scholarly journals Value of Abdominal Susceptibility-Weighted Magnetic Resonance Imaging for Quantitative Assessment of Hepatic Iron Deposition in Patients with Chronic Hepatitis B: Comparison with Serum Iron Markers

2012 ◽  
Vol 40 (3) ◽  
pp. 1005-1015 ◽  
Author(s):  
W Lv ◽  
F Yan ◽  
M Zeng ◽  
J Zhang ◽  
Y Yuan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chronic Hepatitis ◽  
Magnetic Resonance ◽  
Serum Iron ◽  
Hbv Infection ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Healthy Controls ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging

OBJECTIVE: To assess hepatic iron deposition quantitatively in patients with chronic hepatitis B (HBV) infection, using abdominal susceptibility-weighted magnetic resonance imaging (SWI). METHODS: Patients with HBV infection and healthy controls underwent abdominal SWI and were assessed for serum iron markers. Phase values were measured and five grades of hepatic iron deposition were described by SWI. RESULTS: Patients with HBV infection ( n = 327) and healthy controls ( n = 50) were prospectively enrolled. In total, 77 (25.4%) patients with HBV infection had hepatic iron deposition as determined by SWI. Phase values were significantly different between patients with hepatic iron deposition compared with patients without hepatic iron deposition or controls, and were significantly different across different grades of hepatic iron deposition. Serum iron, ferritin, transferrin and transferrin saturation were significantly higher in patients with, versus those without, hepatic iron deposition. Only serum ferritin was significantly different across different grades of hepatic iron deposition, and there was a low inverse correlation between serum ferritin and phase values. CONCLUSIONS: Compared with serum iron markers, abdominal SWI may represent a powerful tool to assess hepatic iron deposition quantitatively in patients with chronic HBV infection.

Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C

Hepatology ◽  
2007 ◽  
Vol 46 (3) ◽  
pp. 658-665 ◽  
Author(s):  
Maïté Lewin ◽  
Armelle Poujol-Robert ◽  
Pierre-Yves Boëlle ◽  
Dominique Wendum ◽  
Elisabeth Lasnier ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Magnetic Resonance ◽  
Chronic Hepatitis C ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging

scholarly journals The impact of magnetic resonance imaging in the assessment of iron overload in heart and liver in transfusion-dependent thalassemic children: Minia experience

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Ashraf M. El Sherif ◽  
Ahmed S. Ibrahim ◽  
Mohamed A. Elsayed ◽  
Ahmed S. Abdelhakim ◽  
Ahlam M. Ismail
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Resonance Imaging ◽  
Liver Iron ◽  
Cardiac Iron ◽  
Cardiac Iron Overload

Abstract Background Thalassemia is the most prevalent single-gene disorder. Myocardial and hepatic iron depositions lead to complications and eventually death. We aimed to assess the diagnostic efficacy of magnetic resonance imaging T2* (MRI T2*) in quantifying iron overload in liver and heart in transfusion-dependent B-thalassemia major (TDT) children. Methods Prospective clinical study was carried on sixty children diagnosed with TDT. All of them underwent laboratory investigations, including CBC, serum iron, and ferritin levels. MRI T2* of the heart and liver was carried out to measure the iron overload and estimate the left ventricular ejection fraction (LVEF). Results Thirty-eight males and 22 females with TDT with a mean age of 13.23 years were included. Twenty cases (33.3%) had severe liver iron overload, while 36 (60%) had normal cardiac iron. There was a moderate significant negative association between hepatic and cardiac iron deposition (P = 0.03). All cases with severe cardiac iron overload had impaired LVEF below 56%. A non-significant positive association was noticed between cardiac iron deposition and LVEF in T2* (P = 0.08). A moderate negative significant association was detected between hepatic iron deposition and serum ferritin, while a fair negative significant association was found between serum ferritin and cardiac iron deposition with P values of 0.04 and 0.02, respectively. Conclusion MRI T2* is the gold standard for monitoring and follow-up of iron overload in the heart and liver. It should be routinely performed in all TDT children as liver iron, and serum ferritin do not reflect cardiac iron overload.

Hepatic Iron Deposition on Magnetic Resonance Imaging: Correlation with Inflammatory Activity

2002 ◽  
Vol 26 (6) ◽  
pp. 988-993 ◽  
Author(s):  
Myeong-Jin Kim ◽  
Donald G. Mitchell ◽  
Katsuyoshi Ito ◽  
Joo Hee Kim ◽  
Denise Pasqualin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Deposition ◽  
Inflammatory Activity ◽  
Hepatic Iron ◽  
Resonance Imaging

scholarly journals Smaller Amygdala Subnuclei Volume in Schizophrenia Patients with Violent Behaviors

2022 ◽  
Author(s):  
Hao Hu ◽  
Fengju Liu ◽  
Li Liu ◽  
Yi Mei ◽  
Bin Xie ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Central Nucleus ◽  
Violence Risk ◽  
Healthy Controls ◽  
Resonance Imaging ◽  
Basal Nucleus ◽  
Violent Behaviors ◽  
Weighted Magnetic Resonance Imaging

Abstract Objective To investigate the association between the volume of amygdala subnuclei and violent behaviors in patients with schizophrenia (SCZ). Methods In the present study, we recruited 40 SCZ patients with violent behaviors (VS), 26 SCZ patients without violent behaviors (NVS), and 28 matched healthy controls (HC) who completed T1-weighted magnetic resonance imaging. Both the total amygdala and amygdala subnuclei volumes were estimated with FreeSurfer. Results When comparing the whole SCZ patients with HC, SCZ patients had smaller volume of the left amygdala and the left basal nucleus. Further, the VS patients had smaller volume of the amygdala central nucleus as compared to the NVS group. Conclusions Our findings suggested that a smaller volume of the amygdala central nucleus might be relevant to violence risk in SCZ patients.

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