HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis

2017 ◽  
Vol 24 (6) ◽  
pp. 710-720 ◽  
Author(s):  
Koji Shinoda ◽  
Takuya Matsushita ◽  
Yuri Nakamura ◽  
Katsuhisa Masaki ◽  
Ryo Yamasaki ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Three Dimensional ◽  
Multivariate Logistic Regression Analysis ◽  
Clinical Information ◽  
Japanese Patients ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Inversion Recovery Imaging ◽  
Disability Status ◽  
Caucasian Patients

Background: Cortical lesions (CLs) frequently observed in Caucasian patients with multiple sclerosis (MS) contribute to disability. However, it remains unclear whether CLs are associated with clinical features and genetic risk factors, such as HLA-DRB1*15:01 and -DRB1*04:05 in Asian MS patients. Objective: To elucidate the frequency of CLs and their association with HLA-DRB1 and DPB1 alleles in Japanese MS patients. Methods: Three-dimensional double inversion recovery imaging and clinical information were retrospectively obtained from 92 Japanese MS patients. Results: CLs of any type, intracortical lesions (ICLs), and leukocortical lesions (LCLs) were detected in 39.1%, 26.1%, and 28.3% of patients, respectively. MS patients with ICLs had a significantly higher frequency of secondary progression and greater Expanded Disability Status Scale (EDSS) scores than those without ICLs. Similar trends were observed with CLs and LCLs. The number of all three lesion types positively correlated with EDSS scores. The frequency and number of ICLs were significantly higher in HLA-DRB1*15:01 carriers than in HLA-DRB1*15:01 non-carriers, but significantly lower in HLA-DRB1*04:05 carriers than in HLA-DRB1*04:05 non-carriers. Multivariate logistic regression analysis revealed a negative association of HLA-DRB1*04:05 with ICLs. Conclusion: ICLs are associated with greater disease severity in Japanese MS patients and are partly suppressed by the HLA-DRB1*04:05 allele.

scholarly journals Corrigendum

2018 ◽  
Vol 24 (6) ◽  
pp. NP1-NP1
Keyword(s):  
Multiple Sclerosis ◽  
Three Dimensional ◽  
Japanese Patients ◽  
Inversion Recovery ◽  
Double Inversion Recovery

Shinoda K, Matsushita T, Nakamura Y, et al. HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis. Mult Scler. Epub ahead of print 5 May 2017. DOI: 10.1177/1352458517707067

scholarly journals A case of epilepsy in multiple sclerosis: Three-dimensional double inversion recovery sequences revealed cortical dysplasia

2017 ◽  
Vol 30 (4) ◽  
pp. 352-355 ◽  
Author(s):  
Domenico S Zimatore ◽  
Mirko Trentadue ◽  
Marco Castellaro ◽  
Monica Ferlisi ◽  
Enrico Piovan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Focal Cortical Dysplasia ◽  
Three Dimensional ◽  
Brain Magnetic Resonance Imaging ◽  
Cortical Dysplasia ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Mri Findings ◽  
Magnetic Resonance Imaging Mri ◽  
Fdg Pet Ct

In epileptic patients with multiple sclerosis (MS), cortical lesions have been suggested to cause seizures. In brain magnetic resonance imaging (MRI), double inversion recovery (DIR) sequences are generally used to evaluate MS cortical disease burden. We present the case of a woman, diagnosed with MS, suffering from drug-resistant partial seizures initially attributed to MS. The patient underwent many MRI exams, but only by means of high-resolution three-dimensional DIR sequences was a focal cortical dysplasia discovered. The MRI findings and FDG-PET/CT supported the diagnosis. This case recommends the use of DIR sequences both in patients with suspect epileptogenic lesions not detected with routine MRI protocols and in epileptic patient with MS, before ascribing seizures to MS.

Acute severe memory impairment as a presenting symptom of multiple sclerosis: a clinical case study with 3D double inversion recovery MR imaging

2010 ◽  
Vol 16 (12) ◽  
pp. 1521-1524 ◽  
Author(s):  
JAF Coebergh ◽  
SD Roosendaal ◽  
CH Polman ◽  
JJ Geurts ◽  
TCAM van Woerkom
Keyword(s):  
Multiple Sclerosis ◽  
Memory Impairment ◽  
Clinical Symptoms ◽  
Neuropsychological Testing ◽  
Three Dimensional ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Cortical Lesions ◽  
Mri Imaging ◽  
Clinical Case Study

We present the case of a 21-year-old woman with acute memory impairment. It was initially not recognized as organic in nature. Repeated neuropsychological testing confirmed severely disturbed encoding and recall. Three-dimensional double inversion recovery (3D-DIR) MRI confirmed hippocampal and cortical lesions. Further clinical symptoms, visual evoked potential and MRI suggested a diagnosis of multiple sclerosis (MS). The amnestic syndrome has remained for 5 years. This case illustrates that MS can present with acute cortical symptoms which can be difficult to recognize. The hippocampus can be acutely affected and DIR MRI imaging can help to demonstrate cortical lesions that explain the clinical picture.

Double Inversion Recovery Imaging of the Brain: Initial Experience and Comparison with Fluid Attenuated Inversion Recovery Imaging

1998 ◽  
Vol 16 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Karl Turetschek ◽  
Patrick Wunderbaldinger ◽  
Alexander A. Bankier ◽  
Thomas Zontsich ◽  
Oswald Graf ◽  
...  
Keyword(s):  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Initial Experience ◽  
Inversion Recovery Imaging ◽  
Fluid Attenuated Inversion Recovery ◽  
The Brain

A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis

2012 ◽  
Vol 18 (9) ◽  
pp. 1269-1277 ◽  
Author(s):  
T Saida ◽  
S Kikuchi ◽  
Y Itoyama ◽  
Q Hao ◽  
T Kurosawa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Phase Ii ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Japanese Patients ◽  
Double Blind ◽  
Parallel Group ◽  
Safety Outcomes ◽  
Secondary Endpoints ◽  
Caucasian Patients

Background: Fingolimod (FTY720) has previously shown clinical efficacy in phase II/III studies of predominantly Caucasian populations with multiple sclerosis (MS). Objectives: To report six-month efficacy and safety outcomes in Japanese patients with relapsing MS treated with fingolimod. Methods: In this double-blind, parallel-group, phase II study, 171 Japanese patients with relapsing MS were randomized to receive once-daily fingolimod 0.5 mg or 1.25 mg, or matching placebo for six months. The primary and secondary endpoints were the percentages of patients free from gadolinium (Gd)-enhanced lesions at months 3 and 6, and relapses over six months, respectively; safety outcomes were also assessed. Results: 147 patients completed the study. Higher proportions of patients were free from Gd-enhanced lesions at months 3 and 6 with fingolimod (0.5 mg: 70%, p = 0.004; 1.25 mg: 86%, p < 0.001) than with placebo (40%). Odds ratios for the proportions of relapse-free patients over six months favoured fingolimod versus placebo but were not significant. Adverse events related to fingolimod included transient bradycardia and atrioventricular block at treatment initiation, and elevated liver enzyme levels. Conclusions: This study demonstrated the clinical efficacy of fingolimod for the first time in Japanese patients with MS, consistent with the established effects of fingolimod in Caucasian patients.

scholarly journals Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla

2010 ◽  
Vol 20 (7) ◽  
pp. 1675-1683 ◽  
Author(s):  
Birgit Simon ◽  
Stephan Schmidt ◽  
Carsten Lukas ◽  
Jürgen Gieseke ◽  
Frank Träber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mr Imaging ◽  
Inversion Recovery ◽  
3 Tesla ◽  
Double Inversion Recovery ◽  
Cortical Lesions ◽  
In Vivo Detection
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