A randomized controlled trial comparing ketorolac and triamcinolone injections in adults with trigger digits

2018 ◽  
Vol 43 (9) ◽  
pp. 936-941 ◽  
Author(s):  
Mabel Qi He Leow ◽  
Aik Siew Robyn Hay ◽  
Shu Li Ng ◽  
Muntasir Mannan Choudhury ◽  
Huihua Li ◽  
...  
Keyword(s):  
Complete Resolution ◽  
Controlled Trial ◽  
Flexion Deformity ◽  
Short Term ◽  
Level Of Evidence ◽  
Active Motion ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Total Active Motion ◽  
To Receive

We assessed the efficacy of ketorolac trometamol injections compared with triamcinolone acetonide injections in trigger digits. Patients with trigger digits were randomized to receive either ketorolac or triamcinolone. They were followed up at 3, 6, 12 and 24 weeks, and monitored for resolution of triggering, pain and total active motion. One hundred and twenty-one patients with single trigger digits were recruited (59 ketorolac, 62 triamcinolone). At 6 weeks, 54% of patients in the triamcinolone group had complete resolution of trigger, whereas no patients in the ketorolac group had resolution. At 12 weeks, 58% of patients in the triamcinolone group had complete resolution of trigger compared with 6.7% in the ketorolac group. At 24 weeks, both groups had comparable rates of resolution at 26% and 25%, respectively. Patients in the triamcinolone group had significantly better resolution of pain at 3, 6 and 12 weeks. But at 24 weeks, there was no significant difference in pain between both groups. Significantly less flexion deformity was reported at 3 weeks and 6 weeks in the triamcinolone group. In the short term, ketorolac was less effective in relieving symptoms of trigger digit than triamcinolone. Level of evidence: I

A multicentre, randomized, double-blind trial of the safety and efficacy of mannose-6-phosphate in patients having Zone II flexor tendon repairs

2014 ◽  
Vol 40 (7) ◽  
pp. 682-694 ◽  
Author(s):  
V. C. Lees ◽  
D. Warwick ◽  
P. Gillespie ◽  
A. Brown ◽  
M. Akhavani ◽  
...  
Keyword(s):  
Standard Care ◽  
Flexor Tendon ◽  
Controlled Trial ◽  
Teaching Hospitals ◽  
Level Of Evidence ◽  
Active Motion ◽  
Significant Difference ◽  
Total Active Motion ◽  
Zone Ii ◽  
Mannose 6 Phosphate

The safety, tolerability and preliminary efficacy of mannose 6-phosphate in enhancing the outcome in Zone II flexor tendon repair was studied in a multicentre parallel double-blinded randomized controlled trial. Eight UK teaching hospitals were involved in treating repaired flexor tendons with a single intraoperative intrathecal dose of 600 mM mannose 6-phosphate, with follow-up over 26 weeks. A total of 39 patients (mannose 6-phosphate, n = 20; standard care, n = 19) were randomized. Seven were excluded from the safety and tolerability analysis because of intraoperative findings and eight were excluded due to early dropout ( n = 4) or tendon rupture ( n = 4), leaving 24 (mannose 6-phosphate, n = 13; standard care, n = 11) for assessment of total active motion. The safety, tolerability and other side effects were comparable between the groups. There was no significant difference between the two groups in the total active motion at Week 26. We concluded that mannose 6-phosphate, although safe and tolerable, had no beneficial effect on finger range of motion after Zone II tendon division. Level of evidence 1b

scholarly journals EMDR Individual Protocol for Paraprofessional Use: A Randomized Controlled Trial With First Responders

2013 ◽  
Vol 7 (2) ◽  
pp. 55-64 ◽  
Author(s):  
Ignacio Jarero ◽  
Carolina Amaya ◽  
Martha Givaudan ◽  
Alaide Miranda
Keyword(s):  
Controlled Trial ◽  
First Responders ◽  
Global Improvement ◽  
Randomized Controlled ◽  
Posttraumatic Symptoms ◽  
Significant Difference ◽  
To Receive ◽  
Nonsignificant Decrease ◽  
Supportive Counseling

The eye movement desensitization and reprocessing (EMDR) individual protocol for paraprofessional use in acute trauma situations (EMDR-PROPARA) is part of a project developed at the initiative of Dr. Francine Shapiro. This randomized clinical trial examined the effectiveness of the protocol administered by experienced EMDR therapists. There were 39 traumatized first responders on active duty randomly assigned to receive two 90-min sessions of either EMDR-PROPARA or of supportive counseling. Participants in the EMDR-PROPARA group showed benefits immediately after treatment, with their scores on the Short PTSD Rating Interview (SPRINT) showing further decreases at 3-month follow-up. In comparison, supportive counseling participants experienced a nonsignificant decrease after treatment and an increase in the SPRINT scores at the second follow-up. The significant difference between the two treatments provides preliminary support for EMDR-PROPARA’s effectiveness in reducing severity of posttraumatic symptoms and subjective global improvement. More controlled research is recommended to evaluate further the efficacy of this intervention.

Effect of Oral Prednisolone after Collagenase Injection for Dupuytren’s Contracture: A Randomized, Controlled Trial with a 1-Year Follow-Up

2020 ◽  
Author(s):  
Yoshihiro Abe
Keyword(s):  
Controlled Trial ◽  
Oral Prednisolone ◽  
Metacarpophalangeal Joint ◽  
Control Group ◽  
Dupuytren’S Contracture ◽  
Active Motion ◽  
Dupuytren's Contracture ◽  
Significant Difference ◽  
Total Active Motion

Abstract Introduction This study verified the effectiveness of oral prednisolone after collagenase clostridium histolyticum (CCH) (10 mg/day for 2 weeks) for Dupuytren’s contracture with a 1-year follow-up. Materials and Methods This study included 31 patients with a contracture of the metacarpophalangeal joint of ≥ 30 degrees. A total of 16 patients were allocated randomly to treatment with prednisolone and 15 patients were treated without prednisolone (control group). Results At day 7, mean total active motion (TAM) was 235 degrees in the prednisolone group and 228 degrees in the control group. Mean Visual Analog Scale was 3.3 in the prednisolone group and 4.6 in the control group. There was significant difference between two groups. At day 30, mean TAM was 241 degrees in the prednisolone group and 233 degrees in the control group. There were significant difference between two groups The mean QuickDASH score was significantly higher in the control group (5.8 vs. 3.4). Recurrence was observed in 2/16 patients (13%) in the prednisolone group and 5/15 patients (33%) in the control group; there was no significant difference. Conclusion The administration of prednisolone decreased the likelihood of adverse effects, and also improved finger flexion range of motion and reduced pain after CCH.

Efficiency of Hyaloglide® in the prevention of the recurrence of adhesions after tenolysis of flexor tendons in zone II: a randomized, controlled, multicentre clinical trial

2009 ◽  
Vol 35 (2) ◽  
pp. 130-138 ◽  
Author(s):  
M. Riccio ◽  
B. Battiston ◽  
G. Pajardi ◽  
M. Corradi ◽  
U. Passaretti ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Treated Group ◽  
Control Group ◽  
Time Intervals ◽  
Active Motion ◽  
Randomized Controlled ◽  
Total Active Motion ◽  
Group A ◽  
Quick Dash ◽  
Dash Questionnaire

Hyaloglide® is a hyaluronan-based gel based on a novel auto-crosslinked technology designed to reduce postsurgical adhesions. Its efficacy was assessed in a multicentred randomized controlled trial comparing the results of flexor tenolysis in zone 2 following failed flexor tendon repairs. In the control group a standard release was performed. In the treated group, Hyaloglide® was applied into the flexor sheath and around the site of tenolysis. Forty-five patients, 19 controls and 26 treated with Hyaloglide®, were enrolled in 13 centres. All the patients were evaluated at 30, 60, 90 and 180 days after surgery by testing Total Active Motion, Quick-DASH questionnaire and number of working days lost after surgery. Patients in the Hyaloglide® group had a statistically better recovery of finger motion at all time intervals and returned earlier to work and daily activities. The use of Hyaloglide® did not appear to increase the complication rate.

scholarly journals Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Shiva Ganjali ◽  
Amirhossein Sahebkar ◽  
Elahe Mahdipour ◽  
Khadijeh Jamialahmadi ◽  
Sepideh Torabi ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Serum Levels ◽  
Immunomodulatory Effects ◽  
Serum Samples ◽  
Randomized Controlled ◽  
Array Technology ◽  
Significant Difference ◽  
Daily Dose ◽  
Present Trial ◽  
To Receive

Background. Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy of curcumin, a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects, on the serum levels of a panel of cytokines and mediators in obese individuals.Methods. Thirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks. Following a 2-week wash-out period, each group was assigned to the alternate treatment regimen for another 4 weeks. Serum samples were collected at the start and end of each study period. Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNFαwere measured using a multiplex Biochip Array Technology based method.Results. Mean serum IL-1β(P=0.042), IL-4 (P=0.008), and VEGF (P=0.01) were found to be significantly reduced by curcumin therapy. In contrast, no significant difference was observed in the concentrations of IL-2, IL-6, IL-8, IL-10, IFNγ, EGF, and MCP-1.Conclusions. The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.

scholarly journals Comparative outcomes of foot cast and short leg cast in pseudo-Jones avulsion fracture: a single blinded randomized controlled trial

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Peerapong Piyapittayanun ◽  
Kanakij Mutthakalin ◽  
Alisara Arirachakaran ◽  
Jatupon Kongtharvonskul
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Randomized Controlled ◽  
Metatarsal Bones ◽  
Significant Difference ◽  
Metatarsal Fractures ◽  
The Mean ◽  
Foot Fractures ◽  
To Receive

Abstract Background Fractures of the metatarsal bones account for 35% of all foot fractures. Conservative management of fractures proximal to the metaphyseal-diaphyseal junction of the fifth metatarsal bone (pseudo-Jones) is by protected weight bearing. The methods of protected weight bearing include short-leg casting and splinting (boot cast, Jones’s bandage and elastic bandage). However, currently there is no consensus as to which method is the most suitable. Method We have conducted a randomized controlled trial to compare outcomes of foot casting (FC) and short leg casting (SLC) to assess pain, function and complication outcomes for the treatment of pseudo-jones metatarsal fractures. This single-center, single blind,randomized controlled trial was conducted between 1 June 2016–1 July 2018 at Police General Hospital, Bangkok, Thailand. Result A total of 72 pseudo-jones metatarsal fracture participants were randomly allocated to treatment by foot cast or short leg cast. The primary outcomes were pain VAS, AOFAS and complications measured at 2, 4, 6 and 8 weeks after receiving the treatment. Seventy-two patients (36 paticipants per group) were enrolled to receive either FC or SLC. The mean VAS measured at baseline, 2 weeks, 4 weeks, 6 weeks and 8 weeks were 7.36, 1.97, 0.58, 0.17 and 0.08 respectively in the FC group; and 6.09, 2.91, 1.23, 0.37 and 0.11 respectively in the SLC group. The mean AOFAS at baseline, 2, 4, 6 and 8 weeks were 33.60, 68.22, 82.72, 91.75 and 98.11 respectively in the FC group; and 32.60, 60.20, 70.20, 92.24 and 99.13 in the SLC group. The estimated mean difference of pain VAS and AOFAS at 2 weeks and 4 weeks were − 0.94 (95% CI: − 1.53, − 0.34), − 0.65 (95%CI: − 1.24, − 0.05), 8.02 (95%CI: 3.74, 12.10) and 12.52 (95%CI: 8.27, 16.78), which were statistically significantly better in the FC groups when compared to the SLC groups. However, there were no statistically significant difference between the two groups at 6 and 8 weeks. Conclusion This study demonstrated that the application of foot casting can improve pain VAS and AOFAS function at 2 and 4 weeks in the treatment of pseudo-jones metatarsal fractures when compared to short leg casting. However, at 6 and 8 weeks, there were no statistically significantly different between the two groups.

A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL OF CONTROLLED PASSIVE MOBILIZATION VS. PLACE AND ACTIVE HOLD EXERCISES AFTER ZONE 2 FLEXOR TENDON REPAIR

Hand Surgery ◽  
2014 ◽  
Vol 19 (01) ◽  
pp. 53-59 ◽  
Author(s):  
Maryam Farzad ◽  
Fereydoun Layeghi ◽  
Ali Asgari ◽  
David C. Ring ◽  
Masoud Karimlou ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Flexor Tendon ◽  
Controlled Trial ◽  
Tendon Repair ◽  
Flexor Tendon Repair ◽  
Active Motion ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Total Active Motion ◽  
Passive Mobilization

Purpose: The rehabilitation program after flexor tendon repair of zone II laceration varies. We designed a Prospective Randomized Controlled Trial of controlled passive mobilization (modified Kleinert) vs. Place and active hold exercises after zone 2-flexor tendon repair by two-strand suture (Modified kessler). Methods: Sixty-four fingers in 54 patients with zone 2 flexor tendon modified Kessler repairs were enrolled in a prospective randomized controlled trial comparing place and active hold exercises to controlled passive mobilization (modified Kleinert). The primary outcome measure was total active motion eight weeks after repair as measured by an independent and blinded therapist. Results: Patients treated with place and active hold exercises had significantly greater total active motion (146) eight weeks after surgery than patients treated with controlled passive mobilization (114) (modified Klinert). There were no ruptures in either group. Conclusions: Place and hold achieves greater motion than controlled passive mobilization after a two-strand repair for zone 2 flexor tendon repairs.

scholarly journals A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xie-He Kong ◽  
Yue Zhao ◽  
Zhi Chen ◽  
Li Zeng ◽  
Rong Han ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Controlled Trial ◽  
Repeated Measurements ◽  
Eye Drops ◽  
Myopia Progression ◽  
Randomized Controlled ◽  
Significant Difference ◽  
To Receive ◽  
Acupoint Stimulation ◽  
Myopia Control

Background. Use of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to compare the effect of 0.01% A combined with AAS and 0.01% A alone on myopia progression and choroidal thickness in children. Methods. A total of 104 children were stratified by age and randomly assigned at 1 : 1 to receive 0.01% A or 0.01% A + AAS treatment for 6 months. Repeated measurements of cycloplegic spherical equivalent (SE) autorefraction, axial length (AL), and choroidal thickness were performed at baseline, 1 month, 3 months, and 6 months. Results. The adjusted mean SE change over the 6 months was −0.38 ± 0.04 D in the 0.01% A group (n = 50) and −0.25 ± 0.04 D in the 0.01% A + AAS group (n = 50), demonstrating a significant between-group difference ( P  = 0.02). There was no statistically significant difference in the change of AL and choroidal thickness between the two groups (both P  > 0.05). Conclusions. Adjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316.

scholarly journals The Effect of Virgin Coconut Oil (VCO) on Physiological Halitosis. A Randomized Controlled Pilot Trial

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Zurainie Abllah ◽  
Siti Khadijah Shahnon ◽  
Nurain Najihah Nuawi ◽  
Yunita Dewi Ardini
Keyword(s):  
Controlled Trial ◽  
Pilot Trial ◽  
Coconut Oil ◽  
Short Term ◽  
Randomized Controlled ◽  
Oral Malodour ◽  
Significant Difference ◽  
Group B ◽  
Post Assessment

Introduction: VCO oil pulling therapy has been used as a remedy for oral malodour in traditional Indian folk. Main objective for this research is to study on the effect of VCO oil pulling on physiological halitosis among IIUM Kuantan Campus students. The specific objectives are to evaluate the effect of VCO oil pulling on physiological halitosis and to compare the efficacy of VCO with conventional mouthwash in reducing physiological halitosis. Materials and method: 20 convenient samples were selected based on inclusion and exclusion criteria and divided into two groups, mouthwash and VCO based on single blind randomized controlled trial. Subjects required swishing oil pulling (group A) or rinsing with mouthwash (group B). Breathing analysis was recorded during pre-assessment, post assessment (on day 1short term and day 14-long term) using organoleptic 1, organoleptic 2 (selfassessment) and Tanita device. The results were analysed using paired t-test in SPSS version 22. IREC approval: 2018-061. Result: There were significant difference between pre and post assessment of mouthwash in short term (p<0.001) and long term (p=0.002) period of usage and between group VCO pre and post assessment in short term (p=0.001). However, there was no significant (p<0.05) between group of VCO and mouthwash. Conclusion: VCO has potential to reduce physiological halitosis in immediate observation after the oil pulling procedure. VCO oil pulling and gargling with commercial mouthwash had no significant difference in reducing physiological halitosis.

scholarly journals Recovery of rock climbing performance after surgical reconstruction of finger pulleys

2016 ◽  
Vol 41 (4) ◽  
pp. 406-412 ◽  
Author(s):  
M. Bouyer ◽  
A. Forli ◽  
A. Semere ◽  
B. J. Chedal Bornu ◽  
D. Corcella ◽  
...  
Keyword(s):  
Sport Performance ◽  
Rock Climbing ◽  
Surgical Reconstruction ◽  
Pinch Strength ◽  
Level Of Evidence ◽  
Active Motion ◽  
Significant Difference ◽  
Total Active Motion ◽  
The Mean ◽  
High Level

This study evaluated recovery of sport performance and correction of bowstringing after surgical reconstruction of closed finger pulley rupture in high-level rock climbers. A total of 38 patients treated with an extensor retinaculum graft were assessed. The mean follow-up time was 85 months, and 30 patients returned to their previous climbing level. The mean total active motion score was 96% of the opposite side. All patients had an excellent Buck-Gramcko score. There was no significant difference in grip strength and tip pinch strength in the crimp position between the injured side and the opposite side. A total of 31 patients were examined with ultrasonography. In 18, flexor bowstringing effects had returned to near-normal values. There was an association between rock climbing level recovery and the flexor bowstringing correction (odds ratio, 6.9; 95% confidence interval, 1.1–42.8). If flexor bowstringing was corrected, patients were more likely to regain their preinjury sport performance. The ultrasonography measurement was a useful tool for predicting functional recovery. Level of evidence: 4

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