scholarly journals EXPRESS: COGNITIVE IMPACT OF CEREBRAL MICROBLEEDS IN PATIENTS WITH SYMPTOMATIC SMALL VESSEL DISEASE

2021 ◽  
pp. 174749302110128
Author(s):  
Stefania Nannoni ◽  
Laura Ohlmeier ◽  
Robin B Brown ◽  
Robin G Morris ◽  
Andrew D Mackinnon ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Dysfunction ◽  
Processing Speed ◽  
Rating Scale ◽  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vessel Disease ◽  
Independent Association

Background and aim Whether cerebral microbleeds (CMBs) cause cognitive impairment remains uncertain. We analysed whether CMBs are associated with cognitive dysfunction in patients with symptomatic cerebral small vessel disease (cSVD), and whether this association is independent of other cSVD neuroimaging markers. Methods We analysed consecutive patients with MRI-confirmed lacunar stroke included in DNA-Lacunar-2 multicentre study. CMBs were graded using the Brain Observer Microbleed Rating Scale (BOMBS). Neuropsychological assessment was performed using the Brief Memory and Executive Test (BMET). We analysed the association between CMBs, BMET and the following subdomains: executive function/processing speed (EF/PS) and orientation/memory (O/M). We also searched for an independent association between CMBs and vascular cognitive impairment (VCI), defined as BMET≤13. Results Out of 688 included patients, CMBs were detected in 192 (27.9%). After adjusting for WMH severity, lacune count and other confounders, both the presence and number of CMBs were significantly associated with impaired cognitive performance [β=-13.0; 95%CI= (-25.3;-0.6) and β=-13.1; 95%CI= (-19.8;-6.4), respectively]. On analysis of specific cognitive domains, associations were present for EF/PS [β=-5.8; 95%CI= (-9.3;-2.2) and β=-4.3; 95%CI= (-6.2;-2.4), respectively] but not for O/M [β=-0.4; 95%CI= (-4.0;3.2) and β=-2.1; 95%CI= (-4.0;0.1), respectively]. We also found an independent association between the presence and number of CMBs and VCI [adjusted OR=1.48; 95%CI= (1.01;2.18) and OR=1.43; 95%CI= (1.15;1.79), respectively). Conclusion In a large cohort of symptomatic cSVD patients, after controlling for other neuroimaging markers of cSVD severity, CMBs were associated with cognitive dysfunction. Executive function and processing speed were predominantly impaired. This might suggest a causal role of CMBs in determining VCI.

scholarly journals Cerebral small-vessel disease and decline in information processing speed, executive function and memory

Brain ◽  
2005 ◽  
Vol 128 (9) ◽  
pp. 2034-2041 ◽  
Author(s):  
Niels D. Prins ◽  
Ewoud J. van Dijk ◽  
Tom den Heijer ◽  
Sarah E. Vermeer ◽  
Jellemer Jolles ◽  
...  
Keyword(s):  
Information Processing ◽  
Executive Function ◽  
Processing Speed ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Information Processing Speed ◽  
Vessel Disease

Different cognitive profiles between mild cognitive impairment due to cerebral small vessel disease and mild cognitive impairment of Alzheimer’s disease origin

2009 ◽  
Vol 15 (6) ◽  
pp. 898-905 ◽  
Author(s):  
AIHONG ZHOU ◽  
JIANPING JIA
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Processing Speed ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Cognitive Domains ◽  
Vessel Disease

AbstractControversy surrounds the differences of the cognitive profile between mild cognitive impairment resulting from cerebral small vessel disease (MCI-SVD) and mild cognitive impairment associated with prodromal Alzheimer’s disease (MCI-AD). The aim of this study was to explore and compare the cognitive features of MCI-SVD and MCI-AD. MCI-SVD patients (n = 56), MCI-AD patients (n = 30), and normal control subjects (n = 80) were comprehensively evaluated with neuropsychological tests covering five cognitive domains. The performance was compared between groups. Tests that discriminated between MCI-SVD and MCI-AD were identified. Multiple cognitive domains were impaired in MCI-SVD group, while memory and executive function were mainly impaired in MCI-AD group. Compared with MCI-SVD, MCI-AD patients performed relatively worse on memory tasks, but better on processing speed measures. The AVLT Long Delay Free Recall, Digit Symbol Test, and Stroop Test Part A (performance time) in combination categorized 91.1% of MCI-SVD patients and 86.7% of MCI-AD patients correctly. Current study suggested a nonspecific neuropsychological profile for MCI-SVD and a more specific cognitive pattern in MCI-AD. MCI-AD patients demonstrated greater memory impairment with relatively preserved mental processing speed compared with MCI-SVD patients. Tests tapping these two domains might be potentially useful for differentiating MCI-SVD and MCI-AD patients. (JINS, 2009, 15, 898–905.)

Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment

2013 ◽  
Vol 73 (5) ◽  
pp. 584-593 ◽  
Author(s):  
Jae-Hyun Park ◽  
Sang Won Seo ◽  
Changsoo Kim ◽  
Geon Ha Kim ◽  
Hyun Jin Noh ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
In Vivo Imaging ◽  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vessel Disease

Cerebral microbleeds in patients with mild cognitive impairment and small vessel disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study

2016 ◽  
Vol 368 ◽  
pp. 195-202 ◽  
Author(s):  
Raffaella Valenti ◽  
Alessandra Del Bene ◽  
Anna Poggesi ◽  
Andrea Ginestroni ◽  
Emilia Salvadori ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vessel Disease

Abstract WP490: The Role of Blood Exosome Mirnas and its Correlation With Cognitive Domains in Cerebral Small Vessel Disease

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Xiang Cao ◽  
Yue Cheng ◽  
Fangyu Chen ◽  
Lili Huang ◽  
Dan Yang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Processing Speed ◽  
Verbal Fluency ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Log Transformation ◽  
Vessel Disease ◽  
Pearson's R ◽  
Pearson’S R

Introduction: Cerebral small vessel disease (CSVD) refers to a group of clinical syndromes involving cerebral arterioles, perforating arterioles, capillaries and venules, which is characterized by abnormal emotion, abnormal gait, urinary dysfunction, stroke, dementia and so on. It’s five to six times as much as stroke, and accounts for 45% of AD. Early forecast and early intervention can slow down the occurrence and development of cognitive impairment. Ethics number: 2016-134-01; Clinical Registration number: ChiCTR-OOC-17010562. Methods: 195 patients were enrolled in a case-control study and a cohort study. Exosomes were extracted by miRNeasy Serum/Plasma KIT (Qiagen). Transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and exosome reference particle size technique were used to identify exosomes, than, miRNA sequencing was performed and the results were analyzed and verified. Patients underwent neuropsychological measurement including the general cognitive examination and multiple cognitive domain assessments. Results: There were 5 differentially expressed exosome miRNAs between patients with cognitive impairment and the normal subjects, that was miRNA-330/miRNA-339/miRNA-432/miRNA-625/miRNA-6852 were associated with overall cognitive score ( P < 0.001). Among the miRNAs, Significant correlations were observed between miRNA-330 and executive function, as well as processing speed (Pearson’s r = 0.30 after log transformation, P = 0.002; Pearson’s r = 0.24 after log transformation, P = 0.039, respectively). miRNA-432 was significantly correlated to verbal fluency (Pearson’s r = -0.33 after log transformation, P < 0.001). Conclusions: Peripheral blood exosome miRNAs are markers for overall cognitive impairment and correlates with impairment in the domains executive function, verbal fluency and processing speed. It is of great significance for clinical early prevention and early treatment.

Abstract T P412: Cerebral Microbleeds and Cognition: The Framingham Heart Study

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Jose R Romero ◽  
Sarah R Preis ◽  
Alexa Beiser ◽  
Ashkan Shoamanesh ◽  
Rhoda Au ◽  
...  
Keyword(s):  
Risk Factors ◽  
Executive Function ◽  
Cognitive Performance ◽  
Small Vessel Disease ◽  
Vascular Risk Factors ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vascular Risk ◽  
Community Based ◽  
Vessel Disease

Objective: To study the association of cerebral microbleeds (CMB) on MRI and performance on a comprehensive neuropsychological test battery in a community based cohort free of stroke and dementia. Background: CMB represent hemorrhage-prone cerebral small vessel disease (SVD) and have been related to increased risk of dementia. In non-demented individuals, CMB may negatively affect cognition and the pattern of impaired cognitive performance may differ according to lesion topography. Methods: We evaluated 1744 Framingham Offspring Study participants (mean age 64.6 years, 54% women) attending a baseline examination (1998-2008), who had brain MRI allowing for CMB detection and underwent concurrent NP testing. Using multivariable linear regression we related CMB presence overall and stratified by brain location (lobar, deep or mixed) to performance on NP tests representing cognitive domains including memory, executive function, abstraction, language and visuospatial function. Results: CMB were observed in 7.7% of subjects (66% lobar, 20% deep, 14% mixed). After adjustment for sex, age, level of education and MRI markers of ischemic small vessel disease, presence of any CMB was associated with impaired performance on tests of abstraction (β -0.71, p=0.02) and language (β -0.13, p=0.04). The associations were attenuated after adjustment for vascular risk factors (hypertension, diabetes, smoking, prevalent cardiovascular disease). Lobar CMB showed similar marginal associations (p=0.05), also attenuated after adjustment for vascular risk factors. Mixed location CMB were associated with tests of executive function, an association that remained significant after adjustment for MRI markers of ischemic SVD and vascular risk factors (β-0.12, p= 0.02). CMB in only deep location did not show any significant association with NP test performance. Conclusions: CMB were associated with lower cognitive performance in a community-based sample of middle-aged adults. Our findings are limited given the cross sectional study design and small sample in subgroups of deep and mixed CMB, but concur with studies suggesting a negative impact of CMB on cognition, and expand prior studies by showing that the relations are independent of ischemic cerebral SVD.

Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study

2019 ◽  
Vol 32 (6) ◽  
pp. 336-343 ◽  
Author(s):  
Yan Liang ◽  
Yang-Kun Chen ◽  
Yong-Lin Liu ◽  
Vincent C. T. Mok ◽  
Gabor S. Ungvari ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Acute Ischemic Stroke ◽  
Cognitive Dysfunction ◽  
Small Vessel Disease ◽  
Estimating Equation ◽  
Word Recall ◽  
Small Vessel ◽  
Perivascular Spaces ◽  
Vessel Disease

Objective: This study investigated the association between small vessel disease (SVD) burden, a combination of multiple SVD markers and cognitive dysfunction after stroke. Methods: The study sample comprised 451 patients with first-ever acute ischemic stroke. Cognitive functions were assessed with the Mini-Mental State Examination (MMSE) at 3, 9, and 15 months after the index stroke. Cognitive impairment was defined as an MMSE score of ≤26. A total SVD score, indicating SVD burden, was constructed by summing the scores of the 4 SVD markers (white matter hyperintensities [WMHs], lacunes, cerebral microbleeds, and perivascular spaces) ascertained by magnetic resonance imaging (range: 0-4). The association between SVD burden and cognitive dysfunction was assessed with linear mixed models or generalized estimating equation models, as appropriate. Results: The majority of patients had mild-to-moderate stroke and at least one identifiable SVD marker. Cognitive impairment was found in about one-third of patients. After adjusting for confounding factors, the SVD burden was associated with MMSE scores (β = −0.37, P = .003) and cognitive impairment (odds ratio [OR] = 1.20, 95% confidence interval [CI] = 1.02-1.42). SVD burden was specifically associated with the performance of MMSE subscores including orientation to place and time, calculation, and word recall. Of the SVD markers, WMHs was the most robust predictor of decrease in MMSE scores (β = −0.25, P = .01) and cognitive impairment (OR = 1.14, 95% CI = 1.01-1.29). Conclusion: Cerebral SVD burden is associated with decreased MMSE scores, suggesting cognitive dysfunction during the first year after mild-to-moderate acute ischemic stroke.

scholarly journals Cerebral small vessel disease and cognitive impairment

2019 ◽  
Vol 07 (04) ◽  
pp. 184-195
Author(s):  
Lifang Meng ◽  
Jianhua Zhao ◽  
Junli Liu ◽  
Shaomin Li
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Dysfunction ◽  
Small Vessel Disease ◽  
Early Recognition ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Perivascular Spaces ◽  
Imaging Features ◽  
Vessel Disease ◽  
Vascular Origin

Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets. Imaging features vary; they are mainly composed of recent subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensities (WMHs) of presumed vascular origin, cerebral microbleeds, enlarged perivascular spaces, and global and regional brain atrophy. CSVD is a common cause of vascular cognitive dysfunction, and in its end stage, dementia often develops. CSVD has been a major research hotspot; however, its causes are poorly understood. Neuroimaging markers of CSVD can be used as the basis for etiological analysis. This review highlights the relevance of neuroimaging markers and cognitive impairment, providing a new direction for the early recognition, treatment, and prevention of cognitive dysfunction in small cerebral angiopathy.

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