Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent

2005 ◽  
Vol 4 (4) ◽  
pp. 429-436 ◽  
Author(s):  
Y. Pu ◽  
W. B. Wang ◽  
G. C. Tang ◽  
F. Zeng ◽  
S. Achilefu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Contrast Agent ◽  
Near Infrared ◽  
Cancer Tissue ◽  
Polarization Imaging ◽  
Optical Window ◽  
Normal Tissues ◽  
Potential Marker ◽  
Prostate Cancer Tissue ◽  
Targeted Contrast Agent

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue “optical window”. The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

C-Ret Proto-Oncogene Expression in Human Prostate: An Immunohistochemical Evaluation

1997 ◽  
Vol 3 (S2) ◽  
pp. 21-22
Author(s):  
D.M. Dawson ◽  
E. G. Lawrence ◽  
G. MacLennan ◽  
T.G. Pretlow
Keyword(s):  
Prostate Cancer ◽  
Nervous System ◽  
Germ Line ◽  
Cancer Tissue ◽  
Transmembrane Receptors ◽  
Normal Tissues ◽  
Prostate Cancer Tissue ◽  
Neural Crest Origin ◽  
Altered Gene ◽  
Formalin Fixed

C-ret proto-oncogene encodes a protein in the tyrosine kinase (TK) family of transmembrane receptors for growth factors. C-ret expression has been identified in normal tissues and tumors of neural crest origin such as inherited MEN (multiple endocrine neoplasia) syndromes, particularly medullary thyroid cancers where there are confirmed germ-line mutations. Gene rearrangement has been observed in papillary thyroid carcinomas (PTC) and has been shown to have cytoplasmic localization of the altered gene product. C-ret proto-oncogene product is also necessary for the normal development of the peripheral nervous system, enteric nervous system and the kidney. A recent profile of the TK receptors in prostate cancer (PCA) identified c-ret protein in prostate cancer tissue and xenograft derived from human PCA. This study is the first to report the immunohistochemical (IH) evaluation of c-ret in human prostatic tissue.Thirty radical prostatectomy specimens for PCA were formalin-fixed, sectioned at 5mm and paraffin-embedded.

scholarly journals Increased expression of ARF GTPases in prostate cancer tissue

SpringerPlus ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Claire Morgan ◽  
Paul D Lewis ◽  
Lynda Hopkins ◽  
Stephanie Burnell ◽  
Howard Kynaston ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Tissue ◽  
Prostate Cancer Tissue ◽  
Arf Gtpases

scholarly journals Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics

2017 ◽  
Vol 56 (31) ◽  
pp. 8992-8997 ◽  
Author(s):  
David R. Spiciarich ◽  
Rosalie Nolley ◽  
Sophia L. Maund ◽  
Sean C. Purcell ◽  
Jason Herschel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tissue Slice ◽  
Human Prostate ◽  
Cancer Tissue ◽  
Human Prostate Cancer ◽  
Bioorthogonal Labeling ◽  
Prostate Cancer Tissue

404 DEVELOPMENT OF MULTIPARAMETRIC PROGNOSTIC MODELS USING LARGE PROSTATE CANCER TISSUE MICROARRAYS

2011 ◽  
Vol 10 (2) ◽  
pp. 141
Author(s):  
S. Minner ◽  
M.C. Tsourlakis ◽  
J. Müller ◽  
L. Burkhardt ◽  
P. Tennstedt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tissue Microarrays ◽  
Prognostic Models ◽  
Cancer Tissue ◽  
Prostate Cancer Tissue ◽  
Large Prostate

A Proposed New Technique in Prostate Cancer Tissue Bio-Banking: Our Experience with a New Protocol

2012 ◽  
Vol 18 (3) ◽  
pp. 663-668 ◽  
Author(s):  
Luca Carmignani ◽  
Stefano Picozzi ◽  
Stefano Casellato ◽  
Giorgio Bozzini ◽  
Carlo Marenghi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
New Technique ◽  
Cancer Tissue ◽  
Prostate Cancer Tissue
Sign in / Sign up

Export Citation Format

Share Document