scholarly journals Original Research: Polyphenols extracted from grape powder induce lipogenesis and glucose uptake during differentiation of murine preadipocytes

2016 ◽  
Vol 241 (16) ◽  
pp. 1776-1785 ◽  
Author(s):  
Sheida Torabi ◽  
Nancy M DiMarco
2018 ◽  
Vol 41 ◽  
Author(s):  
Alexa M. Tullett ◽  
Simine Vazire

AbstractWe contest the “building a wall” analogy of scientific progress. We argue that this analogy unfairly privileges original research (which is perceived as laying bricks and, therefore, constructive) over replication research (which is perceived as testing and removing bricks and, therefore, destructive). We propose an alternative analogy for scientific progress: solving a jigsaw puzzle.


2019 ◽  
Vol 476 (24) ◽  
pp. 3687-3704 ◽  
Author(s):  
Aphrodite T. Choumessi ◽  
Manuel Johanns ◽  
Claire Beaufay ◽  
Marie-France Herent ◽  
Vincent Stroobant ◽  
...  

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and differed only by the position of one double bond on one isoprenyl substituent. Treatment of MEFs with purified compound 1 or compound 2 led to rapid and robust AMPK activation at low micromolar concentrations and increased the intracellular AMP:ATP ratio. In oxygen consumption experiments on isolated rat liver mitochondria, compound 1 and compound 2 inhibited complex II of the electron transport chain and in freeze–thawed mitochondria succinate dehydrogenase was inhibited. In incubated rat skeletal muscles, both compounds activated AMPK and stimulated glucose uptake. Moreover, these effects were lost in muscles pre-incubated with AMPK inhibitor SBI-0206965, suggesting AMPK dependency. Incubation of mouse hepatocytes with compound 1 or compound 2 led to AMPK activation, but glucose production was decreased in hepatocytes from both wild-type and AMPKβ1−/− mice, suggesting that this effect was not AMPK-dependent. However, when administered intraperitoneally to high-fat diet-induced insulin-resistant mice, compound 1 and compound 2 had blood glucose-lowering effects. In addition, compound 1 and compound 2 reduced the viability of several human cancer cells in culture. The flavonoids we have identified could be a starting point for the development of new drugs to treat type 2 diabetes.


2008 ◽  
Vol 33 (8) ◽  
pp. 44-46 ◽  
Author(s):  
Jeffrey Kalish ◽  
Peter Burke ◽  
Jim Feldman ◽  
Suresh Agarwal ◽  
Andrew Glantz ◽  
...  

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
R Zapata-Bustos ◽  
AJ Alonso-Castro ◽  
J Romo-Yañez ◽  
LA Salazar-Olivo
Keyword(s):  

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
K Christensen ◽  
D Kotowska ◽  
L Olsen ◽  
S Bhattacharya ◽  
X Fretté ◽  
...  

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
HC Huang ◽  
CL Chao ◽  
SY Hwang ◽  
TC Chang ◽  
CH Chao ◽  
...  

2010 ◽  
Vol 49 (02) ◽  
pp. N10-N12 ◽  
Author(s):  
F. Cicone ◽  
M. Stalder ◽  
D. Geiger ◽  
A. Cairoli ◽  
A. Bischof Delaloye ◽  
...  

2018 ◽  
Vol 56 (08) ◽  
pp. e200-e201
Author(s):  
H Jodeleit ◽  
O Al-amodi ◽  
J Caesar ◽  
C Villarroel Aguilera ◽  
L Holdt ◽  
...  

1970 ◽  
Vol 1 (1) ◽  
pp. i-iv
Author(s):  
A K M A Islam

Journal of Scientific Research EDITORIAL Do we need a new journal? The answer lies in the fact that currently no international journal (online and print) with interdisciplinary character which specifically caters to the academic needs of the international community operates from Bangladesh. This journal aims to fill this lacuna and to be a bridge for the scientists from the east and the west. This is the first issue of the Journal of Scientific Research (JSR). The idea of launching a journal that hopes to publish quality scientific works was planted in early 2008 during a science faculty meeting at Rajshahi University. Now it is our pleasure to see the idea blossom into the first issue of first volume (1 January 2009) that contains scientific work not only of Asian regions but of much beyond that. The inaugural issue indicates the type of journal we hope to become. It is wide ranging and interdisciplinary. Our contributors include scholars at every stage of their academic career. As regards editorial policy and scope the Journal of Scientific Research is a peer-reviewed international journal originally intended for publication annually. But due to a satisfactory flow of manuscripts since the first announcements the publication frequency has now been increased to 3 online issues (one print volume) per year.The journal is a unifying force, going across the barriers between disciplines, addressing all related topics and materials. An international Editorial Board (along with an Advisory Board) comprising of renowned academics from various fields guides our editorial policy and direction. The journal is devoted to the publication of original research (research paper, review paper, short communication) covering the following fields:Section A:  Physical and Mathematical Sciences: Physics, Mathematics, Statistics, Geophysics, Computer, Environmental Science, Communications and Information Technology, Engineering and related branches.Section B:  Chemical and Biological Sciences: Chemistry, Biochemistry, Pharmacy, Biology, Genetics, Fisheries and related branches.The articles selected for the first issue have been reviewed by two discipline-specialists, and their recommendations have been appropriately incorporated. Submissions from the world research community are encouraged to fulfill our mission and aim for the journal to stand for the international scientific publishing standards.    It was clear during the planning and development of this first issue that the Asian region needs a forum through which research could be shared and acknowledged. I hope that this journal will soon be recognised by the wider research community as their forum for the dissemination of knowledge. We hope that the journal will not simply act as a place for publication of material, though obviously this is important, but should act as a catalyst for the advancement of science both within and outside the region.The journal is being published both online and in print. Online publishing, unique in nature, is faster and far less expensive than traditional hard copy publishing. Access of online journals is easier and better images, storage and multimedia are other advantages. I must thank the International Network for the availability of Scientific Publications (INASP) for helping us publish via BanglaJOL – and the help of Ms. Sioux Cumming in this regard is worthy of mention.The success of a journal depends on the quality of its Editorial Board and the reviewers. The effort that I have seen from them speaks well for the future of the new born journal.  Both the Editorial and Advisory Boards should deserve thanks for their indispensable advice and support during the planning phases of the journal. I should also thank the reviewers who contributed their valuable time to complete reviews within a reasonable time. I truly hope that the diversity contained in this first issue of the journal will be the hallmark of future issues. A K M A Islam email: [email protected]  website: www.banglajol.info/index.php/JSR           © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.vlil.1703    


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