrast three-dimensional double inversion-recovery MRI in human glioblastoma

2013 ◽  
Vol 112 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Robert J. Harris ◽  
Timothy F. Cloughesy ◽  
Whitney B. Pope ◽  
Sergio Godinez ◽  
Yutaka Natsuaki ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Post Contrast ◽  
Human Glioblastoma
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