Optical coherence tomography and multiple sclerosis: Update on clinical application and role in clinical trials

2019 ◽  
Vol 26 (6) ◽  
pp. 624-639 ◽  
Author(s):  
Jeffrey Lambe ◽  
Shiv Saidha ◽  
Robert A Bermel
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trials ◽  
Optical Coherence Tomography ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Neuroprotective Effects ◽  
Non Invasive ◽  
Retinal Pathology ◽  
Resolution Imaging

Optical coherence tomography (OCT) has emerged as a fast, non-invasive, inexpensive, high-resolution imaging technique in multiple sclerosis (MS). Retinal layer quantification by OCT facilitates a ‘window’ into not only local retinal pathology but also global neurodegenerative processes, recognised to be the principal substrates of disability accumulation in MS. While OCT measures in MS have been demonstrated to reflect visual function, inflammatory activity outside of the visual pathways, disability measures including the prediction of disability progression, whole brain atrophy, and the differential neuroprotective effects of disease-modifying therapies, debate continues regarding the clinical utility of OCT in everyday practice. This review presents an overview of the evidence supporting OCT, with particular focus on its application in the MS clinic. We will also discuss the role of OCT in MS clinical trials to develop novel neuroprotective and potential remyelinating therapies.

scholarly journals Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography

Brain ◽  
2011 ◽  
Vol 134 (11) ◽  
pp. e193-e193 ◽  
Author(s):  
A. U. Brandt ◽  
T. Oberwahrenbrock ◽  
M. Ringelstein ◽  
K. L. Young ◽  
M. Tiede ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Retinal Pathology

scholarly journals The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis

2018 ◽  
Vol 8 (5) ◽  
pp. 323-335 ◽  
Author(s):  
Danko Coric ◽  
Jenny A Nij Bijvank ◽  
Laurentius J van Rijn ◽  
Axel Petzold ◽  
Lisanne J Balk
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Visual Pathway ◽  
Optical Coherence

scholarly journals Optical Coherence Tomography Angiography in Neurodegenerative Disorders

2020 ◽  
Vol 9 (6) ◽  
pp. 1706 ◽  
Author(s):  
Marco Pellegrini ◽  
Aldo Vagge ◽  
Lorenzo Ferro Desideri ◽  
Federico Bernabei ◽  
Giacinto Triolo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Neurodegenerative Disorders ◽  
Optical Coherence Tomography Angiography ◽  
Imaging Modality ◽  
Optical Coherence ◽  
Microvascular Damage ◽  
Future Directions ◽  
Non Invasive ◽  
Retinal Microcirculation

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible ‘window’ to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.

scholarly journals Dynamics of central remyelination and treatment evolution in a model of Multiple Sclerosis with Optic Coherence Tomography

2020 ◽  
Author(s):  
Rocío Benítez-Fernández ◽  
Carolina Melero-Jerez ◽  
Carmen Gil ◽  
Enrique de la Rosa ◽  
Ana Martínez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Clinical Trials ◽  
Optical Coherence Tomography ◽  
Invasive Technique ◽  
Optic Coherence Tomography ◽  
Non Invasive ◽  
Disease Modifying ◽  
Ms Therapy

AbstractThe need for remyelinating drugs is essential for healing important diseases such as multiple sclerosis (MS). One of the reasons for the lack of this class of therapies is the impossibility to follow remyelination in vivo, which is of utmost importance to perform good clinical trials. Here, we show how the optical coherence tomography (OCT), a cheap and non-invasive technique commonly used in ophthalmology, may be used to follow remyelination in vivo in MS patients. Our pioneer study validates the study of myelin/remyelination in the optic nerve using OCT and reflects what is occurring in non accessible CNS structures, like the spinal cord. For this study we used the oral bioavailable small molecule VP3.15, confirming its therapeutical potential as neuroprotective, antinflammatory and remyelinating drug for MS. Altogether, our present results confirm the usefulness of OCT to monitor the effectivity of remyelinating therapies in vivo and underscore the relevance of VP3.15 as potential disease modifying drug for MS therapy.

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