The solubilities of benzoic acid and its nitro-derivatives, 3-nitro and 3,5-dinitrobenzoic acids

2021 ◽  
pp. 174751982110586
Author(s):  
Xiang Zhang ◽  
Jian Chen ◽  
Jinzhong Hu ◽  
Min Liu ◽  
Zhuoer Cai ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Ethyl Acetate ◽  
Temperature Range ◽  
Nitrobenzoic Acid ◽  
Nitro Derivatives

The solubilities of benzoic acid and its nitrated derivatives (3-nitrobenzoic acid and 3,5-dinitrobenzoic acid) in seven pure solvents—water, methanol, ethanol, acetonitrile, dichloromethane, toluene, and ethyl acetate—were determined experimentally over a temperature range from 273.15 K to 323.15 K under 101.3 kPa. The solubility of the above substances in these solvents increased with temperature. The solubility values of benzoic acid in these seven solvents follow the following order: ethanol > ethanol > acetonitrile > ethyl acetate > dichloromethane > toluene > water, while the solubility values of its nitrification derivatives in these seven solvents follow the following order: methanol > ethanol > ethyl acetate > acetonitrile > dichloromethane > toluene > water. The solubility of benzoic acid, 3-nitrobenzoic acid, and 3,5-dinitrobenzoic acid were significantly different in the same solvent. The solubilities obtained are very helpful in improving the recrystallization and yields of 3-nitrobenzoic acid and 3,5-dinitrobenzoic acid.

THE IONIZATION CONSTANTS OF p-NITROPHENYLACETIC AND PHENYLMALONIC ACIDS

1933 ◽  
Vol 8 (5) ◽  
pp. 447-449 ◽  
Author(s):  
Steward Basterfield ◽  
James W. Tomecko
Keyword(s):  
Benzoic Acid ◽  
Nitro Group ◽  
Malonic Acid ◽  
Phenylacetic Acid ◽  
Ionization Constants ◽  
Side Chain ◽  
Cooh Group ◽  
Conductivity Data ◽  
Nitrobenzoic Acid ◽  
Phenylmalonic Acid

The ionization constants of p-nitrophenylacetic and phenylmalonic acids have been determined from conductivity data. The value of K for p-nitrophenylacetic acid at 25 °C. is 1.04 × 10−4, about twice that of phenylacetic acid. The nitro group in the nucleus has not as powerful an effect on the ionization when the COOH group is in the side chain as it has when both nitro group and COOH are in the nucleus. K for p-nitrobenzoic acid is six times as great as K for benzoic acid. K for phenylmalonic acid is 2. 77 × 10−3 as compared with 1.6 × 10−3 for malonic acid.

Temperature Dependent Solubility of Benzoic Acid in Aqueous Phase and Aqueous Mixtures of Aliphatic Alcohols

2020 ◽  
Vol 234 (11-12) ◽  
pp. 1771-1787
Author(s):  
Sayyar Muhammad ◽  
Sofia Sanam ◽  
Hamayun Khan ◽  
Akhtar Muhammad ◽  
Sabiha Sultana
Keyword(s):  
Benzoic Acid ◽  
Aqueous Phase ◽  
Linear Trend ◽  
Pure Water ◽  
Binary Solvents ◽  
Aqueous Mixtures ◽  
Analytical Technique ◽  
Temperature Range ◽  
Acid Solubility ◽  
Ethanol In Water

AbstractThe benzoic acid solubility in aqueous phase and in various aqueous mixtures of methanol, ethanol and 2-propanol was determined at temperatures ranging from 303 to 333 K by an analytical technique. The results showed that the solubility of the acid in alcohols-water binary mixtures is high as compared to pure aqueous phase. The addition of alcohols to water favors the dissolution of benzoic acid which increases further with the increase in alcohols content of water within the investigated temperature range. The benzoic acid solubility in water alone and aqueous mixtures of the selected alcohols was in the order of; 2-propanol in water > ethanol in water > methanol in water > pure water. It is also observed that within the investigated temperature range, the acid solubility increases with rise in temperature in both the aqueous phase and alcohols-water binary solvents. The logarithm of the mole fraction of the acid’s solubility also showed a linear trend against the temperature. The experimental results obtained in the current study were compared with the reported literature for the studied acid and other organic acids in various solvents and showing a good agreement. The study will have implications in the processes involving separation, crystallization and pharmaceutical formulation in various industries.

scholarly journals Determination and Data Correlation of Solubility of Sofosbuvir Polymorphs in Ethyl Acetate + Toluene and Methyl tert-Butyl Ether Binary Solvents at the Temperature Range from 268.15 to 308.15 K

Crystals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 209
Author(s):  
Wei-Jie Ji ◽  
En-Fu Wang ◽  
Ming-Hui Qi
Keyword(s):  
Solid State ◽  
Ethyl Acetate ◽  
Light Exposure ◽  
Binary Solvents ◽  
Methyl Tert Butyl Ether ◽  
Butyl Ether ◽  
Strong Light ◽  
Temperature Range ◽  
Tert Butyl ◽  
Solid State Stability

A gravimetric method was used to experimentally determine the (solid + liquid) equilibrium of sofosbuvir of crystalline forms A and B in both ethyl acetate + toluene and methyl tert-butyl ether (MTBE) + toluene binary solvents systems at atmosphere pressure. Experiments were carried out at a temperature range of 268.15−308.15 K. Results show that the solubility of sofosbuvir increases with temperature, and the solubility of form B was higher than that of form A. The modified Apelblat model, the CNIBS/Redlich–Kister model, and the combined version of Jouyban–Acree model were employed to correlate the measured solubility data, respectively. Furthermore, an examination of the solid-state stability of the two polymorphs was conducted, finding that form A and form B exhibit good solid-state stability under high temperature, high humidity, and strong light exposure conditions.

Enhancement of the stability and temperature range of the mesophases in the binary mixtures of cholesteryl myristate and 4-n-decyloxy benzoic acid

2012 ◽  
Vol 112 (2) ◽  
pp. 767-775 ◽  
Author(s):  
Shraddha Chaturvedi ◽  
Navneet Chaturvedi ◽  
Rohit Verma ◽  
Abhay S. Pandey ◽  
S. N. Tiwari ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Binary Mixtures ◽  
Temperature Range ◽  
The Stability

Solubilities of Benzoic Acid,p-Methylbenzoic Acid,m-Methylbenzoic Acid,o-Methylbenzoic Acid,p-Hydroxybenzoic Acid, ando-Nitrobenzoic Acid in 1-Octanol

2008 ◽  
Vol 53 (6) ◽  
pp. 1278-1282 ◽  
Author(s):  
Jia Qingzhu ◽  
Ma Peisheng ◽  
Yi Shouzhi ◽  
Wang Qiang ◽  
Wang Chang ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Hydroxybenzoic Acid ◽  
Nitrobenzoic Acid

Ionization constants of benzoic and mononitrobenzoic acids in formamide

1972 ◽  
Vol 25 (5) ◽  
pp. 941 ◽  
Author(s):  
UN Dash ◽  
B Nayak
Keyword(s):  
Benzoic Acid ◽  
Ionization Constants ◽  
Weak Acids ◽  
General Behaviour ◽  
Nitrobenzoic Acid

The ionization constants of benzoic acid and of three mononitrobenzoic acids, at 25� in formamide, have been determined from the measurements of the electro-motive forces of the cells Pt,H2/HA(m1),KA(m2)KCl(m3)AgCl-Ag The values of the ionization constants for benzoic acid, o-nitrobenzoic acid, m-nitro-benzoio acid, and p-nitrobenzoic acid thus calculated from e.m.f. data are 4.37 x 10-7, 3.89 x 10-5, 3.98 x 10-6 and 1.32 x 10-6, respectively. These values are smaller than those in water, and are in agreement with a general behaviour exhibited by weak acids in solvents of this class.

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