Is moderate alcohol intake in pregnancy associated with the craniofacial features related to the fetal alcohol syndrome?

1995 ◽  
Vol 23 (3) ◽  
pp. 156-161 ◽  
Author(s):  
Jørn Olsen ◽  
Pitchaya Tuntiseranee
1998 ◽  
Vol 17 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Ernest L. Abel

Deborah Mathieu's proposal for state intervention in the lives of pregnant substance abusers in order to prevent serious harm to their future children sparked a lively debate in this journal. The present discussion characterizes the three main arguments offered against her proposal as (a) the “uncertainty principle''—the inability to predict which fetuses will be affected, (b) the “father factor”—gender bias with respect to prenatal damage, and (c) “critical periods”—the vulnerability of the embryo/fetus at different times of pregnancy. Each of these arguments is examined in the specific context of fetal alcohol syndrome (FAS). Since the birth of a child with FAS is a virtual certainty if a woman has previously given birth to a child with FAS, since no father has ever sired a child with FAS unless his spouse is an alcoholic, and since the most damaging effects are those associated with exposure throughout and especially late in pregnancy, none of the arguments offered against Mathieu's proposal are relevant in this particularly narrow set of circumstances. While Mathieu's proposal seems pertinent in this situation, her proposal would be even more effective if modified as suggested here.


PEDIATRICS ◽  
1994 ◽  
Vol 93 (2) ◽  
pp. 211-215
Author(s):  
Margaret A. Pearson ◽  
Mary E. Rimsza ◽  
H. Eugene Hoyme ◽  
Laurie H. Seaver

Objective. To determine if maternal toluene abuse produces any structural or developmental disabilities in the developing fetus, a cohort of toluene-exposed infants was ascertained and examined. Methodology. Eighteen infants with a history of in utero toluene exposure were examined at birth. Nine of these infants were reexamined 3 to 36 months after their initial evaluations. The clinical findings in these patients were compared with those of similarly exposed children from the literature and with patients who had the fetal alcohol syndrome. Results. Thirty-nine percent of all toluene-exposed infants described in this and other studies were born prematurely, and 9% died during the perinatal period. Fifty-four percent were small for gestational age, and 52% exhibited continued postnatal growth deficiency. A 33% incidence of prenatal microcephaly, a 67% incidence of postnatal microcephaly, and an 80% incidence of developmental delay were observed. Eighty-three percent of the patients had craniofacial features similar to the fetal alcohol syndrome, and 89% of these children had other minor anomalies. Conclusions. Data from the patients herein described and the available scientific literature suggest that the mechanism of alcohol craniofacial teratogenesis may be nonspecific, with a variety of teratogens, including toluene, giving rise to phenotypic facial abnormalities similar to those of the fetal alcohol syndrome. We propose a common mechanism of craniofacial teratogenesis for toluene and alcohol, namely a deficiency of craniofacial neuroepithelium and mesodermal components due to increased embryonic cell death.


PEDIATRICS ◽  
1974 ◽  
Vol 53 (4) ◽  
pp. 490-494
Author(s):  
R. Heather Palmer ◽  
Eileen M. Ouellette ◽  
Lyle Warner ◽  
Sandra R. Leichtman

Three cases in one family—a girl and monozygotic girl twins, the offspring of a chronic alcoholic mother —are presented. They show a pattern of prenatal onset of growth deficiency and developmental delay, with microcephaly, small palpebral fissures, and multiple minor anomalies, recently described in a series of 11 unrelated cases by Jones et al. and named by them the "fetal alcohol syndrome." After considering alternative theories, we conclude, with them, that the cases demonstrate an association between the maternal alcohol intake and the abnormalities found in the offspring. We report these three cases in confirmation of their findings.


PEDIATRICS ◽  
1981 ◽  
Vol 67 (1) ◽  
pp. 100-100
Author(s):  
T. E. C.

John Eberle (1788-1838) in his Treatise on the Diseases and Physical Education of Children, published in 1833, included a chapter on the conduct of mothers during pregnancy. Long before the current concern about the fetal alcohol syndrome, Eberle, almost a century and a half ago, was warning prospective mothers about the "ruinous effects" of alcohol on the fetus, as is evident in the following quotation.1 The majority of children born of decidedly intemperate mothers, are weak and sickly, and but few of them arrive at the age of adolescence. Many females appear to think, that although these and other melancholy consequences follow in the train of habitual intemperance, it is extremely improbable that any injury can result to themselves or the foetus, from the occasional use of small portions of spirituous liquors. Were it indeed absolutely certain, that the use of such potations, would always be restricted to occasional small portions, the indulgence would perhaps, rarely occasion any serious consequences. But as no prudence and resolution can be safely regarded as an entire protection against the gradual formation of the habit of intemperance, where such drinks are occasionally taken during gestation, even though it be at very considerable intervals and in very moderate quantities at first, it is far the safest plan, to abstain wholly from every kind of spirituous liquors.


Sign in / Sign up

Export Citation Format

Share Document