Cerebral Blood Flow Volume in Posterior Circulation Ischemic Disorders

Objective: The aim of this study was to determine blood flow volume (BFV) in the normal state and its features in patients with acute posterior circulation ischemic strokes (PCIS) and vertebrobasilar insufficiency (VBI) using color duplex sonography (DS).Methods: The study included DS data from 96 patients with verified PCIS (66 men and 30 women, aged 64±13 years) and 29 adults with VBI (17 men and 12 women, aged 66±11 years). The control group consisted of 65 healthy male volunteers of different ages.Results: In asymptomatic healthy volunteers, there was a significant decrease in BFV in the internal carotid artery (ICA) with age (502 ml/min in young people, 465 ml/min in the older subgroup) with rS = −0.24 ( p = 0.05), and the aggregated BFV in the vertebral arteries (VAs) turned out to be almost constant (141–143 ml/min). In patients with VBI, the aggregated BFV in the VAs (144 ml/min) did not differ from that in healthy volunteers, but the BFV values in the ICAs were significantly lower (325 ml/min). In patients with PCIS, the aggregated BFV in the ICAs was also significantly lower (399 ml/min) than in the control group but did not significantly differ from that in patients with VBI. In patients with PCIS, there was a significant decrease in the aggregated BFV in the VAs (105 ml/min), which distinguished this group from other examined patients.Conclusions: A significant decrease the BFV in the VA was observed only in patients with PCIS and was associated with the presence of steno-occlusive diseases (SOD) more often in the left VA. Patients with VBI had the most pronounced decrease in BFV in the ICA.

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Age Dependence of Total Cerebral Blood Flow Volume from Childhood to Adulthood

Journal of Cerebral Blood Flow & Metabolism ◽

10.1097/00004647-199609000-00007 ◽

1996 ◽

Vol 16 (5) ◽

pp. 827-833 ◽

Cited By ~ 66

Author(s):

Martin Schöning ◽

Bernd Hartig

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Carotid Arteries ◽

Internal Carotid ◽

External Carotid ◽

Flow Volume ◽

Blood Flow Volume ◽

Vertebral Arteries ◽

The Common ◽

Carotid And Vertebral Arteries

In a prospective study of the natural development of total cerebral blood flow volume (CBFV), the common, external and internal carotid and vertebral arteries were examined in 94 healthy children and adolescents between 3 and 18 years of age (sex and age evenly distributed) using a 7.0-MHz transducer of a computed sonography system. Intravascular flow volumes were calculated with the product of angle-corrected time-averaged flow velocity and the cross-sectional area of the vessel. CBFV was determined as the sum of flow volumes in the internal carotid and vertebral arteries of both sides. CBFV increased significantly between 3 and 6.5 years of age (from 687 ± 85 to 896 ± 110 ml/min; age correlation, p ≤ 0.01) and declined thereafter ( p ≤ 0.001) to a constant level of ∼700 ml/min at 15 years of age. There was no difference in CBFV between sexes. The proportion of bilateral vertebral artery flow volume in total CBFV decreased significantly between the ages of 3 and 18 years ( p ≤ 0.001). As the flow volumes of the external carotid arteries increased markedly from childhood to adulthood, flow volumes of the common carotid arteries were not representative of CBFV. Intrasession test-retest correlation of CBFV was high ( r = 0.89, p ≤ 0.0001). Reference data for the childhood years presented here and previously described results from healthy adults allow us to outline the natural evolution of CBFV in humans. The reliability of the method has already been demonstrated. Thus, it may now be introduced into clinical application.

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